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  1. 20 Aug 2014
    Budesonide for maintenance of remission in Crohn's disease Updated
    Budesonide is a corticosteroid drug which is rapidly broken down by the liver, reducing corticosteroid-related side effects (e.g., moon face). Research showing that budesonide is effective in treating active Crohn's disease has led to clinical trials examining the effect of budesonide on reducing disease recurrence in non-active Crohn's disease. This ...
  2. 19 Aug 2014
    Reducing unwanted movement of teeth during treatment with orthodontic braces, comparing surgically placed implants as stabilisers (anchors) with other conventional methods Updated
    Review question This review, produced by the Cochrane Oral Health Group, seeks to assess the effects of using implants surgically placed in bone in the mouth in order to stabilise (anchor) teeth during treatment with orthodontic braces and compares implants with the use of conventional methods. It also assesses the effects of different surgical anchorage ...
  3. 18 Aug 2014
    Glasses to prevent eye misalignment in far-sighted children
    Review question We compared the benefits and harms of wearing glasses to other interventions in far-sighted children to prevent the development of eye misalignment. Background Infants typically are born hyperopic, or far-sighted, and as they grow, their eyes typically grow to where they can see clearly. Some children, however, remain very far-sighted. ...
  4. 14 Aug 2014
    Urate oxidase for the prevention and treatment of complications from massive lysis (breakdown) of tumour cells in children with cancer Updated
    Tumour lysis syndrome occurs when uric acid and other cellular substances are rapidly released into the circulation when tumour cells are broken down spontaneously or during treatment. Uric acid has low solubility (does not dissolve easily); therefore, it can build up in the kidney resulting in kidney failure and possibly death eventually. Urate oxidase ...
  5. 12 Aug 2014
    Interventions for congenital talipes equinovarus (clubfoot) Updated
    Review question The purpose of this review was to assess treatments for congenital talipes equinovarus (clubfoot). Background Clubfoot is a condition, present at birth, in which the foot is in an inturned position. There is no known cause. Different treatments might be effective at different stages: at birth (initial presentation); when initial ...
  6. 8 Aug 2014
    Orthodontic treatment for posterior crossbites Updated
    Review question We conducted this review to assess the effects of different orthodontic treatments for correcting posterior crossbites. Background Posterior crossbite is when the top back teeth bite down inside the bottom back teeth. It occurs when the top teeth or jaw are narrower than the bottom teeth and can happen on one or both sides of the ...
  7. 7 Aug 2014
    What are the effects of vitamins E and C, beta-carotene, selenium and glutathione on lung disease in people with cystic fibrosis? Updated
    Background Frequent chest infections in people with cystic fibrosis cause long-lasting inflammation in their lungs. Cells causing inflammation produce a kind of oxygen molecule (reactive oxygen species (ROS)) which can easily harm proteins and DNA (oxidative damage). To fight these effects, the body may produce antioxidants. The genetic defect in ...
  8. 6 Aug 2014
    Pulp treatment for extensive decay in primary teeth Updated
    Review question The main question addressed by this review is how effective are different options for treating extensive tooth decay in children's milk teeth to resolve the child's symptoms (typically pain, swelling, abnormal movement) and tooth signs (as shown on an x-ray). Background Tooth decay in the milk teeth (or primary teeth) of children ...
  9. 5 Aug 2014
    Pneumococcal vaccines for children and adults with cystic fibrosis Updated
    Cystic fibrosis is an inherited disease which causes mucus in the lungs to be more sticky than normal, leading to frequent lung infections and lung damage. Pneumococcus is a type of bacteria that can cause infection throughout the body, including in the urine, blood stream, fluid around the brain and in the lungs. These infections can be very serious ...
  10. 4 Aug 2014
    Treatments applied to the skin for fungal infections of the groin and body New
    Background Up to 20% of the world's population is affected by fungal skin infections of the groin ('jock' itch, or tinea cruris) or of the body (ringworm, or tinea corporis), which generally appear as red and itchy areas on the skin. Many topical (directly applied to the skin) treatments are available. Review question Which topical treatments work ...

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