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  1. Angioplasty versus conservative management of intermittent claudication, leg pain on walking
    Intermittent claudication is evident as pain in the leg that becomes apparent when walking and is relieved by rest. The pain is the result of insufficient blood flow to the calf muscles when exercising, generally because of atherosclerotic changes in the leg arteries so that a section becomes narrowed or blocked. People with mild disease are advised ...
  2. Angioplasty versus stenting for subclavian artery stenosis
    The subclavian arteries are two major arteries of the upper chest, below the collar bone, that come from the arch of the aorta. The left subclavian artery supplies blood to the left arm and the right subclavian artery supplies blood to the right arm, with some branches supplying blood to the head and chest. A history of smoking, high blood pressure, ...
  3. Angioplasty versus angioplasty and stenting for lesions of the superficial femoral artery
    Intermittent claudication is pain in the leg that is brought on by walking and which is relieved by rest. The pain is a result of insufficient blood flow to the muscles of the leg due to narrowing of the arteries by atherosclerosis. Patients who have narrowing of the main artery in the thigh, the superficial femoral artery, and intermittent claudication ...
  4. Anticoagulants for intermittent claudication
    Atherosclerosis is a disease of the arteries in which fatty deposits block the flow of blood. This can cause intermittent claudication, when cramping pain in the legs is brought on by exercise and relieved by rest. These fatty deposits can also cause serious blockages that lead to heart attacks and the need for amputation (surgical removal of the limb). ...
  5. Anticoagulants compared with anti-inflammatory drugs or placebo for treating people who have venous blood clots
    A blood clot can block a venous blood vessel to cause what is known as a thromboembolism. This most often occurs in a leg (deep vein thrombosis) or in the lungs (pulmonary embolism), which can be fatal. Once formed, a blood clot in a leg can increase in size or can move to the lungs and the recommended treatment is to give drugs that thin the blood ...
  6. Antiplatelet agents for preventing failure of peripheral arterial grafts
    Symptomatic peripheral arterial disease in people with atherosclerosis can present as intermittent claudication, disabling pain on walking, or as critical limb ischaemia with pain at rest, ulceration, gangrene and the risk of losing a leg. One treatment option is to implant a graft or makeshift blood vessel to bypass a blockage in the main artery of ...
  7. Drugs to prevent the re-occurrence of narrowing of blood vessels in peripheral arterial disease after the damaged blood vessels have been widened surgically
    Peripheral arterial disease of leg arteries can progressively cause leg pain on walking, pain at rest, ulcers and gangrene because of reduced blood flow. An inflatable balloon catheter inserted into the artery is used to widen and unblock the affected artery (termed angioplasty) yet reoccurrence of narrowing (restenosis/reocclusion) frequently occurs ...
  8. Antithrombotic drugs to prevent further blood vessel blockage after bypass surgery using vein grafts obtained from the same person (autologous) or artificial grafts in the legs
    Lower limb atherosclerosis can lead to blocked blood vessels causing pain on walking (intermittent claudication) or, if more severe, pain at rest, ulceration and gangrene (critical limb ischaemia). Surgery to bypass the blockage uses either a piece of vein from another part of the person’s body or a synthetic graft. The bypass may help improve blood ...
  9. Balloon angioplasty versus medical therapy for patients with renal artery obstruction and high blood pressure
    Atherosclerosis can cause narrowing and hardening of the main blood vessel supplying the kidneys (renal artery stenosis) and resulting high blood pressure. Even using drugs that lower blood pressure (antihypertensives), atherosclerotic renal artery narrowing tends to progress. Poor blood flow results in a lack of oxygen (renal ischaemia) and loss of ...
  10. Beta blockers for peripheral arterial disease
    Intermittent claudication is the most common symptom of atherosclerotic peripheral arterial disease and results from decreased blood flow to the legs during exercise. Beta blockers are a large group of drugs that have been shown to decrease deaths in people with high blood pressure and coronary artery disease and are used to treat a number of disorders. ...

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