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  1. 31 Jul 2014
    Are inhaled anticholinergics added to β2-agonists beneficial in children hospitalised with acute asthma? New
    Background: Anticholinergics (e.g. ipratropium bromide, atropine sulfate) are inhaled drugs. They relax the airway muscles and decrease secretions. Anticholinergics are sometimes used in addition to beta2-agonists (such as salbutamol and terbutaline), which are potent drugs given to relax smooth muscles in the airways in children with acute asthma. ...
  2. 20 Jul 2014
    The use of vibrating devices to help people with cystic fibrosis clear their airways of mucus Updated
    Review question We reviewed the evidence about the effect of vibrating devices (e.g. Flutter, acapella, cornet, Quake®, intrapulmonary percussive ventilation, high frequency chest wall oscillators (e.g. Vest), VibraLung and MetaNeb) to help people with cystic fibrosis clear their airways of mucus. Background People with cystic fibrosis have too ...
  3. 16 Jul 2014
    Do inhaled corticosteroids reduce growth in children with persistent asthma? New
    Review question: We reviewed the evidence on whether inhaled corticosteroids (ICS) could affect growth in children with persistent asthma, that is, a more severe asthma that requires regular use of medications for control of symptoms. Background: Treatment guidelines for asthma recommend ICS as first-line therapy for children with persistent asthma. ...
  4. 16 Jul 2014
    Does altering the dose of inhaled corticosteroids make a difference in growth among children with asthma? New
    Background Asthma guidelines recommend inhaled corticosteroids (ICS) as the first choice of treatment for children with persistent asthma that is not well controlled when only a reliever inhaler is used to treat symptoms. Steroids work by reducing inflammation in the lungs and are known to control underlying symptoms of asthma. However, parents and ...
  5. 18 Jun 2014
    Psychological treatments to help individuals with cystic fibrosis and their caregivers manage the disease
    Cystic fibrosis is a genetic disorder that damages many of the body's organs and can shorten a person's life span. The disease is progressive, stressful to manage, and needs complex and time-consuming treatments, leaving patients and caregivers stressed due to the challenges of the treatment. Thus, individuals with cystic fibrosis and their family members ...
  6. 17 Jun 2014
    Bronchodilators for bronchiolitis for infants with first-time wheezing
    What is bronchiolitis? Bronchiolitis is an acute, highly contagious, viral infection of the lungs that is common in infants 0 to 12 months of age. It occurs every year in the winter months. It causes the small airways in the lungs to become inflamed and fill with debris. The airways are narrowed and this leads to blocking of the free passage of air. ...
  7. 17 Jun 2014
    Vitamins C and E for asthma and exercise-induced breathlessness
    Review question We considered in this review whether vitamins C and E, when taken together daily, may be helpful for people with asthma or exercise-induced breathlessness. Background Asthma is an inflammatory lung condition characterised by narrowing of the airways; it is associated with breathlessness, chest tightness, cough and wheezing. The condition ...
  8. 10 Jun 2014
    The effects of singing on lung function and quality of life in children and adults with cystic fibrosis
    People with cystic fibrosis are at risk of chest infections due to abnormally thick mucus in their airways. Airway clearance is therefore an important part of cystic fibrosis management. Increasing anecdotal reports suggests that singing may support lung function and enhance quality of life in people with cystic fibrosis. We searched for trials using ...
  9. 10 Jun 2014
    Combined ICS-LABA for children and adults with bronchiectasis
    A paucity of evidence is available to allow conclusions on whether combined inhaled corticosteroids (ICS)-long-acting beta2-agonists (LABA) are equivalent or superior to placebo or ICS monotherapy for the treatment of stable or exacerbation (flare-up) state bronchiectasis (Appendix 2). Review question: Is any evidence available to show that combined ...
  10. 26 May 2014
    Comparing treatment of non-severe pneumonia in children aged 2 to 59 months with and without antibiotics
    Background Pneumonia is an infection of the lungs. In children it is one of the leading causes of childhood deaths across the globe. Pneumonia can be classified based on the World Health Organization (WHO) guidelines. This classification involves assessment of certain clinical signs and symptoms and the severity of disease. The treatment is then tailored ...

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