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  1. 30 Oct 2014
    Does administering colony-stimulating factors plus antibiotics in people with fever and low white cell count reduce hospitalization? Updated
    Background: People undergoing chemotherapy often experience febrile neutropenia, characterized by a high temperature combined with a low white blood cell count. Febrile neutropenia is a potentially life-threatening condition and requires prompt medical intervention. The standard treatment for febrile neutropenia includes supportive care of fluids, ...
  2. 30 Oct 2014
    Eculizumab for treating patients with paroxysmal nocturnal hemoglobinuria New
    Review question We reviewed the evidence about the effects of eculizumab for treating patients with paroxsymal nocturnal hemoglobinuria. Background Paroxysmal nocturnal hemoglobinuria is a disorder of the hematopoietic stem cells (a cell that can self renew and differentiate into one or more cell types). It is characterized by episodes of intravascular ...
  3. 28 Oct 2014
    Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes (inherited disorders of movement co-ordination) New
    Review question We reviewed the evidence about the effects of treatment on speech difficulties in people with Friedreich ataxia and other hereditary ataxias. Background People with hereditary ataxia develop problems with co-ordinating movement, which becomes worse over time. There are a range of other symptoms but this is the main feature of this ...
  4. 28 Oct 2014
    Aquatic exercise training for fibromyalgia New
    Research question We reviewed studies on the effects of aquatic exercise training for people with fibromyalgia on wellness, symptoms, fitness, and adverse effects. Background: what is fibromyalgia and what is aquatic training? People with fibromyalgia have persistent, widespread body pain and often experience symptoms such as fatigue, stiffness, ...
  5. 27 Oct 2014
    Decongestants, antihistamines and nasal irrigation for acute sinusitis in children Updated
    Review question The goal of this review was to determine whether there is any evidence in the medical literature for or against the use of decongestants, antihistamines and nasal irrigation for acute sinusitis in children. Background Young children experience an average of six to eight colds per year. Out of every 10 children with a cold, one develops ...
  6. 24 Oct 2014
    Do school tobacco policies prevent uptake of smoking? New
    Background: We reviewed the evidence that School tobacco policies (STPs) might prevent smoking initiation among adolescents, as there may be some evidence that the school environment can influence young people to smoke. STP is intended to regulate whether and where pupils can smoke, adult smoking in school, and penalties for pupils caught smoking. ...
  7. 24 Oct 2014
    Treatments to cure long-term infections with Burkholderia cepacia in people with cystic fibrosis New
    Review question We reviewed the evidence for antibiotic treatment to cure early infection with Burkholderia cepacia complex in people with cystic fibrosis and prevent it becoming permanent. Background Cystic fibrosis is an inherited disease and people who have this disease produce large amounts of thick mucus which is difficult to clear. This mucus ...
  8. 23 Oct 2014
    Pharmacotherapy for tooth grinding or clenching during the sleep (sleep bruxism) New
    Background There are several signs and symptoms of sleep bruxism, such as abnormal tooth wear, fractured teeth, jaw muscle discomfort, joint pain or tenderness, and headaches. Treatments include odontological devices such as occlusal splints, psychotherapy and medications (pharmacotherapy). Pharmacological treatments include drugs such as benzodiazepines, ...
  9. 19 Oct 2014
    Non-drug management of breathing problems for children with severe physical and intellectual impairment New
    Background For a variety of reasons, some children live with very severe intellectual and physical problems; they are unable to walk or talk and require a lot of care. In this study we refer to them as children with severe global developmental delay (SGDD); this is not a specific diagnosis but is rather an 'umbrella term' used to describe a group of ...
  10. 15 Oct 2014
    Is it better to do strabismus (squint) surgery before or after completing amblyopia (lazy eye) treatment? New
    Background In normal development of vision, children are able to use the visual information from each of their two eyes to form a single image. When an infant or child's eyes are not properly aligned, this is called strabismus (also known as squint). With misalignment, the two eyes do not work together to relay visual information. The brain may suppress ...

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