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  1. 30 Jul 2014
    Endovenous ablation (radiofrequency and laser) and foam sclerotherapy versus open surgery for varicose veins Updated
    Varicose veins are dilated, tortuous superficial veins. When they are in the legs they can be painful, itchy or unsightly, especially when patients are standing and walking. Varicose veins are conventionally treated with surgery to remove the veins, by stripping them to the level of the knee (so-called high ligation and stripping). New less invasive ...
  2. 29 Jul 2014
    Continuous passive motion therapy for preventing venous thromboembolism after total knee replacement (arthroplasty) Updated
    Total knee arthroplasty (TKA) is a common form of orthopaedic surgery that can improve the quality of life for patients. Patients who receive joint replacement are particularly susceptible to developing deep vein thrombosis (DVT) and pulmonary embolism (PE) because of tissue damage, surgical stress, immobility and muscle weakness following the surgery. ...
  3. 29 Jul 2014
    Clot-dissolving drugs for treating ischaemic stroke in the early stages Podcast Updated
    Question We wanted to compare the safety and efficacy of clot-dissolving (thrombolytic) drugs versus placebo or no treatment in the early stages of ischaemic stroke to see if clot-dissolving drugs improve outcome after stroke. Background Most strokes are due to blockage of an artery in the brain by a blood clot. Prompt treatment with clot-dissolving ...
  4. 21 Jul 2014
    Endovascular treatment for ruptured abdominal aortic aneurysm Updated
    The abdominal aorta is the main artery supplying blood to the lower part of the body. An abnormal ballooning and weakening of the wall of the aorta (aortic aneurysm) particularly affects men as they grow older. An aneurysm may progressively enlarge without obvious symptoms yet it is potentially lethal as the aneurysm can burst (rupture) causing massive ...
  5. 18 Jul 2014
    Exercise for reducing intermittent claudication symptoms Updated
    Intermittent claudication is a cramping leg pain that develops when walking and is relieved with rest. It is caused by inadequate blood flow to the leg muscles because of atherosclerosis (fatty deposits restricting blood flow through the arteries). People with mild-to-moderate claudication are advised to keep walking, stop smoking and reduce cardiovascular ...
  6. 18 Jul 2014
    Does the speed of injection make a difference to the amount of pain and bruising in people having heparin injections? New
    Heparin is a drug used to help stop blood from clotting. It comes in two forms - unfractionated heparin and low molecular weight heparin. These are usually given by injection just underneath the skin. The heparin goes into the layer of fat under the skin so that it is released slowly into the body.This type of injection can sometimes cause bruising ...
  7. 8 Jul 2014
    Blood thinners for the long-term treatment of blood clots in patients with cancer Updated
    Background Patients with cancer are at an increased risk of developing blood clots and might respond differently to blood thinners (anticoagulants) compared with patients without cancer. Study characteristics We searched scientific databases for clinical trials looking at the effects of long-term treatment with different blood thinners on blood ...
  8. 4 Jul 2014
    Modes of exercise training for intermittent claudication New
    Intermittent claudication is a cramping leg pain that develops during exercise and is relieved by a short period of rest. It is caused by inadequate blood flow to the muscles of the leg because of atherosclerosis (hardening and narrowing of the arteries). Intermittent claudication is closely associated with other vascular diseases, such as a heart attack ...
  9. 1 Jul 2014
    Oral blood thinners in patients with cancer Updated
    Background This review assessed the effects of oral anticoagulation (blood-thinning drugs) in people with cancer on survival, thromboembolic events, and bleeding outcomes. Study characteristics We searched the scientific literature for studies of anticoagulants in people with cancer. The evidence is current to February 2013. Key results We found ...
  10. 27 Jun 2014
    Heparins reduce the number of heart attacks but caused more minor bleeding after non-ST elevation acute coronary syndromes compared with placebo Podcast
    Blood clots in the arteries leading to the heart can cause acute coronary syndromes: unstable angina (a feeling of tightness in the chest) or a type of heart attack (non-ST segment myocardial infarction - NSTEMI). Drugs that prevent clots from forming (such as aspirin) or thin the blood (such as heparin) can relieve the problem. Unfractionated heparin ...

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