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  1. 3 Aug 2014
    (Oral antiviral treatment to prevent genital herpes outbreaks in immunocompetent and nonpregnant patients) New
    Review question Are oral antiviral drugs (acyclovir, famciclovir, and valacyclovir) effective compared with placebo? And is one of these three drugs superior to the others in suppressing genital herpes outbreaks in patients experiencing four or more recurrences per year? Effectiveness in this review was evaluated by determining the risk of experiencing ...
  2. 15 Sep 2014
    A review of the ways in which healthcare professionals can be helped to involve their patients in the healthcare decision making process Updated
    When there are several treatments possible, healthcare professionals can involve patients in the process of making decisions about their care so that the patients can choose care that meets their needs and reflects what is important to them. We call this 'shared decision making'. Although the results are better when patients are involved, healthcare ...
  3. 21 Aug 2014
    Advanced training in trauma life support for ambulance crews Updated
    Injury is one of the top ten causes of death and disability worldwide. It results in an early loss of life for many young people and ongoing high medical care costs among survivors. Advanced life support (ALS) training for ambulance crews with emphasis on trauma is believed to have contributed to a reduction in the number of deaths from injury in predominantly ...
  4. 22 Aug 2014
    Advanced training in trauma life support for hospital staff Updated
    Training in 'advanced trauma life support' (ATLS) is increasingly used in both rich and poor countries. ATLS is intended to improve the way in which care is given to injured people, thereby reducing death and disability. Some research has been done that suggests ATLS programmes improve the knowledge of staff who have been trained, but there have been ...
  5. 12 Sep 2014
    Agitation in children after sevoflurane anaesthesia New
    Review question We reviewed the evidence looking at how often children wake up agitated after a sevoflurane general anaesthetic compared with other general anaesthetics. We also reviewed evidence looking at the effects of other treatments (e.g. a medication given during the anaesthetic, the presence of a parent when a child wakes up) on how often ...
  6. 10 Sep 2014
    Anticonvulsant therapy for status epilepticus Updated
    Some patients develop abnormal excessive electrical activity of brain nerve cells. This is called seizure activity and may involve a small area of the brain or the whole brain, resulting in sudden dysfunction of the structures involved, such as shaking of the limbs. The seizure activity often results in jerky movements (convulsions) and usually lasts ...
  7. 11 Sep 2014
    Antidepressants for postnatal depression Updated
    Why is this review important? Postnatal depression is a common disorder that can have short- and long-term adverse effects on the mother, the new infant and the family as a whole. Antidepressants are commonly used as the first treatment option for adults with moderate to severe depression, but there is little evidence on whether antidepressants are ...
  8. 2 Aug 2014
    Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis (ICVT) Updated
    Review question We reviewed the evidence around the use of antiepileptic medication to prevent seizures after intracranial venous thrombosis. Background Intracranial venous thrombosis is caused by blood clots in a vein or venous sinus in the brain. This can result in seizure activity. It remains unclear which people with intracranial venous thrombosis ...
  9. 5 Sep 2014
    Antiepileptic drugs versus no treatment or placebo for children with benign epilepsy with centro temporal spikes New
    Benign epilepsy with centro temporal spikes is one of the most common childhood seizure disorders . Treatment for this disorder has been controversial as almost all individuals achieve seizure freedom by adolescence. However, this seizure disorder may not be as benign as the name suggests as children may have specific cognitive impairment. Treatment ...
  10. 17 Sep 2014
    Antigen-specific active immunotherapy for ovarian cancer Updated
    Background Ovarian cancer is the leading cause of death from gynaecological cancers. Standard therapy consists of surgery and chemotherapy. Responses to chemotherapy are generally good, however, the majority of women will relapse, for which no curative treatment is available. The presence of certain immune cells in tumours is associated with longer ...

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