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  1. 7 Aug 2014
    What are the effects of vitamins E and C, beta-carotene, selenium and glutathione on lung disease in people with cystic fibrosis? Updated
    Background Frequent chest infections in people with cystic fibrosis cause long-lasting inflammation in their lungs. Cells causing inflammation produce a kind of oxygen molecule (reactive oxygen species (ROS)) which can easily harm proteins and DNA (oxidative damage). To fight these effects, the body may produce antioxidants. The genetic defect in ...
  2. 7 Aug 2014
    Using steroids and cyclophosphamide together as a treatment for paraquat poisoning Updated
    Paraquat is an effective and widely used herbicide but is also a lethal poison. In many developing countries paraquat is widely available and inexpensive, making poisoning prevention difficult. However most of the people who become poisoned from paraquat have taken it as a means of suicide. Standard care for removing paraquat from the body involves ...
  3. 5 Aug 2014
    Pneumococcal vaccines for children and adults with cystic fibrosis Updated
    Cystic fibrosis is an inherited disease which causes mucus in the lungs to be more sticky than normal, leading to frequent lung infections and lung damage. Pneumococcus is a type of bacteria that can cause infection throughout the body, including in the urine, blood stream, fluid around the brain and in the lungs. These infections can be very serious ...
  4. 1 Aug 2014
    Is continuous positive airway pressure (CPAP) during the postoperative period useful? New
    Review question Does continuous positive airway pressure during the postoperative period help reduce death and major lung complications after major abdominal surgery? Background General anaesthesia can lead to reduced lung volumes and collapse of the alveoli as well as to reversible, patchy collapse of areas of lung (atelectasis) and subsequent ...
  5. 31 Jul 2014
    Are inhaled anticholinergics added to β2-agonists beneficial in children hospitalised with acute asthma? New
    Background: Anticholinergics (e.g. ipratropium bromide, atropine sulfate) are inhaled drugs. They relax the airway muscles and decrease secretions. Anticholinergics are sometimes used in addition to beta2-agonists (such as salbutamol and terbutaline), which are potent drugs given to relax smooth muscles in the airways in children with acute asthma. ...
  6. 21 Jul 2014
    Tiotropium for managing COPD
    Chronic obstructive pulmonary disease (COPD) is a lung disease which includes the conditions, chronic bronchitis and emphysema. It is caused by smoking or inhaled dust, which leads to blockage or narrowing of the airways. The symptoms include breathlessness and a chronic cough. Tiotropium is an inhaled medication that helps widen the airways (bronchodilator) ...
  7. 20 Jul 2014
    The use of vibrating devices to help people with cystic fibrosis clear their airways of mucus
    Review question We reviewed the evidence about the effect of vibrating devices (e.g. Flutter, acapella, cornet, Quake®, intrapulmonary percussive ventilation, high frequency chest wall oscillators (e.g. Vest), VibraLung and MetaNeb) to help people with cystic fibrosis clear their airways of mucus. Background People with cystic fibrosis have too ...
  8. 17 Jul 2014
    Is water-based exercise an effective and safe type of exercise for adults with asthma? New
    Asthma is a common condition in which inflammation and narrowing of the air conducting tubes may cause intermittent symptoms, possibly limiting activities of daily life. Some adults believe that exercise could trigger an asthma attack. However, research has shown the opposite—that adults who exercise may have less chance of having an asthma attack, ...
  9. 16 Jul 2014
    Does altering the dose of inhaled corticosteroids make a difference in growth among children with asthma? New
    Background Asthma guidelines recommend inhaled corticosteroids (ICS) as the first choice of treatment for children with persistent asthma that is not well controlled when only a reliever inhaler is used to treat symptoms. Steroids work by reducing inflammation in the lungs and are known to control underlying symptoms of asthma. However, parents and ...
  10. 16 Jul 2014
    Do inhaled corticosteroids reduce growth in children with persistent asthma?
    Review question: We reviewed the evidence on whether inhaled corticosteroids (ICS) could affect growth in children with persistent asthma, that is, a more severe asthma that requires regular use of medications for control of symptoms. Background: Treatment guidelines for asthma recommend ICS as first-line therapy for children with persistent asthma. ...

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