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  1. 3 Aug 2014
    (Oral antiviral treatment to prevent genital herpes outbreaks in immunocompetent and nonpregnant patients) New
    Review question Are oral antiviral drugs (acyclovir, famciclovir, and valacyclovir) effective compared with placebo? And is one of these three drugs superior to the others in suppressing genital herpes outbreaks in patients experiencing four or more recurrences per year? Effectiveness in this review was evaluated by determining the risk of experiencing ...
  2. 21 Aug 2014
    Advanced training in trauma life support for ambulance crews Updated
    Injury is one of the top ten causes of death and disability worldwide. It results in an early loss of life for many young people and ongoing high medical care costs among survivors. Advanced life support (ALS) training for ambulance crews with emphasis on trauma is believed to have contributed to a reduction in the number of deaths from injury in predominantly ...
  3. 22 Aug 2014
    Advanced training in trauma life support for hospital staff Updated
    Training in 'advanced trauma life support' (ATLS) is increasingly used in both rich and poor countries. ATLS is intended to improve the way in which care is given to injured people, thereby reducing death and disability. Some research has been done that suggests ATLS programmes improve the knowledge of staff who have been trained, but there have been ...
  4. 29 Aug 2014
    Anti-vascular endothelial growth factor for neovascular age-related macular degeneration Podcast Updated
    Background Age-related macular degeneration (AMD) is a common cause of severe vision loss in people 55 years and older. Neovascular AMD, which involves abnormal growth of blood vessels in the back of the eye, accounts for most AMD-related severe vision loss. Injections into the eye of medications, such as pegaptanib, ranibizumab, and bevacizumab, that ...
  5. 2 Aug 2014
    Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis (ICVT) Updated
    Review question We reviewed the evidence around the use of antiepileptic medication to prevent seizures after intracranial venous thrombosis. Background Intracranial venous thrombosis is caused by blood clots in a vein or venous sinus in the brain. This can result in seizure activity. It remains unclear which people with intracranial venous thrombosis ...
  6. 21 Aug 2014
    Antioxidants to reduce pain in chronic pancreatitis New
    Chronic pancreatitis is a persistent inflammation of the pancreas that in the long run can cause irreparable damage. The major causes of chronic pancreatitis are genetics, alcohol toxicity and other conditions that might damage or obstruct the pancreas. This inflammation can cause pain that often is severe and leaves patients socially isolated and unable ...
  7. 3 Aug 2014
    Aspirin as an additional treatment for giant cell arteritis New
    Background Giant cell arteritis (GCA) is a condition where inflammation destroys the wall of arterial blood vessels usually seen in the head. GCA affects people over the age of 50 years and is more common as people get older. Early on people feel tired and unwell; they have loss of appetite and can lose weight. Most people then develop a new headache, ...
  8. 1 Aug 2014
    Azathioprine and 6-mercaptopurine for the maintenance of surgically-induced remission in Crohn’s disease New
    Prevention of clinical relapse (resumption of symptoms of active disease) and endoscopic relapse (signs of mucosal inflammation upon examination with an endoscope) are key objectives in the management of Crohn’s disease. There is no treatment currently available that completely prevents relapse and is without significant side-effects. The purpose of ...
  9. 20 Aug 2014
    Budesonide for maintenance of remission in Crohn's disease Updated
    Budesonide is a corticosteroid drug which is rapidly broken down by the liver, reducing corticosteroid-related side effects (e.g., moon face). Research showing that budesonide is effective in treating active Crohn's disease has led to clinical trials examining the effect of budesonide on reducing disease recurrence in non-active Crohn's disease. This ...
  10. 11 Aug 2014
    Closure versus non-closure of the peritoneum at caesarean section: long- and short-term outcome Updated
    Not stitching the peritoneum after caesarean section takes less theatre time and therefore has less cost, but information on possible long-term disadvantages are limited. There are many ways of performing a caesarean section and the techniques used depend on a number factors including the clinical situation and the preference of the operator. The peritoneum ...

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