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  1. 15 Jan 2015
    Using oxygen at high pressure (in a compression chamber) for the treatment of individuals with severe soft tissue infection (necrotizing fasciitis) New
    Severe soft tissue infection (necrotizing fasciitis) is life threatening, is associated with prolonged hospital stay and carries high risk of long-term loss of function. Routine treatment consists of immediate surgical removal of infected tissue and administration of antibiotics. Use of hyperbaric oxygen therapy, or HBOT, in addition to surgery and ...
  2. 9 Jan 2015
    Ultrasound guidance versus anatomical landmarks for internal jugular vein catheterization New
    People who are critically ill sometimes need a catheter in a central vein to help with diagnosis and treatment. The catheter may be placed in a large vein in the neck (internal jugular vein), upper chest (subclavian vein) or groin (femoral vein). However, this procedure carries risks such as arterial puncture (puncturing an artery instead of the vein ...
  3. 9 Jan 2015
    Ultrasound guidance versus anatomical landmarks for subclavian or femoral vein catheterization New
    People who are critically ill sometimes need a central venous catheter to help with diagnosis and treatment. The catheter may be placed in a large vein in the neck (internal jugular vein), upper chest (subclavian/axillary vein) or groin (femoral vein). However, this procedure carries risks such as arterial puncture and other complications and should ...
  4. 8 Jan 2015
    Etomidate for sedating critically ill people during emergency endotracheal intubation New
    Review question Does a single dose of etomidate increase mortality or complications in people who are critically ill and undergoing emergency endotracheal intubation? Background People who are critically ill often need help breathing. One way to do this is called endotracheal intubation. This involves placing a tube into the windpipe (trachea) and ...
  5. 6 Jan 2015
    Dexmedetomidine and clonidine for long-term sedation during mechanical ventilation in critically ill patients New
    Review question We reviewed the evidence about the safety and efficacy of dexmedetomidine and clonidine (known as alpha-2 agonists) for long-term sedation during mechanical ventilation in critically ill patients in the intensive care unit (ICU). Background Sedation is an important treatment for critically ill patients who need a machine to support ...
  6. 6 Jan 2015
    Protocol-directed sedation to reduce duration of mechanical ventilation New
    Review question We reviewed the evidence to determine if the use of protocol-directed sedation reduced the duration of mechanical ventilation (method to mechanically assist breathing) in critically ill people. Background Determining the sedation needs of critically ill people is an important part of critical care to assist recovery and ensure humane ...
  7. 23 Dec 2014
    Does a local anaesthetic injection in children and young people having dental treatment under general anaesthetic reduce pain after treatment? New
    Review question Do injections of local anaesthetic given whilst children and young people (aged 17 years or younger) are having dental treatment under general anaesthetic reduce the amount of pain felt afterwards? Background It can be difficult when giving dental treatment to children and young people to do it simply using a local anaesthetic (LA) ...
  8. 18 Dec 2014
    Observation alone versus drain tube or needle insertion (interventional) for primary spontaneous pneumothorax in adults without previous lung disease. New
    Review question: A primary spontaneous pneumothorax (PSP) is a collection of air in the lining of the lung that occurs on its own or without a traumatic event. When this occurs, people can have chest pain and shortness of breath. Most of the time, the air in the lung is absorbed by the body and slowly decreases with time. Most of the guidelines in ...
  9. 28 Oct 2014
    Aquatic exercise training for fibromyalgia Podcast
    Research question We reviewed studies on the effects of aquatic exercise training for people with fibromyalgia on wellness, symptoms, fitness, and adverse effects. Background: what is fibromyalgia and what is aquatic training? People with fibromyalgia have persistent, widespread body pain and often experience symptoms such as fatigue, stiffness, ...
  10. 10 Oct 2014
    Intranasal fentanyl for the treatment of children in acute pain
    Background Pain is the most common reason why patients are seen in emergency departments (EDs). The challenging nature of treating children in acute severe pain is reflected in the medical literature by poor pain management in this population. We reviewed evidence on the effect of intranasal fentanyl (INF) (a strong pain relief drug, similar to morphine) ...

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