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  1. 17 Sep 2014
    Acellular vaccines for preventing whooping cough (pertussis) in children Updated
    Review question We aimed to answer the question of whether acellular pertussis vaccines are as effective as the whole-cell vaccines at protecting children against whooping cough (pertussis), but with fewer side effects. Background Whooping cough can be a serious respiratory infection in children and is caused by the bacterium Bordetella pertussis ...
  2. 15 Sep 2014
    Rapid viral testing for children in the Emergency Department with fever and respiratory symptoms Updated
    Review question Does rapid viral testing in the Emergency Department influence the treatment of children with fever and breathing symptoms? Background Otherwise healthy children, aged 0 to 18 years, admitted to Emergency Departments (EDs) with fever and respiratory symptoms represent a major burden to the healthcare system, as well as significant ...
  3. 8 Sep 2014
    Self-management education for cystic fibrosis Updated
    We set out to review the effects of self-management education for cystic fibrosis on a range of health outcomes in individuals of all ages with cystic fibrosis and their caregivers. Our search for available evidence identified four trials, and all four compared a form of self-management education to standard treatment. The precise focus of self management ...
  4. 7 Aug 2014
    What are the effects of vitamins E and C, beta-carotene, selenium and glutathione on lung disease in people with cystic fibrosis? Updated
    Background Frequent chest infections in people with cystic fibrosis cause long-lasting inflammation in their lungs. Cells causing inflammation produce a kind of oxygen molecule (reactive oxygen species (ROS)) which can easily harm proteins and DNA (oxidative damage). To fight these effects, the body may produce antioxidants. The genetic defect in ...
  5. 5 Aug 2014
    Pneumococcal vaccines for children and adults with cystic fibrosis Updated
    Cystic fibrosis is an inherited disease which causes mucus in the lungs to be more sticky than normal, leading to frequent lung infections and lung damage. Pneumococcus is a type of bacteria that can cause infection throughout the body, including in the urine, blood stream, fluid around the brain and in the lungs. These infections can be very serious ...
  6. 31 Jul 2014
    Are inhaled anticholinergics added to β2-agonists beneficial in children hospitalised with acute asthma?
    Background: Anticholinergics (e.g. ipratropium bromide, atropine sulfate) are inhaled drugs. They relax the airway muscles and decrease secretions. Anticholinergics are sometimes used in addition to beta2-agonists (such as salbutamol and terbutaline), which are potent drugs given to relax smooth muscles in the airways in children with acute asthma. ...
  7. 20 Jul 2014
    The use of vibrating devices to help people with cystic fibrosis clear their airways of mucus
    Review question We reviewed the evidence about the effect of vibrating devices (e.g. Flutter, acapella, cornet, Quake®, intrapulmonary percussive ventilation, high frequency chest wall oscillators (e.g. Vest), VibraLung and MetaNeb) to help people with cystic fibrosis clear their airways of mucus. Background People with cystic fibrosis have too ...
  8. 16 Jul 2014
    Do inhaled corticosteroids reduce growth in children with persistent asthma?
    Review question: We reviewed the evidence on whether inhaled corticosteroids (ICS) could affect growth in children with persistent asthma, that is, a more severe asthma that requires regular use of medications for control of symptoms. Background: Treatment guidelines for asthma recommend ICS as first-line therapy for children with persistent asthma. ...
  9. 16 Jul 2014
    Does altering the dose of inhaled corticosteroids make a difference in growth among children with asthma?
    Background Asthma guidelines recommend inhaled corticosteroids (ICS) as the first choice of treatment for children with persistent asthma that is not well controlled when only a reliever inhaler is used to treat symptoms. Steroids work by reducing inflammation in the lungs and are known to control underlying symptoms of asthma. However, parents and ...
  10. 18 Jun 2014
    Psychological treatments to help individuals with cystic fibrosis and their caregivers manage the disease
    Cystic fibrosis is a genetic disorder that damages many of the body's organs and can shorten a person's life span. The disease is progressive, stressful to manage, and needs complex and time-consuming treatments, leaving patients and caregivers stressed due to the challenges of the treatment. Thus, individuals with cystic fibrosis and their family members ...

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