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  1. 24 Oct 2014
    Treatments to cure long-term infections with Burkholderia cepacia in people with cystic fibrosis New
    Review question We reviewed the evidence for antibiotic treatment to cure early infection with Burkholderia cepacia complex in people with cystic fibrosis and prevent it becoming permanent. Background Cystic fibrosis is an inherited disease and people who have this disease produce large amounts of thick mucus which is difficult to clear. This mucus ...
  2. 21 Oct 2014
    Interventions for managing asthma in pregnancy New
    Asthma is the most common disorder of the respiratory system (the organs that help you breathe) in pregnancy, affecting up to one in eight women. During pregnancy asthma can improve, worsen or remain unchanged. Poorly controlled asthma may lead to complications for mothers including pre-eclampsia (high blood pressure and protein in the urine), gestational ...
  3. 19 Oct 2014
    Non-drug management of breathing problems for children with severe physical and intellectual impairment New
    Background For a variety of reasons, some children live with very severe intellectual and physical problems; they are unable to walk or talk and require a lot of care. In this study we refer to them as children with severe global developmental delay (SGDD); this is not a specific diagnosis but is rather an 'umbrella term' used to describe a group of ...
  4. 9 Oct 2014
    Antibiotics for bronchiolitis in children under two years of age Updated
    Question We reviewed the evidence on the effect of antibiotics on clinical outcomes in children with bronchiolitis. Background Bronchiolitis is a serious respiratory illness that affects babies. It is most commonly caused by respiratory syncytial virus (RSV) and is the most common reason for hospitalisation in babies younger than six months. Babies ...
  5. 9 Oct 2014
    Antibiotics for community-acquired pneumonia in adolescent and adult outpatients Updated
    Review question This review studied the effects of antibiotics on adolescents and adults with pneumonia acquired and treated in the community (as opposed to acquiring pneumonia in hospital and/or being treated for pneumonia in hospital). The evidence is current to March 2014. Background Lower respiratory tract infection is the third leading cause ...
  6. 9 Oct 2014
    Inhaled corticosteroids for cystic fibrosis Updated
    Review question We reviewed the evidence about the effect of inhaled corticosteroids in people with cystic fibrosis. Background Repeated chest infections in people with cystic fibrosis cause inflammation and damage to the lungs which, in the long term, is the most common reason for death in people with cystic fibrosis. Inhaled corticosteroids are ...
  7. 6 Oct 2014
    Pulmonary rehabilitation for interstitial lung disease (ILD) Updated
    Review question: We reviewed available evidence on the effects of pulmonary rehabilitation on exercise capacity, shortness of breath and quality of life in people with interstitial lung disease (ILD). Background: People with ILD often have reduced exercise capacity and shortness of breath during exercise. Pulmonary rehabilitation can improve well-being ...
  8. 1 Oct 2014
    Antibiotic treatment for the prevention of Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients Updated
    Pneumocystis jiroveci is a fungus causing pneumonia mainly among patients with an impaired immune system, such as those infected with the human immunodeficiency virus (HIV), cancer patients, following organ transplantation, and patients receiving immune suppressive medications. Previous evidence shows that preventive antibiotic treatment (before the ...
  9. 22 Sep 2014
    Clinical pathways for chronic cough in children Updated
    Background Clinical pathways serve as a tool or algorithm (like a flow chart) that can be used in the treatment of patients with various chronic diseases. They provide a clear guide that assists doctors in diagnosing an illness and in making decisions with the patient about what treatment is needed or which specialists should be seen or tests ordered ...
  10. 22 Sep 2014
    Treatment of the cough in whooping cough Updated
    Review question We reviewed the evidence from 12 studies about the effect of treatments for cough in patients with whooping cough. Background We wanted to discover whether any medicines are effective at treating cough in patients with whooping cough (also known as pertussis). These medicines included pertussis immunoglobulin (antibodies to increase ...

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