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  1. 31 Oct 2014
    Cilostazol for peripheral arterial disease Updated
    Blockages in the arteries to the legs - peripheral arterial disease - affect 20% of people over 70 years of age and 4% to 12% of the population aged 55 to 70 years. Approximately 40% of those affected with peripheral arterial disease complain of pain in the legs on walking, this is known as intermittent claudication. Intermittent claudication is characterised ...
  2. 29 Oct 2014
    Drug interventions for deliberately altering blood pressure in acute stroke Updated
    Background: In people who have just had a stroke (a sudden brain attack due to either blockage or rupture of an artery in the brain), very high and very low blood pressures may be harmful. Therefore, drugs that raise low blood pressure or lower high blood pressure might be beneficial. Up to 50% of people admitted with acute stroke are taking blood ...
  3. 15 Oct 2014
    Beta-blockers for preventing stroke recurrence Updated
    People who have had a stroke or a transient ischaemic attack (TIA) are at risk of having further strokes or heart attacks, or other serious circulatory problems. Beta-blockers are drugs that reduce heart rate and blood pressure, and have other effects that might also reduce the risks of stroke and heart attack. Searching for studies up to May 2014, ...
  4. 8 Oct 2014
    Heparin versus saline solution flushing for prevention of occlusion in central venous catheters in adults New
    Central venous catheters (CVCs) are temporary devices implanted into patients when easy or frequent intravenous access is needed. Doctors often use them. A Hickman line is an example of a CVC. A CVC is used, for instance, for monitoring patients in intensive care, or for giving chemotherapy or intravenous nutrition. However, such catheters can cause ...
  5. 18 Sep 2014
    Influence of beta-blockers on perioperative adverse events New
    Any type of surgery is associated with an increased stress response, which can make the body vulnerable to untoward outcomes. These outcomes may range from death to a heart attack and rhythm disturbances to heart failure, stroke and the like. Beta-blockers are drugs that attenuate this stress response, which results in slowing down of heart rate and ...
  6. 12 Sep 2014
    Should health care providers arriving at scene of a cardiac arrest give a period of chest compressions first before providing a rapid electric shock
    Out-of-hospital cardiac arrest (OHCA) is a major cause of death worldwide. Cardiac arrest occurs when the rhythm of the heart becomes disorganized and the heart becomes ineffective at pumping blood to the rest of the body. Prolonged periods of reduced oxygen to the brain can cause permanent damage. Cardiac arrest can be caused by, but is different from, ...
  7. 10 Sep 2014
    Delivering clot-busting therapy before reaching hospital or in hospital to help people who are having heart attacks New
    Heart disease is the most common cause of death worldwide according to the World Health Organization. A heart attack can either be treated with a drug called a thrombolytic (clot buster) or with surgery. The earlier a thrombolytic is given, the less likely the individual is to die or have disabilities. Usually, thrombolysis is given in a hospital; however, ...
  8. 9 Sep 2014
    Compression hosiery (stockings) for preventing venous leg ulcers returning Updated
    Venous leg ulcers (open wounds on the lower leg) can be caused by a blockage or breakdown in the veins of the legs. Compression, using bandages or hosiery (stockings), can help heal most of these ulcers and is also widely used after healing to prevent ulcers returning. One small trial confirms that compression reduces ulcer recurrence compared with ...
  9. 9 Sep 2014
    Oral zinc supplements for treating leg ulcers Updated
    Most leg ulcers (open sores, usually on the lower leg) usually heal with good wound care, including wound dressings. However even with good wound care leg ulcers may take weeks or months to heal. Leg ulcers often cause distress to patients and are costly for health services. Failure to heal may be due to poor nutrition which reduces the ability of the ...
  10. 1 Sep 2014
    Statins for acute coronary syndrome Podcast Updated
    Long-term therapy with statins (for at least one year) has been shown to reduce the risk of heart attack, stroke, and all-cause mortality in patients with and without established coronary heart disease. The early period following an acute coronary syndrome is a critical stage of coronary heart disease, with a high risk of recurrent events and death. ...

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