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  1. 5 Aug 2014
    Pneumococcal vaccines for children and adults with cystic fibrosis Updated
    Cystic fibrosis is an inherited disease which causes mucus in the lungs to be more sticky than normal, leading to frequent lung infections and lung damage. Pneumococcus is a type of bacteria that can cause infection throughout the body, including in the urine, blood stream, fluid around the brain and in the lungs. These infections can be very serious ...
  2. 4 Aug 2014
    Treatments applied to the skin for fungal infections of the groin and body New
    Background Up to 20% of the world's population is affected by fungal skin infections of the groin ('jock' itch, or tinea cruris) or of the body (ringworm, or tinea corporis), which generally appear as red and itchy areas on the skin. Many topical (directly applied to the skin) treatments are available. Review question Which topical treatments work ...
  3. 28 Jul 2014
    Are oral antibiotics as effective as a combination of injected and oral antibiotics for kidney infections in children? Updated
    Acute pyelonephritis refers to infection of the kidneys and is the most severe form of urinary tract infection (UTI). Acute pyelonephritis causes high fever, vomiting, stomach pain, irritability and poor feeding in infants. We wanted to find out if oral antibiotics were as effective as combined oral and injected antibiotics to treat children for kidney ...
  4. 26 Jul 2014
    PRO 140 for treatment of people with HIV infection
    PRO 140 (a humanized form of the PA14 antibody, a monoclonal CCR5 antibody) is a laboratory made antibody that blocks the CCR5 receptor on CD4 cells. By blocking CCR5, PRO 140 prevents the HIV virus from infecting healthy cells. PRO 140 may be an effective new treatment drug because it has the potential to address the limitations of currently available ...
  5. 25 Jul 2014
    Should Chinese herbal medicines be used in patients with skin and soft-tissue infections? New
    What are skin and soft-tissue infections? Skin and soft-tissue infections (SSTIs) are common infections of the skin or the tissue beneath the skin. They include impetigo, abscesses, cellulitis, erysipelas, necrotising (flesh-killing) skin infections, infections caused by animal or human bites or by animal contact, and infections after surgery. Most ...
  6. 1 Jul 2014
    Shifting HIV care from doctors to non-doctors to improve access to therapy for people living with HIV
    Background High levels of healthcare worker shortage has limited HIV infected patients access to antiretroviral therapy in lower and middle-income countries. This occurs most where the burden of HIV disease is greatest and where access to trained doctors is limited. We wanted to assess if task shifting of care from doctors to non-doctors provides ...
  7. 30 Jun 2014
    Corticosteroids for treating dengue infection in children and adults Updated
    Dengue is a disease caused by a virus transmitted by mosquitoes, occurring in many resource-limited countries, and children are often most severely affected. Most infected patients will recover with mild symptoms, but a few progress to severe dengue and may die. There is no specific treatment for dengue, but some clinicians provide corticosteroids at ...
  8. 30 Jun 2014
    A single dose of primaquine added to malaria treatment to prevent malaria transmission
    We conducted a review of the effects of adding a single dose (or short course) of primaquine to malaria treatment with the aim of reducing the transmission of malaria. We included 17 randomized controlled trials and one quasi-randomized controlled trial. What is primaquine and how might it reduce transmission Primaquine is an antimalarial drug which ...
  9. 29 Jun 2014
    Zinc supplements for preventing middle ear infections
    Background Middle ear infections are common, especially among young children, usually causing earache and some temporary (occasionally permanent) hearing loss. Zinc is an essential micronutrient, which has a role in the optimal functioning of the immune system and resistance to infection. It must be consumed regularly as it cannot be stored in the ...
  10. 23 Jun 2014
    Post-exposure prophylaxis vaccine to prevent varicella (chickenpox)
    Review question This review assessed how useful the varicella (also known as chickenpox) vaccine is in preventing chickenpox when given to children or adults who have never been immunised or previously had chickenpox, but who receive the vaccine within a short time following exposure to a person infectious with chickenpox. Varicella is a highly contagious ...

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