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  1. 24 Nov 2014
    Over-the-counter (OTC) medications for acute cough in children and adults in community settings Updated
    Review question We undertook a review to determine the effectiveness of over-the-counter cough medicines in reducing cough in children and adults in community settings. We found 29 trials involving 4835 people. Background Acute cough is a common and troublesome symptom in children and adults suffering from acute upper respiratory tract infection ...
  2. 19 Nov 2014
    Surgical removal of the tonsils (tonsillectomy) for chronic or recurrent acute tonsillitis Updated
    Review question This review compared the clinical effectiveness and safety of surgery (removal of the tonsils - tonsillectomy, or adenotonsillectomy - removal of the tonsils and adenoid tissues) against non-surgical management in adults and children with frequent or chronic tonsillitis. Background Surgical removal of the tonsils is a commonly performed ...
  3. 11 Nov 2014
    Garlic for the common cold Updated
    Background Garlic is popularly believed to be useful for the common cold. This belief is based on traditional use and some laboratory evidence that garlic has antibacterial and antiviral properties. On average, adults have two to four common colds per year. Study characteristics The evidence is current to the 7 August 2014. Of the eight studies ...
  4. 27 Oct 2014
    Decongestants, antihistamines and nasal irrigation for acute sinusitis in children
    Review question The goal of this review was to determine whether there is any evidence in the medical literature for or against the use of decongestants, antihistamines and nasal irrigation for acute sinusitis in children. Background Young children experience an average of six to eight colds per year. Out of every 10 children with a cold, one develops ...
  5. 11 Sep 2014
    Tonsillectomy for PFAPA syndrome (a rare cause of recurrent fever, mouth ulcers, sore throat and swollen neck glands)
    Review question This review compared the clinical effectiveness and safety of removing the palatine tonsils (tonsillectomy), with and without removal of the adenoids, against non-surgical management of children with periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. We searched for and included any randomised ...
  6. 1 Jul 2014
    Drugs to prevent hearing loss in children receiving platinum chemotherapy for cancer
    Platinum-based chemotherapy, including cisplatin, carboplatin and/or oxaliplatin, is used in the treatment of different types of childhood cancer. Unfortunately, one of the most important adverse effects of platinum chemotherapy is hearing loss. This can occur not only during treatment but also years after the end of treatment. Although hearing loss ...
  7. 29 Jun 2014
    Zinc supplements for preventing middle ear infections
    Background Middle ear infections are common, especially among young children, usually causing earache and some temporary (occasionally permanent) hearing loss. Zinc is an essential micronutrient, which has a role in the optimal functioning of the immune system and resistance to infection. It must be consumed regularly as it cannot be stored in the ...
  8. 26 Jun 2014
    Different infusion durations for preventing platinum-induced hearing loss in children with cancer
    Platinum-based chemotherapy, including cisplatin, carboplatin or oxaliplatin, or a combination of these, is used to treat different types of childhood cancer. Unfortunately, one of the most important adverse effects of platinum chemotherapy is hearing loss. This can occur not only during treatment but also years after the end of treatment. Although ...
  9. 5 Jun 2014
    Photodynamic therapy for recurrent respiratory papillomatosis
    Background Recurrent respiratory papillomatosis is a condition of the mucosal lining of the upper airway, which leads to multiple benign, wart-like growths (papilloma). Although not cancerous, it can lead to serious problems, including hoarseness and airway obstruction. The main treatment is repeated surgical removal of the papilloma using a laser ...
  10. 2 Apr 2014
    Vaccination against a bacterium called pneumococcus for preventing middle ear infection
    Review question We reviewed the evidence about the effect of vaccination against pneumococcus (a type of bacterium) on preventing middle ear infections in children. Background Middle ear infection, or otitis media, is one of the most common respiratory infections in childhood. Infection with Streptococcus pneumoniae (pneumococcus) is a frequent cause ...

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