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  1. 23 Jul 2014
    Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus New
    Review question We reviewed the evidence about the effect of deep anterior lamellar keratoplasty (DALK) (new technique) versus penetrating keratoplasty (standard technique) in people with keratoconus. Background Keratoconus is a disease of the cornea, which is the clear surface at the very front of the eye. In eyes with keratoconus, the cornea becomes ...
  2. 23 Jul 2014
    Bisphosphonate therapy for osteogenesis imperfecta Updated
    Osteogenesis imperfecta is also known as brittle bone disease. It is a genetic condition which can be passed on from a parent to child or occur in the child without any other family history. An affected person is at risk for frequent breaks of the long bones or collapse of the vertebral bones. There is no cure for osteogenesis imperfecta and treatment ...
  3. 23 Jul 2014
    Treatment of amblyopia (lazy eye) caused by strabismus (squint) with patching or optical treatment (glasses or penalisation) or both Updated
    Review question: Treatment of amblyopia (lazy eye) caused by strabismus (squint) with patching or optical treatment (glasses or penalisation) or both. Background: Amblyopia is a common childhood condition which causes a reduction in vision of one or both eyes which is not caused by any eye disease. Amblyopia can be caused by the presence of a squint ...
  4. 23 Jul 2014
    Statins for children with inherited high blood cholesterol Updated
    Familial hypercholesterolemia is an inherited disease in which blood cholesterol level is high. Vascular diseases often occur at an earlier age than usual, especially amongst men. Thus lifelong therapies to reduce blood cholesterol (started in childhood) are needed. In children with familial hypercholesterolemia, diet has been the main treatment option. ...
  5. 20 Jul 2014
    The use of vibrating devices to help people with cystic fibrosis clear their airways of mucus Updated
    Review question We reviewed the evidence about the effect of vibrating devices (e.g. Flutter, acapella, cornet, Quake®, intrapulmonary percussive ventilation, high frequency chest wall oscillators (e.g. Vest), VibraLung and MetaNeb) to help people with cystic fibrosis clear their airways of mucus. Background People with cystic fibrosis have too ...
  6. 18 Jul 2014
    Felbamate as an add-on therapy for refractory epilepsy Updated
    Epilepsy is a chronic and disabling neurologic disorder, affecting approximately 1% of the population. Up to 30% of people with epilepsy have seizures that are resistant to currently available drugs. Felbamate is one of the second-generation antiepileptic drugs and its effects as an add-on therapy to standard drugs are assessed in this review. Only ...
  7. 17 Jul 2014
    Continuous versus intermittent bolus feeding for gastro-oesophageal reflux disease New
    Preterm and low birth weight infants are often unable to be fed orally because they cannot suck and swallow effectively. Therefore, they need to be fed via a tube placed into the stomach (intragastric). Tube feeding can be given by the intermittent bolus method, whereby milk is given over a short time (15 to 30 minutes), or by the continuous feeding ...
  8. 16 Jul 2014
    Phototherapy for treating pressure ulcers New
    What are pressure ulcers? Pressure ulcers (also called bed sores or pressure sores) are sores on the skin caused by constant pressure or friction. They usually affect people who are immobilised or find it difficult to move themselves, for example the elderly or paralysed. Pressure ulcers frequently occur on bony parts of the body, such as the heels ...
  9. 16 Jul 2014
    Do inhaled corticosteroids reduce growth in children with persistent asthma? New
    Review question: We reviewed the evidence on whether inhaled corticosteroids (ICS) could affect growth in children with persistent asthma, that is, a more severe asthma that requires regular use of medications for control of symptoms. Background: Treatment guidelines for asthma recommend ICS as first-line therapy for children with persistent asthma. ...
  10. 16 Jul 2014
    Does altering the dose of inhaled corticosteroids make a difference in growth among children with asthma? New
    Background Asthma guidelines recommend inhaled corticosteroids (ICS) as the first choice of treatment for children with persistent asthma that is not well controlled when only a reliever inhaler is used to treat symptoms. Steroids work by reducing inflammation in the lungs and are known to control underlying symptoms of asthma. However, parents and ...

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