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  1. 27 Oct 2014
    Decongestants, antihistamines and nasal irrigation for acute sinusitis in children Updated
    Review question The goal of this review was to determine whether there is any evidence in the medical literature for or against the use of decongestants, antihistamines and nasal irrigation for acute sinusitis in children. Background Young children experience an average of six to eight colds per year. Out of every 10 children with a cold, one develops ...
  2. 24 Oct 2014
    Treatments to cure long-term infections with Burkholderia cepacia in people with cystic fibrosis New
    Review question We reviewed the evidence for antibiotic treatment to cure early infection with Burkholderia cepacia complex in people with cystic fibrosis and prevent it becoming permanent. Background Cystic fibrosis is an inherited disease and people who have this disease produce large amounts of thick mucus which is difficult to clear. This mucus ...
  3. 19 Oct 2014
    Non-drug management of breathing problems for children with severe physical and intellectual impairment New
    Background For a variety of reasons, some children live with very severe intellectual and physical problems; they are unable to walk or talk and require a lot of care. In this study we refer to them as children with severe global developmental delay (SGDD); this is not a specific diagnosis but is rather an 'umbrella term' used to describe a group of ...
  4. 9 Oct 2014
    Antibiotics for bronchiolitis in children under two years of age Updated
    Question We reviewed the evidence on the effect of antibiotics on clinical outcomes in children with bronchiolitis. Background Bronchiolitis is a serious respiratory illness that affects babies. It is most commonly caused by respiratory syncytial virus (RSV) and is the most common reason for hospitalisation in babies younger than six months. Babies ...
  5. 9 Oct 2014
    Inhaled corticosteroids for cystic fibrosis Updated
    Review question We reviewed the evidence about the effect of inhaled corticosteroids in people with cystic fibrosis. Background Repeated chest infections in people with cystic fibrosis cause inflammation and damage to the lungs which, in the long term, is the most common reason for death in people with cystic fibrosis. Inhaled corticosteroids are ...
  6. 1 Oct 2014
    Antibiotic treatment for the prevention of Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients Updated
    Pneumocystis jiroveci is a fungus causing pneumonia mainly among patients with an impaired immune system, such as those infected with the human immunodeficiency virus (HIV), cancer patients, following organ transplantation, and patients receiving immune suppressive medications. Previous evidence shows that preventive antibiotic treatment (before the ...
  7. 22 Sep 2014
    Clinical pathways for chronic cough in children Updated
    Background Clinical pathways serve as a tool or algorithm (like a flow chart) that can be used in the treatment of patients with various chronic diseases. They provide a clear guide that assists doctors in diagnosing an illness and in making decisions with the patient about what treatment is needed or which specialists should be seen or tests ordered ...
  8. 22 Sep 2014
    Treatment of the cough in whooping cough Updated
    Review question We reviewed the evidence from 12 studies about the effect of treatments for cough in patients with whooping cough. Background We wanted to discover whether any medicines are effective at treating cough in patients with whooping cough (also known as pertussis). These medicines included pertussis immunoglobulin (antibodies to increase ...
  9. 17 Sep 2014
    Acellular vaccines for preventing whooping cough (pertussis) in children
    Review question We aimed to answer the question of whether acellular pertussis vaccines are as effective as the whole-cell vaccines at protecting children against whooping cough (pertussis), but with fewer side effects. Background Whooping cough can be a serious respiratory infection in children and is caused by the bacterium Bordetella pertussis ...
  10. 15 Sep 2014
    Rapid viral testing for children in the Emergency Department with fever and respiratory symptoms Updated
    Review question Does rapid viral testing in the Emergency Department influence the treatment of children with fever and breathing symptoms? Background Otherwise healthy children, aged 0 to 18 years, admitted to Emergency Departments (EDs) with fever and respiratory symptoms represent a major burden to the healthcare system, as well as significant ...

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