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  1. 18 Sep 2014
    Certolizumab pegol for treating adults with rheumatoid arthritis Updated
    We conducted an updated review of the effect of certolizumab pegol for adults with RA. We searched all relevant studies until June 2014 and found 11 studies with 4324 people. In people with rheumatoid arthritis: - certolizumab pegol probably improved the American College of Rheumatology ACR50 (pain, function and other symptoms of RA), health-related ...
  2. 18 Sep 2014
    Ritalin for adult attention deficit hyperactivity disorder (ADHD) New
    Background Symptoms of attention deficit hyperactivity disorder (ADHD), diagnosed mainly in children, often persist into adulthood, afflicting 1% to 6% of the general population. Adults with ADHD have higher rates of other psychiatric problems and functional difficulties in a number of key areas such as academic achievement, interpersonal relationships, ...
  3. 17 Sep 2014
    Acellular vaccines for preventing whooping cough (pertussis) in children Updated
    Review question We aimed to answer the question of whether acellular pertussis vaccines are as effective as the whole-cell vaccines at protecting children against whooping cough (pertussis), but with fewer side effects. Background Whooping cough can be a serious respiratory infection in children and is caused by the bacterium Bordetella pertussis ...
  4. 17 Sep 2014
    Antigen-specific active immunotherapy for ovarian cancer Updated
    Background Ovarian cancer is the leading cause of death from gynaecological cancers. Standard therapy consists of surgery and chemotherapy. Responses to chemotherapy are generally good, however, the majority of women will relapse, for which no curative treatment is available. The presence of certain immune cells in tumours is associated with longer ...
  5. 17 Sep 2014
    Opioids for osteoarthritis Updated
    This summary of a Cochrane review of 22 studies with 8275 participants (search update: 15 August 2012) presents what we know from research about the effect of opioids on osteoarthritis (OA). We searched scientific databases for clinical trials looking at pain, function, safety, and addiction of oral or transdermal opioids compared with placebo or no ...
  6. 17 Sep 2014
    Repetitive transcranial magnetic stimulation (rTMS) for panic disorder New
    Why is this review important? Panic disorder is a common mental disorder and its lifetime prevalence is 5.1%. The major characteristic of panic disorder is the occurrence of unexpected panic attacks with consequent anxiety about experiencing another attack. Despite major advances in the treatment, many people with panic disorder do not respond well ...
  7. 16 Sep 2014
    Non-steroidal anti-inflammatory drugs (NSAIDs) for acute gout New
    What is an acute gout flare and what are NSAIDs? Gout results from the deposition of crystals of uric acid in and around joints. Gout usually presents as self limited episodes of acute arthritis. NSAIDs are drugs that reduce pain and inflammation, but may increase the risk of gastrointestinal ulcers and bleeding. COX-2 selective inhibitors (COXIBs) ...
  8. 15 Sep 2014
    Steroid avoidance or withdrawal for pancreas and pancreas with kidney transplant recipients New
    People with type 1 diabetes and kidney failure have a poor survival. In the clinical course, they suffer from several diabetic vascular complications and usually have progressive kidney impairment. Pancreas transplantation improves survival and quality of life and controls blood glucose without the need for insulin therapy, making pancreas with kidney ...
  9. 15 Sep 2014
    Systemic (whole body) safety of bevacizumab versus ranibizumab for neovascular age-related macular degeneration New
    Background Neovascular age-related macular degeneration (AMD) is a progressive and chronic disease of the eye, and a leading cause of severe blindness in elderly populations. The disease is characterised by the abnormal growth of arteries and veins (neovascularisation) in the macula, a region of the retina (back portion of eye) responsible for central ...
  10. 15 Sep 2014
    A review of the ways in which healthcare professionals can be helped to involve their patients in the healthcare decision making process Updated
    When there are several treatments possible, healthcare professionals can involve patients in the process of making decisions about their care so that the patients can choose care that meets their needs and reflects what is important to them. We call this 'shared decision making'. Although the results are better when patients are involved, healthcare ...

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