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  1. 23 Jul 2014
    11C-PIB-PET scan for early prediction of developing Alzheimer’s disease or other dementia in people with mild cognitive impairment (MCI) New
    The numbers of people with dementia and other cognitive problems are increasing globally. A diagnosis of the pre-dementia phase of disease is recommended but there is no agreement on the best approach. A range of tests have been developed which healthcare professionals can use to assess people with poor memory or cognitive impairment. Based on the published ...
  2. 26 Jul 2014
    A comparison of the effectiveness and safety of the two most common therapies for people with multiple sclerosis (MS) New
    Background At present no clear evidence is available on the equivalence of therapeutic agents used in people with MS. This study is important because it is the first report evaluating whether two treatments, interferons (IFNs)-beta and glatiramer acetate (GA), have the same effect on the disease course. Study characteristics We searched medical databases ...
  3. 30 Jun 2014
    A single dose of primaquine added to malaria treatment to prevent malaria transmission Updated
    We conducted a review of the effects of adding a single dose (or short course) of primaquine to malaria treatment with the aim of reducing the transmission of malaria. We included 17 randomized controlled trials and one quasi-randomized controlled trial. What is primaquine and how might it reduce transmission Primaquine is an antimalarial drug which ...
  4. 3 Jul 2014
    A structured interview for assessing change in memory and other thinking skills (the IQCODE) for assessment of possible dementia New
    Numbers of people with dementia and other memory and thinking problems are increasing globally. Early diagnosis of dementia is recommended but there is no agreement on the best approach or how non-memory specialists should assess patients. A potential strategy is to interview friends or family of the subject to assess for change in memory or other thinking ...
  5. 23 Jun 2014
    Acupuncture for sudden-onset ankle sprains in adults New
    An acute ankle sprain is a sudden-onset injury of the ankle ligaments (tough strands of tissue that connect and stabilise the bones at the ankle). It is one of the most common injuries in the general population as well as in athletes. Acupuncture is frequently used for treating ankle sprains in eastern Asian countries. This review aimed to assess the ...
  6. 17 Jul 2014
    Air versus saline in the loss of resistance technique for identification of the epidural space New
    Review question Which technique, air or saline, is more efficacious and safe in reducing complications during the loss of resistance technique (sudden loss of pressure on the plunger of the syringe, making the plunger slide smoothly) for identification of the epidural space, and what guidance can be provided to clinicians in their clinical practice? ...
  7. 4 Jun 2014
    Aloe vera for prevention and treatment of infusion phlebitis New
    Infusion phlebitis is acute inflammation of a vein in the presence of intravenous therapy. In modern medical practice, more than 80% of inpatients will receive intravenous therapy during their admission, and about 20% to 70% of them may develop infusion phlebitis. Therefore infusion phlebitis is the most common complication of intravenous therapy. However, ...
  8. 10 Jun 2014
    Alpha blocker treatment for men to increase chances to have urinary catheter successfully removed Updated
    Background on the condition Acute urinary retention in men is a medical emergency characterised by the sudden and often painful inability to pass urine. There are many known causes including prostate obstruction (because of enlargement of the prostate or cancer), urethral strictures (a narrowing of the urethra due to scar tissue), urine infection, ...
  9. 8 Jul 2014
    Alternating current cranial electrotherapy stimulation in the treatment of depression New
    Review question We reviewed the evidence on the use of cranial electrical stimulation (CES) in people with acute depression. More specifically, we were interested in examining the evidence from high quality clinical trials in which patients with acute depression were randomly assigned to treatment with either active CES or sham (simulated) CES, We ...
  10. 17 Jun 2014
    Aminoadamantanes versus other antiviral drugs for chronic hepatitis C New
    Background Hepatitis C virus is mainly transmitted by contact to infected blood. Chronic hepatitis C infection affects around 3% of the world population and progresses slowly. Most patients present without symptoms, or with symptoms like fatigue or liver-related morbidity. Frequently, the disease is discovered by coincidence because of abnormal laboratory ...

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