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  1. 7 Jul 2014
    Interventions to increase influenza (flu) vaccination uptake for people aged 60 and older Updated
    Many health authorities recommend influenza vaccination of older people. However, vaccination uptake in people aged 60 and older varies across countries, socioeconomic and health-risk groups. It is important to identify effective interventions to increase influenza vaccination uptake. We included 57 randomised controlled trials (RCTs) with 896,531 participants ...
  2. 17 Jun 2014
    Bronchodilators for bronchiolitis for infants with first-time wheezing Updated
    What is bronchiolitis? Bronchiolitis is an acute, highly contagious, viral infection of the lungs that is common in infants 0 to 12 months of age. It occurs every year in the winter months. It causes the small airways in the lungs to become inflamed and fill with debris. The airways are narrowed and this leads to blocking of the free passage of air. ...
  3. 26 May 2014
    Comparing treatment of non-severe pneumonia in children aged 2 to 59 months with and without antibiotics
    Background Pneumonia is an infection of the lungs. In children it is one of the leading causes of childhood deaths across the globe. Pneumonia can be classified based on the World Health Organization (WHO) guidelines. This classification involves assessment of certain clinical signs and symptoms and the severity of disease. The treatment is then tailored ...
  4. 22 May 2014
    Palivizumab vaccine for prevention of respiratory syncytial virus infection in children with cystic fibrosis
    Respiratory syncytial virus is a virus which commonly causes lung infections in infants and children. Although in most children cases are not severe, children with cystic fibrosis may be at higher risk for severe respiratory syncytial virus lung infections. During a respiratory virus season, children with cystic fibrosis are more likely to need admitting ...
  5. 5 May 2014
    Fluids for people with acute bacterial meningitis
    Review question We reviewed the evidence about the effect of differing volumes of initial fluid administration (up to 72 hours) on death and various neurological sequelae in people with acute bacterial meningitis. Background Bacterial meningitis is an infection of the fluid in the spinal cord and surrounding the brain. Antibiotics are prescribed ...
  6. 10 Apr 2014
    Regulatory information on trials of oseltamivir (Tamiflu) and zanamivir (Relenza) for influenza in adults and children
    Oseltamivir and zanamivir have been stockpiled in many countries to treat and prevent seasonal and pandemic influenza, before an influenza vaccine matched to the circulating virus becomes available. Oseltamivir is classified by the World Health Organization as an essential medicine. How this review has been approached We have updated and combined ...
  7. 1 Apr 2014
    Antibodies for preventing measles after exposure
    People who have had measles, or measles vaccine, have antibodies against the virus in their blood that protect them from developing measles should they come into contact with it. These antibodies can be extracted from blood donated by these individuals. If people without antibodies come into contact with someone who is contagious with measles, they ...
  8. 25 Mar 2014
    Steroidal anti-inflammatory medication given by mouth or injection for acute sinusitis
    Review question We reviewed the evidence about the effect of steroidal anti-inflammatory medication (i.e. corticosteroids) given by mouth or injection (i.e. systemically) compared to placebo or standard clinical care on acute attacks of nose and sinus complaints (i.e. acute sinusitis) in children and adults. Background Acute sinusitis may be caused ...
  9. 13 Mar 2014
    Vaccines to prevent influenza in healthy adults
    Review question We evaluated the effect of immunisation with influenza vaccines on preventing influenza A or B infections (efficacy), influenza-like illness (ILI) and its consequences (effectiveness), and determined whether exposure to influenza vaccines is associated with serious or severe harms. The target populations were healthy adults, including ...
  10. 11 Mar 2014
    Over-the-counter medications to help reduce cough for children and adults on antibiotics for acute pneumonia
    There are many causes of acute cough, one of which is pneumonia. Cough is burdensome and impairs quality of life. Over-the-counter (OTC) medications are commonly purchased and used by patients, and are recommended by healthcare staff as additional medications in the treatment of pneumonia. There are many classes of OTC medications for cough, such as ...

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