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  1. 3 Aug 2014
    (Oral antiviral treatment to prevent genital herpes outbreaks in immunocompetent and nonpregnant patients) New
    Review question Are oral antiviral drugs (acyclovir, famciclovir, and valacyclovir) effective compared with placebo? And is one of these three drugs superior to the others in suppressing genital herpes outbreaks in patients experiencing four or more recurrences per year? Effectiveness in this review was evaluated by determining the risk of experiencing ...
  2. 23 Jul 2014
    11C-PIB-PET scan for early prediction of developing Alzheimer’s disease or other dementia in people with mild cognitive impairment (MCI) New
    The numbers of people with dementia and other cognitive problems are increasing globally. A diagnosis of the pre-dementia phase of disease is recommended but there is no agreement on the best approach. A range of tests have been developed which healthcare professionals can use to assess people with poor memory or cognitive impairment. Based on the published ...
  3. 26 Jul 2014
    A comparison of the effectiveness and safety of the two most common therapies for people with multiple sclerosis (MS) New
    Background At present no clear evidence is available on the equivalence of therapeutic agents used in people with MS. This study is important because it is the first report evaluating whether two treatments, interferons (IFNs)-beta and glatiramer acetate (GA), have the same effect on the disease course. Study characteristics We searched medical databases ...
  4. 3 Jul 2014
    A structured interview for assessing change in memory and other thinking skills (the IQCODE) for assessment of possible dementia New
    Numbers of people with dementia and other memory and thinking problems are increasing globally. Early diagnosis of dementia is recommended but there is no agreement on the best approach or how non-memory specialists should assess patients. A potential strategy is to interview friends or family of the subject to assess for change in memory or other thinking ...
  5. 21 Aug 2014
    Advanced training in trauma life support for ambulance crews Updated
    Injury is one of the top ten causes of death and disability worldwide. It results in an early loss of life for many young people and ongoing high medical care costs among survivors. Advanced life support (ALS) training for ambulance crews with emphasis on trauma is believed to have contributed to a reduction in the number of deaths from injury in predominantly ...
  6. 22 Aug 2014
    Advanced training in trauma life support for hospital staff Updated
    Training in 'advanced trauma life support' (ATLS) is increasingly used in both rich and poor countries. ATLS is intended to improve the way in which care is given to injured people, thereby reducing death and disability. Some research has been done that suggests ATLS programmes improve the knowledge of staff who have been trained, but there have been ...
  7. 17 Jul 2014
    Air versus saline in the loss of resistance technique for identification of the epidural space New
    Review question Which technique, air or saline, is more efficacious and safe in reducing complications during the loss of resistance technique (sudden loss of pressure on the plunger of the syringe, making the plunger slide smoothly) for identification of the epidural space, and what guidance can be provided to clinicians in their clinical practice? ...
  8. 8 Jul 2014
    Alternating current cranial electrotherapy stimulation in the treatment of depression New
    Review question We reviewed the evidence on the use of cranial electrical stimulation (CES) in people with acute depression. More specifically, we were interested in examining the evidence from high quality clinical trials in which patients with acute depression were randomly assigned to treatment with either active CES or sham (simulated) CES, We ...
  9. 22 Aug 2014
    Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension New
    Background Hypertension, or persistent high blood pressure above 140/90 mmHg, is a prevalent risk factor that is associated with strokes and heart disease. To prevent these events, angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are used widely to treat hypertension, with ARBs often substituted for ACE inhibitors ...
  10. 2 Aug 2014
    Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis (ICVT) Updated
    Review question We reviewed the evidence around the use of antiepileptic medication to prevent seizures after intracranial venous thrombosis. Background Intracranial venous thrombosis is caused by blood clots in a vein or venous sinus in the brain. This can result in seizure activity. It remains unclear which people with intracranial venous thrombosis ...

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