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  1. 3 Dec 2013
    Methods that might help to keep people in randomised trials Podcast
    Background Most trials follow people up to collect data through personal contact after they have been recruited. Some trials get data from other sources, such as routine collected data or disease registers. There are many ways to collect data from people in trials, and these include using letters, the internet, telephone calls, text messaging, face-to-face ...
  2. 11 Sep 2013
    Search strategies to identify diagnostic accuracy studies in MEDLINE and EMBASE
    A diagnostic test is any kind of medical test performed to help with the diagnosis or detection of a disease. A systematic review of a particular diagnostic test for a disease aims to bring together and assess all the available research evidence. Bibliographic databases are usually searched by combining terms for the disease with terms for the diagnostic ...
  3. 31 Jul 2013
    Industry sponsorship and research outcome Podcast
    Results from clinical studies on drugs and medical devices affect how doctors practice medicine and thereby the treatments offered to patients. However, clinical research is increasingly sponsored by companies that make these products, either because the companies directly perform the studies, or fully or partially fund them. Previous research has found ...
  4. 31 Jan 2013
    CONsolidated Standards Of Reporting Trials (CONSORT) and the completeness of reporting of randomised controlled trials published in medical journals
    A group of experts has developed a checklist and flow diagram called the CONSORT Statement. The checklist is designed to help authors in the reporting of randomised controlled trials (RCTs). This systematic review aims to determine whether the CONSORT Statement has made a difference to the completeness of reporting of RCTs. Reporting of RCTs published ...
  5. 17 Oct 2012
    New treatments versus established treatments in randomized trials Podcast
    Random allocation to different groups to compare the effects of treatments is used in fair tests to find out which among the treatment options is preferable. Random allocation is only ethical, however, if there is genuine uncertainty about which of the treatment options is preferable. If a patient or their healthcare provider is certain which of the ...
  6. 9 Nov 2011
    Methods for obtaining unpublished data Podcast
    This methodology review was conducted to assess the effects of different methods for obtaining unpublished studies (data) and missing data from studies to be included in systematic reviews. Six studies met the inclusion criteria, two were randomised studies and four were observational comparative studies evaluating different methods for obtaining missing ...
  7. 5 Oct 2011
    Strategies to recruit participants to randomised trials
    Many trials do not recruit sufficient participants and this can make it more difficult to use the results of the research in practice. Effective strategies for improving recruitment would be of great benefit to researchers designing and running trials. This review did find some strategies that can increase recruitment to trials. Researchers could telephone ...
  8. 7 Sep 2011
    Blinded versus unblinded assessments of risk of bias in studies included in a systematic review
    When researchers want to answer a question they can use an approach called a systematic review, which is intended to examine all of the studies that have been done in a particular area of interest. When examining and summarizing the literature, researchers are expected to determine which of the studies were well-conducted (i.e. high quality) and those ...
  9. 10 Aug 2011
    Examining reference lists to find relevant studies for systematic reviews
    Systematic reviews are summaries of the information that is available on one topic. The most common way to find information for a systematic review is to search electronic literature databases. To increase the chances of finding important information, researchers can also search the tables of contents of journals, and they can contact experts or organizations ...
  10. 13 Apr 2011
    Randomised controlled trials as a safeguard against biased estimates of treatment effects
    Randomised controlled trials (RCTs) use the play of chance to allocate participants to comparison groups to prevent selection bias. Other means of treatment allocation are more prone to bias because decisions about which treatment to use can be influenced by the preferences of the physician or patient. This review compares random allocation (allocated ...

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