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Waldenstrom's macroglobulinaemia (WM) is an uncommon B-cell lymphoproliferative disorder characterised by bone marrow infiltration and production of monoclonal immunoglobulin. It is a kind of non-Hodgkin's lymphoma which can lead to death. Alkylating agents are believed to be effective in treatment of Waldenstrom's macroglobulinaemia for alleviating ...

An area of uncertainty in the care of patients with acute lymphoblastic leukemia (ALL) is the choice of treatment that is given after a complete remission is achieved with induction chemotherapy. Therapeutic alternatives include consolidation chemotherapy, autologous transplant (transplantation of a patient's own stem cells) or allogeneic transplant ...

Multiple myeloma (also known as myeloma or plasma cell myeloma) is a B-cell malignancy, or more precisely, plasma cell neoplasm. Multiple myeloma cells migrate to the bone marrow and continuously multiply. Thus, the cancer grows inside or outside of the bones. The bone damage, or osteolytic lesions, may lead to fractures of the long bones or compression ...

Blood stem cells are collected from a donor in two ways: either through a bone marrow harvest (direct retrieval of the stem cells from the donor's hip bones, under general anaesthetic) or a peripheral blood stem cell collection (retrieval of stem cells using a blood cell separator machine, following a course of granulocyte colony stimulating factor ...

Study design: Meta-analysis of seven randomised controlled trials involving 1943 patients.Contribution: Patients treated with R-chemo had better overall survival, overall response, complete response, and disease control but more leukocytopenia and fever than patients treated with chemotherapy alone. R-chemo improved overall survival in patients with ...

Hodgkin's disease (HD) patients are usually treated initially with radiotherapy alone (RT; early stages only), chemotherapy alone (CT) or combined chemo-radiotherapy (CRT). A meta-analysis of data from 37 randomised trials including over 9000 patients was conducted. For early-stage patients, CRT resulted in longer survival and longer HD-free survival ...

Acute myelogenous leukemia (AML) is an aggressive, rare type of blood cancer manifested by infections, bleeding and a high rate of mortality. It requires immediate treatment with intensive chemotherapy and sometimes also with bone marrow transplantation. Infections are a major cause of mortality in AML patients since intensive chemotherapy lowers the ...

Hodgkin lymphoma is a malignancy of the lymphatic system. It is one of the most common cancers in young adults, particularly in their third decade of life, but it occurs also in children and elderly people. Within the last fifty years it has become one of the most curable forms of cancer. To find the best treatment with the greatest efficacy and least ...

Corticosteroids are commonly used to treat acute and chronic graft-versus-host disease (GvHD) but their effect on length and quality of life of patients has not been studied systematically. In this systematic review, we tried to compare the effect of treatment regimens used for GvHD in the absence and presence of corticosteroids, or with different doses ...

Some types of blood cancer can be treated by transplanting stem cells from the patient's blood relatives or siblings. Unfortunately, transplanted stem cells (also called the 'graft') can sometimes induce an inflammatory reaction in the patient (or the 'host'). This reaction is called 'graft-versus-host disease' (GvHD), and once it occurs it is difficult ...