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  1. 24 Oct 2014
    Treatments to cure long-term infections with Burkholderia cepacia in people with cystic fibrosis New
    Review question We reviewed the evidence for antibiotic treatment to cure early infection with Burkholderia cepacia complex in people with cystic fibrosis and prevent it becoming permanent. Background Cystic fibrosis is an inherited disease and people who have this disease produce large amounts of thick mucus which is difficult to clear. This mucus ...
  2. 24 Oct 2014
    Do school tobacco policies prevent uptake of smoking? New
    Background: We reviewed the evidence that School tobacco policies (STPs) might prevent smoking initiation among adolescents, as there may be some evidence that the school environment can influence young people to smoke. STP is intended to regulate whether and where pupils can smoke, adult smoking in school, and penalties for pupils caught smoking. ...
  3. 23 Oct 2014
    Pharmacotherapy for tooth grinding or clenching during the sleep (sleep bruxism) New
    Background There are several signs and symptoms of sleep bruxism, such as abnormal tooth wear, fractured teeth, jaw muscle discomfort, joint pain or tenderness, and headaches. Treatments include odontological devices such as occlusal splints, psychotherapy and medications (pharmacotherapy). Pharmacological treatments include drugs such as benzodiazepines, ...
  4. 19 Oct 2014
    Non-drug management of breathing problems for children with severe physical and intellectual impairment New
    Background For a variety of reasons, some children live with very severe intellectual and physical problems; they are unable to walk or talk and require a lot of care. In this study we refer to them as children with severe global developmental delay (SGDD); this is not a specific diagnosis but is rather an 'umbrella term' used to describe a group of ...
  5. 15 Oct 2014
    Is it better to do strabismus (squint) surgery before or after completing amblyopia (lazy eye) treatment? New
    Background In normal development of vision, children are able to use the visual information from each of their two eyes to form a single image. When an infant or child's eyes are not properly aligned, this is called strabismus (also known as squint). With misalignment, the two eyes do not work together to relay visual information. The brain may suppress ...
  6. 15 Oct 2014
    Blood thinners to prevent blood clots in people with cancer and central venous catheters Updated
    Background A central venous catheter (CVC) is a tube that is inserted into a large vein to give fluids or drugs. CVC placement increases the risk of blood clots in people with cancer. This systematic review evaluated the efficacy and safety of blood thinning agents (anticoagulants) in people with cancer. Study characteristics We searched the scientific ...
  7. 15 Oct 2014
    Non-nutritive sucking for gastro-oesophageal reflux disease in preterm and low birth weight infants New
    Background Gastro-oesophageal reflux is the passage of the contents of the stomach into the oesophagus (feeding tube) with or without vomiting. It is relatively common in preterm infants and can sometimes lead to troublesome complications. Non-nutritive sucking is sucking on a dummy (pacifier) before, during, or after feeding by tube; before or after ...
  8. 14 Oct 2014
    Cannabis for schizophrenia Updated
    Many people with the serious mental illness schizophrenia smoke cannabis but it is not known why people do so or the effects of smoking cannabis. It is unclear what the best methods are that help people to reduce or stop smoking cannabis. Cannabis is the most consumed illicit drug in the world – amounting to 120 to 224 million users. Cannabis, which ...
  9. 13 Oct 2014
    Pancreatic enzyme supplements for people with cystic fibrosis New
    Review question We reviewed the evidence about how good pancreatic enzyme supplements are in overcoming the enzyme deficiency in people with cystic fibrosis and if these supplements have any side effects. Background Between 80% and 90% of people with cystic fibrosis take pancreatic enzyme supplements. In these people, the pancreas is often not able ...
  10. 10 Oct 2014
    Gene therapy for sickle cell disease Updated
    Sickle cell disease results when a child inherits faulty genes for producing haemoglobin from both parents. It is a disease that is linked with frequent illness from early life and often results in death earlier than in the general population. Gene therapy replaces these faulty genes with normal ones. We looked for trials that used this approach of ...

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