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  1. 28 Jul 2014
    Are oral antibiotics as effective as a combination of injected and oral antibiotics for kidney infections in children? Updated
    Acute pyelonephritis refers to infection of the kidneys and is the most severe form of urinary tract infection (UTI). Acute pyelonephritis causes high fever, vomiting, stomach pain, irritability and poor feeding in infants. We wanted to find out if oral antibiotics were as effective as combined oral and injected antibiotics to treat children for kidney ...
  2. 26 Jul 2014
    PRO 140 for treatment of people with HIV infection
    PRO 140 (a humanized form of the PA14 antibody, a monoclonal CCR5 antibody) is a laboratory made antibody that blocks the CCR5 receptor on CD4 cells. By blocking CCR5, PRO 140 prevents the HIV virus from infecting healthy cells. PRO 140 may be an effective new treatment drug because it has the potential to address the limitations of currently available ...
  3. 26 Jul 2014
    A comparison of the effectiveness and safety of the two most common therapies for people with multiple sclerosis (MS) New
    Background At present no clear evidence is available on the equivalence of therapeutic agents used in people with MS. This study is important because it is the first report evaluating whether two treatments, interferons (IFNs)-beta and glatiramer acetate (GA), have the same effect on the disease course. Study characteristics We searched medical databases ...
  4. 25 Jul 2014
    Should Chinese herbal medicines be used in patients with skin and soft-tissue infections? New
    What are skin and soft-tissue infections? Skin and soft-tissue infections (SSTIs) are common infections of the skin or the tissue beneath the skin. They include impetigo, abscesses, cellulitis, erysipelas, necrotising (flesh-killing) skin infections, infections caused by animal or human bites or by animal contact, and infections after surgery. Most ...
  5. 23 Jul 2014
    Treatment of amblyopia (lazy eye) caused by strabismus (squint) with patching or optical treatment (glasses or penalisation) or both Updated
    Review question: Treatment of amblyopia (lazy eye) caused by strabismus (squint) with patching or optical treatment (glasses or penalisation) or both. Background: Amblyopia is a common childhood condition which causes a reduction in vision of one or both eyes which is not caused by any eye disease. Amblyopia can be caused by the presence of a squint ...
  6. 23 Jul 2014
    Statins for children with inherited high blood cholesterol Updated
    Familial hypercholesterolemia is an inherited disease in which blood cholesterol level is high. Vascular diseases often occur at an earlier age than usual, especially amongst men. Thus lifelong therapies to reduce blood cholesterol (started in childhood) are needed. In children with familial hypercholesterolemia, diet has been the main treatment option. ...
  7. 23 Jul 2014
    Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus New
    Review question We reviewed the evidence about the effect of deep anterior lamellar keratoplasty (DALK) (new technique) versus penetrating keratoplasty (standard technique) in people with keratoconus. Background Keratoconus is a disease of the cornea, which is the clear surface at the very front of the eye. In eyes with keratoconus, the cornea becomes ...
  8. 23 Jul 2014
    Bisphosphonate therapy for osteogenesis imperfecta
    Osteogenesis imperfecta is also known as brittle bone disease. It is a genetic condition which can be passed on from a parent to child or occur in the child without any other family history. An affected person is at risk for frequent breaks of the long bones or collapse of the vertebral bones. There is no cure for osteogenesis imperfecta and treatment ...
  9. 20 Jul 2014
    The use of vibrating devices to help people with cystic fibrosis clear their airways of mucus Updated
    Review question We reviewed the evidence about the effect of vibrating devices (e.g. Flutter, acapella, cornet, Quake®, intrapulmonary percussive ventilation, high frequency chest wall oscillators (e.g. Vest), VibraLung and MetaNeb) to help people with cystic fibrosis clear their airways of mucus. Background People with cystic fibrosis have too ...
  10. 18 Jul 2014
    Felbamate as an add-on therapy for refractory epilepsy Updated
    Epilepsy is a chronic and disabling neurologic disorder, affecting approximately 1% of the population. Up to 30% of people with epilepsy have seizures that are resistant to currently available drugs. Felbamate is one of the second-generation antiepileptic drugs and its effects as an add-on therapy to standard drugs are assessed in this review. Only ...

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