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  1. 8 Jan 2014
    Do medications used to treat depression help smokers who are trying to quit
    Background and review questions Some medications and supplements that have been used to treat depression (antidepressants) have been tested to see whether they also help people who are trying to stop smoking. Two antidepressants, bupropion (Zyban) and nortriptyline, are sometimes prescribed to help with quitting smoking. This review set out to ...
  2. 6 Jun 2013
    Can nicotine receptor partial agonists, including cytisine, dianicline and varenicline, help people to stop smoking? Podcast
    When people stop smoking they experience cravings to smoke and unpleasant mood changes. Nicotine receptor partial agonists aim to reduce withdrawal symptoms and smoking satisfaction. Two recent trials of cytisine (937 people) confirm that it can be an effective and affordable treatment for smoking cessation. Quit rates were low, however, at around 9% ...
  3. 6 Jun 2013
    Do opioid antagonists such as naltrexone help people to stop smoking?
    Opioid antagonists are a type of drug which blunts the effects of narcotics such as heroin and morphine, and might help reduce nicotine addiction by blocking some of the rewarding effects of smoking. Our review identified eight trials of naltrexone, a long-acting opioid antagonist. The trials included over 1200 smokers. Half the trials gave everyone ...
  4. 31 May 2013
    Medications to help people to stop smoking: an overview of reviews
    Background Smoking is a main cause of early death throughout the world. There are a number of medications which can help people to quit smoking. Three of these, nicotine replacement therapy (NRT), bupropion and varenicline, are licensed for this purpose in the USA and Europe. Cytisine (similar to varenicline) is licensed for use in Russia and Eastern ...
  5. 28 Mar 2013
    Does more support increase success amongst people using medications to quit smoking?
    Medications (including all types of nicotine replacement therapy, bupropion and varenicline) have been shown to help people quit smoking. It has been unclear how much additional benefit is gained from also providing behavioural support, such as counselling or a telephone quitline. Combined results from 38 trials suggests that increasing the amount of ...
  6. 28 Feb 2013
    Does Nicobrevin help people to stop smoking
    Nicobrevin is a proprietary product containing quinine, menthyl valerate, camphor and eucalyptus oil marketed as an aid to smoking cessation. No randomised trials with long-term follow-up of smoking status were identified, so there was no evidence to assess efficacy.
  7. 12 Dec 2012
    Does a combination of smoking cessation medication and behavioural support help smokers to stop? Podcast
    Behavioural support (such as brief advice and counselling) and medications (including varenicline, bupropion, and nicotine replacement therapies like patches or gum) help people quit smoking. Many guidelines recommend combining medication and behavioural support to help people stop smoking, but it is unclear if some combinations are more effective than ...
  8. 14 Nov 2012
    Can nicotine replacement therapy (NRT) help people quit smoking?
    NRT aims to reduce withdrawal symptoms associated with stopping smoking by replacing the nicotine from cigarettes. NRT is available as skin patches that deliver nicotine slowly, and chewing gum, nasal and oral sprays, inhalers, and lozenges/tablets, all of which deliver nicotine to the brain more quickly than from skin patches, but less rapidly than ...
  9. 14 Nov 2012
    Can nicotine vaccines help people stop smoking or help stop recent quitters from relapsing? Podcast
    Nicotine is the main addictive component in tobacco. When a person smokes a cigarette, nicotine causes chemicals in the brain to be released, which gives a feeling of reward to the smoker. This reward is part of the reason why people keep smoking. Nicotine vaccines are designed to work by reducing the effects of nicotine on the brain, meaning the smoker ...
  10. 12 Sep 2012
    Does silver acetate help people stop smoking
    Silver acetate products (gum, lozenge, and spray) produce an unpleasant metallic taste when combined with cigarettes, so they are used as a form of aversion therapy for smoking. However, the review of trials found little evidence to show that silver acetate helps smokers quit. Any beneficial effect of silver acetate is likely to be very small, and less ...

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