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  1. 24 Jul 2014
    Topical lidocaine for neuropathic pain in adults New
    Neuropathic pain is pain coming from damaged nerves. It differs from pain messages carried along healthy nerves from damaged tissue (a fall, or cut, or arthritic knee). Neuropathic pain is treated by different medicines than pain from damaged tissue. Medicines like paracetamol or ibuprofen are usually not effective in neuropathic pain, while medicines ...
  2. 23 Jul 2014
    Bisphosphonate therapy for osteogenesis imperfecta Updated
    Osteogenesis imperfecta is also known as brittle bone disease. It is a genetic condition which can be passed on from a parent to child or occur in the child without any other family history. An affected person is at risk for frequent breaks of the long bones or collapse of the vertebral bones. There is no cure for osteogenesis imperfecta and treatment ...
  3. 23 Jul 2014
    Treatment of amblyopia (lazy eye) caused by strabismus (squint) with patching or optical treatment (glasses or penalisation) or both Updated
    Review question: Treatment of amblyopia (lazy eye) caused by strabismus (squint) with patching or optical treatment (glasses or penalisation) or both. Background: Amblyopia is a common childhood condition which causes a reduction in vision of one or both eyes which is not caused by any eye disease. Amblyopia can be caused by the presence of a squint ...
  4. 23 Jul 2014
    Statins for children with inherited high blood cholesterol Updated
    Familial hypercholesterolemia is an inherited disease in which blood cholesterol level is high. Vascular diseases often occur at an earlier age than usual, especially amongst men. Thus lifelong therapies to reduce blood cholesterol (started in childhood) are needed. In children with familial hypercholesterolemia, diet has been the main treatment option. ...
  5. 23 Jul 2014
    Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus New
    Review question We reviewed the evidence about the effect of deep anterior lamellar keratoplasty (DALK) (new technique) versus penetrating keratoplasty (standard technique) in people with keratoconus. Background Keratoconus is a disease of the cornea, which is the clear surface at the very front of the eye. In eyes with keratoconus, the cornea becomes ...
  6. 23 Jul 2014
    11C-PIB-PET scan for early prediction of developing Alzheimer’s disease or other dementia in people with mild cognitive impairment (MCI) New
    The numbers of people with dementia and other cognitive problems are increasing globally. A diagnosis of the pre-dementia phase of disease is recommended but there is no agreement on the best approach. A range of tests have been developed which healthcare professionals can use to assess people with poor memory or cognitive impairment. Based on the published ...
  7. 22 Jul 2014
    Interventions for replacing missing teeth: different types of dental implants Updated
    Review question To compare the effects of different dental implants. These are implanted into bone and vary primarily in their shape, material and type of surface. Background Missing teeth can sometimes be replaced with dental implants into the jaw, as bone can grow around the implant. A crown, bridge or denture can then be attached to the implant. ...
  8. 22 Jul 2014
    Surgical techniques involving the uterus at caesarean section Updated
    Caesarean section is a common abdominal operation for surgical delivery of a baby and the placenta. Techniques vary depending on the clinical situation and surgeon preferences. Safe delivery is important for mother and infant. Any potential reduction of birth trauma to the infant has to be balanced against increased ill-health for the mother. Factors ...
  9. 21 Jul 2014
    Endovascular treatment for ruptured abdominal aortic aneurysm Updated
    The abdominal aorta is the main artery supplying blood to the lower part of the body. An abnormal ballooning and weakening of the wall of the aorta (aortic aneurysm) particularly affects men as they grow older. An aneurysm may progressively enlarge without obvious symptoms yet it is potentially lethal as the aneurysm can burst (rupture) causing massive ...
  10. 20 Jul 2014
    The use of vibrating devices to help people with cystic fibrosis clear their airways of mucus Updated
    Review question We reviewed the evidence about the effect of vibrating devices (e.g. Flutter, acapella, cornet, Quake®, intrapulmonary percussive ventilation, high frequency chest wall oscillators (e.g. Vest), VibraLung and MetaNeb) to help people with cystic fibrosis clear their airways of mucus. Background People with cystic fibrosis have too ...

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