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  1. 19 Dec 2014
    Treatment of reduced blood flow to the legs using mononuclear cell therapy Updated
    Background Critical limb ischaemia occurs when blood flow to the legs is reduced because of the worsening of peripheral arterial disease. Initially, patients experience cramping leg pain that limits walking (termed intermittent claudication), but over time some patients experience more severe symptoms including pain at rest, leg ulceration and gangrene. ...
  2. 18 Dec 2014
    Reduced dietary salt for the prevention of cardiovascular disease Updated
    Cardiovascular disease includes heart attacks and strokes and is a major cause of premature death and disability. This is an update of a review first published in 2011. This review sets out to assess whether intensive support and encouragement to cut down on salt in foods, and substituting low-sodium salt, reduces the risk of death or cardiovascular ...
  3. 18 Dec 2014
    Statins for preventing blood clot formation within veins Updated
    Background Venous thrombosis or thromboembolism (VTE) is a condition in which a blood clot (thrombus) forms in a vein and causes a blockage. The blockage most commonly occurs in the 'deep veins' of the lower legs, thighs or pelvis and is called deep vein thrombosis (DVT). If part of or the entire clot breaks away and is carried through the blood (venous) ...
  4. 18 Dec 2014
    Modifying therapies such as biologics, colchicine, corticosteroids, immunosuppressants and interferon-alpha for Neuro-Behçet's Syndrome New
    Neuro-Behçet Syndrome (NBS) is an invalidating condition with a huge impact on quality of life. Recommendations on treatments for NBS include the use of disease-modifying therapies such as biologics, colchicine, corticosteroids, immunosuppressants and interferon-alpha. To assess their benefit and harms, the review authors decided to perform a systematic ...
  5. 17 Dec 2014
    Graduated compression stockings for prevention of deep vein thrombosis during a hospital stay Updated
    Hospital patients can develop deep vein thrombosis (DVT) in the legs and pelvic veins immediately after surgery or if they are not mobile because of a medical illness. Symptoms vary from none to pain and swelling in the legs. A blood clot can move from the leg to the lungs, with the danger of pulmonary embolism (PE) and death. Usually the DVT clears ...
  6. 16 Dec 2014
    Educating people with diabetes about foot care to help reduce foot ulcers and amputations Updated
    Foot ulcers (open sores) are common in people with diabetes, especially those with problems in the nerves (peripheral neuropathy), the blood supply to their legs (peripheral vascular disease (PVD)), or both. People with ulcers due to diabetes sometimes need an amputation (surgical removal of part of the limb). Foot ulcers not only lead to physical disability ...
  7. 12 Dec 2014
    Participation in rehabilitation programmes that include regular exercise, can improve the quality of life for people with heart disease New
    Background Cardiac rehabilitation (CR) seeks to improve the function, health-related quality of life and well-being of people with heart disease through a combination of activities, in particular exercise training alongside educational and psychological support. Since the mid-2000s, the number of published Cochrane reviews has grown to six systematic ...
  8. 10 Dec 2014
    Injectable blood thinners (anticoagulants) in patients with cancer Updated
    Background Research evidence suggests that blood thinners may improve the survival of patients with cancer. This benefit could be related to a direct antitumor effect in addition to preventing blood clots. Study characteristics We searched the scientific literature for studies of anticoagulants in people with cancer. The evidence is current to February ...
  9. 5 Dec 2014
    Balloon angioplasty versus medical therapy for patients with renal artery obstruction and high blood pressure Updated
    Atherosclerosis can cause narrowing and hardening of the main blood vessel supplying the kidneys (renal artery stenosis) resulting in high blood pressure. Even using drugs that lower blood pressure (antihypertensives) atherosclerotic renal artery narrowing tends to progress. Poor blood flow results in a lack of oxygen (renal ischaemia) and loss of kidney ...
  10. 4 Dec 2014
    Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease New
    Cardiovascular disease (CVD) is the result of complications of the heart and blood vessels and is a worldwide healthcare burden. However, it is thought that CVD risk can be lowered by changing a number of modifiable risk factors, such as diet. Dietary supplements have received a great deal of attention for the prevention of CVD. One such supplement ...

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