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  1. 29 Jul 2014
    The effectiveness of community interventions to promote condom use in the prevention of HIV and sexually transmitted infections New
    Bakground Since the advent of the HIV/AIDS epidemic in the 1980s, condom promotion has become one of the most widely used interventions to prevent transmission of HIV and sexually transmitted infections (STIs). However, despite widespread promotion of condom use globally, new cases of HIV and other STIs either remain high or continue to rise in some ...
  2. 28 Jul 2014
    Are oral antibiotics as effective as a combination of injected and oral antibiotics for kidney infections in children? Updated
    Acute pyelonephritis refers to infection of the kidneys and is the most severe form of urinary tract infection (UTI). Acute pyelonephritis causes high fever, vomiting, stomach pain, irritability and poor feeding in infants. We wanted to find out if oral antibiotics were as effective as combined oral and injected antibiotics to treat children for kidney ...
  3. 26 Jul 2014
    PRO 140 for treatment of people with HIV infection
    PRO 140 (a humanized form of the PA14 antibody, a monoclonal CCR5 antibody) is a laboratory made antibody that blocks the CCR5 receptor on CD4 cells. By blocking CCR5, PRO 140 prevents the HIV virus from infecting healthy cells. PRO 140 may be an effective new treatment drug because it has the potential to address the limitations of currently available ...
  4. 25 Jul 2014
    Should Chinese herbal medicines be used in patients with skin and soft-tissue infections? New
    What are skin and soft-tissue infections? Skin and soft-tissue infections (SSTIs) are common infections of the skin or the tissue beneath the skin. They include impetigo, abscesses, cellulitis, erysipelas, necrotising (flesh-killing) skin infections, infections caused by animal or human bites or by animal contact, and infections after surgery. Most ...
  5. 7 Jul 2014
    Interventions to increase influenza (flu) vaccination uptake for people aged 60 and older Updated
    Many health authorities recommend influenza vaccination of older people. However, vaccination uptake in people aged 60 and older varies across countries, socioeconomic and health-risk groups. It is important to identify effective interventions to increase influenza vaccination uptake. We included 57 randomised controlled trials (RCTs) with 896,531 participants ...
  6. 1 Jul 2014
    Shifting HIV care from doctors to non-doctors to improve access to therapy for people living with HIV
    Background High levels of healthcare worker shortage has limited HIV infected patients access to antiretroviral therapy in lower and middle-income countries. This occurs most where the burden of HIV disease is greatest and where access to trained doctors is limited. We wanted to assess if task shifting of care from doctors to non-doctors provides ...
  7. 30 Jun 2014
    Corticosteroids for treating dengue infection in children and adults Updated
    Dengue is a disease caused by a virus transmitted by mosquitoes, occurring in many resource-limited countries, and children are often most severely affected. Most infected patients will recover with mild symptoms, but a few progress to severe dengue and may die. There is no specific treatment for dengue, but some clinicians provide corticosteroids at ...
  8. 30 Jun 2014
    A single dose of primaquine added to malaria treatment to prevent malaria transmission Updated
    We conducted a review of the effects of adding a single dose (or short course) of primaquine to malaria treatment with the aim of reducing the transmission of malaria. We included 17 randomized controlled trials and one quasi-randomized controlled trial. What is primaquine and how might it reduce transmission Primaquine is an antimalarial drug which ...
  9. 29 Jun 2014
    Zinc supplements for preventing middle ear infections Updated
    Background Middle ear infections are common, especially among young children, usually causing earache and some temporary (occasionally permanent) hearing loss. Zinc is an essential micronutrient, which has a role in the optimal functioning of the immune system and resistance to infection. It must be consumed regularly as it cannot be stored in the ...
  10. 23 Jun 2014
    Post-exposure prophylaxis vaccine to prevent varicella (chickenpox)
    Review question This review assessed how useful the varicella (also known as chickenpox) vaccine is in preventing chickenpox when given to children or adults who have never been immunised or previously had chickenpox, but who receive the vaccine within a short time following exposure to a person infectious with chickenpox. Varicella is a highly contagious ...

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