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  1. 21 Nov 2014
    The effect of rosuvastatin on cholesterol New
    Rosuvastatin (Crestor) is one of the most potent statins and is currently widely prescribed. It is therefore important to know how much rosuvastatin lowers cholesterol. We searched for all the trial evidence from trials of three to 12 week duration reporting the effect of rosuvastatin on cholesterol. We found 108 trials involving 19,596 participants. ...
  2. 20 Nov 2014
    Outpatient versus inpatient treatment for acute pulmonary embolism New
    Background Pulmonary embolism (PE) is a common life-threatening cardiovascular condition, with 23 to 69 new cases per 100,000 people per year. Outpatient treatment instead of traditional inpatient treatment in selected low-risk patients with acute (sudden-onset) PE might provide several advantages such as reduction of hospital admissions, substantial ...
  3. 12 Nov 2014
    Hyperbaric oxygen therapy for treating people with acute ischaemic stroke Updated
    Question We wanted to compare the safety and effectiveness of hyperbaric oxygen therapy (HBOT) versus no HBOT (either no treatment or an ineffective intervention designed to mimic the true treatment) for treating people who had suffered an acute ischaemic stroke. Background Hyperbaric oxygen therapy (HBOT) is a treatment designed to increase the ...
  4. 11 Nov 2014
    Interventions to improve arm and hand function in people after stroke New
    Research question Which interventions help to promote arm and hand recovery after a person has had a stroke? Background Problems with arm function (upper limb impairments) are very common after a stroke. These upper limb impairments commonly include difficulty moving and co-ordinating the arms, hands and fingers, often resulting in difficulty carrying ...
  5. 31 Oct 2014
    Cilostazol for peripheral arterial disease Updated
    Blockages in the arteries to the legs - peripheral arterial disease - affect 20% of people over 70 years of age and 4% to 12% of the population aged 55 to 70 years. Approximately 40% of those affected with peripheral arterial disease complain of pain in the legs on walking, this is known as intermittent claudication. Intermittent claudication is characterised ...
  6. 29 Oct 2014
    Drug interventions for deliberately altering blood pressure in acute stroke Updated
    Background: In people who have just had a stroke (a sudden brain attack due to either blockage or rupture of an artery in the brain), very high and very low blood pressures may be harmful. Therefore, drugs that raise low blood pressure or lower high blood pressure might be beneficial. Up to 50% of people admitted with acute stroke are taking blood ...
  7. 15 Oct 2014
    Beta-blockers for preventing stroke recurrence Updated
    People who have had a stroke or a transient ischaemic attack (TIA) are at risk of having further strokes or heart attacks, or other serious circulatory problems. Beta-blockers are drugs that reduce heart rate and blood pressure, and have other effects that might also reduce the risks of stroke and heart attack. Searching for studies up to May 2014, ...
  8. 8 Oct 2014
    Heparin versus saline solution flushing for prevention of occlusion in central venous catheters in adults New
    Central venous catheters (CVCs) are temporary devices implanted into patients when easy or frequent intravenous access is needed. Doctors often use them. A Hickman line is an example of a CVC. A CVC is used, for instance, for monitoring patients in intensive care, or for giving chemotherapy or intravenous nutrition. However, such catheters can cause ...
  9. 18 Sep 2014
    Influence of beta-blockers on perioperative adverse events
    Any type of surgery is associated with an increased stress response, which can make the body vulnerable to untoward outcomes. These outcomes may range from death to a heart attack and rhythm disturbances to heart failure, stroke and the like. Beta-blockers are drugs that attenuate this stress response, which results in slowing down of heart rate and ...
  10. 12 Sep 2014
    Should health care providers arriving at scene of a cardiac arrest give a period of chest compressions first before providing a rapid electric shock
    Out-of-hospital cardiac arrest (OHCA) is a major cause of death worldwide. Cardiac arrest occurs when the rhythm of the heart becomes disorganized and the heart becomes ineffective at pumping blood to the rest of the body. Prolonged periods of reduced oxygen to the brain can cause permanent damage. Cardiac arrest can be caused by, but is different from, ...

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