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  1. 15 Apr 2014
    Fixed-dose combination therapy for the prevention of cardiovascular disease New
    Cardiovascular diseases (CVD), including heart attacks and strokes, are the leading cause of death and disability worldwide. Drug therapy with blood pressure and cholesterol lowering medications, particularly statins, have been proven to reduce the likelihood that individuals will experience a fatal or non-fatal cardiovascular event. Aspirin has also ...
  2. 14 Apr 2014
    Shengmai (a traditional Chinese herbal medicine) for heart failure Updated
    Heart failure is a major public health issue worldwide. Despite advances in treatment, many people are affected and hundreds of thousand of people die each year. Shengmai is a traditional Chinese herbal medicine and is a mixture extracted from three herbs: Panax ginseng, Ophiopogon japonicus and Schisandra chinensis. In China it has been used to treat ...
  3. 9 Apr 2014
    Tai Chi to prevent cardiovascular disease New
    Background Cardiovascular diseases (CVD) are a group of conditions that affect the heart and blood vessels that are a worldwide health burden. However, it is thought that CVD risk can be lowered by changing a number of modifiable behaviours including increasing levels of exercise, and relaxation to reduce stress levels, and both of these comprise ...
  4. 8 Apr 2014
    Type of incision used for below knee amputation to create a skin flap that maximises healing Updated
    Below knee amputation may be necessary for people with critical limb ischaemia caused by advanced vascular disease or diabetic foot infection (sepsis) where no other treatment option is possible. Keeping the knee joint gives a better chance of walking using an artificial leg or prosthesis and social independence after the amputation. The surgical technique ...
  5. 7 Apr 2014
    Screening for peripheral arterial disease New
    Peripheral arterial disease (PAD) is caused by fatty deposits on the walls of the arteries (or atherosclerosis) that leads to narrowing of the arteries (or stenosis) and obstructions in the major vessels supplying the lower legs. PAD can cause discomfort or pain in the lower legs when walking. People with PAD have an increased risk of death, heart and ...
  6. 28 Mar 2014
    There is not enough evidence to determine if anticoagulants safely prevent blood clots in patients with chronic heart failure who are in normal heart rhythm Updated
    Blood clots (thromboembolism) in the lungs, legs and brain (ischaemic stroke) contribute to disability and the death of patients with heart failure. Although anticoagulants such as warfarin are of proven benefit in patients in certain subgroups of patients with heart failure, such as those with atrial fibrillation, there is little evidence that warfarin ...
  7. 27 Mar 2014
    Direct thrombin inhibitors compared with vitamin K antagonists in people with atrial fibrillation for preventing stroke New
    Question: We wanted to compare the effectiveness and safety of direct thrombin inhibitors (DTIs) with vitamin K antagonists in people with atrial fibrillation (AF) to prevent stroke. Background: Non-valvular atrial fibrillation is a type of irregular heartbeat that arises in a heart with normal valves. It increases the risk of developing blood clots ...
  8. 25 Mar 2014
    Oral antiplatelet therapy for acute ischaemic stroke Updated
    Question We wanted to compare the safety and effectiveness of oral antiplatelet therapy versus placebo or no treatment in people with acute ischaemic stroke to see if oral antiplatelet drugs reduced the number of deaths and improved the long-term outcomes in survivors. Background Most strokes are caused by a sudden blockage of an artery in the brain ...
  9. 17 Mar 2014
    Atherectomy for peripheral arterial disease New
    A person with diseased arteries in the legs can experience pain on walking (also known as intermittent claudication), pain at rest (especially at night), or ulcers due to poor blood flow. Established treatments include surgery, where a bypass is inserted to carry blood from an artery above the diseased (blocked or narrowed) section to below the diseased ...
  10. 10 Mar 2014
    Blood thinners for the prevention of blood clots in children with central venous lines New
    Over the last 10 years, the number of children found to have blood clots in their blood vessels, called veins, has become more common. As blood clots can either block these vessels and change their normal blood flow or shower pieces into other veins placed in important organs, serious health problems including death can occur. Venous clots are usually ...

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