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  1. 25 Sep 2014
    Interventions for the management of oral ulcers in Behçet's disease New
    Review question This review has been conducted to assess the effects of different interventions, administered systemically or topically, for the prevention or treatment of oral ulcers in people with Behçet's disease. The interventions could be compared with an alternative intervention, no intervention or the administration of a placebo. Background ...
  2. 23 Sep 2014
    Orthodontic and orthopaedic treatment for anterior open bite in children Updated
    Interventions were able to correct anterior open bite but this was based on data from two studies that have problems in their quality.Open bite is characterised by a lack of vertical overlap of the upper and lower incisors. This problem has several possible causes such as mouth breathing, sucking habits, alteration of development of jaw and maxilla. ...
  3. 23 Sep 2014
    Centre-based day care for children younger than five years of age in high-income countries New
    Review question This review evaluated the effects of centre-based day care on the cognitive and psychosocial development of children younger than five years of age and the economic situation of their parents in high-income countries (as defined by the World Bank 2011). We defined 'centre-based day care' as supervision of children in a publicly accessible ...
  4. 22 Sep 2014
    Clinical pathways for chronic cough in children Updated
    Background Clinical pathways serve as a tool or algorithm (like a flow chart) that can be used in the treatment of patients with various chronic diseases. They provide a clear guide that assists doctors in diagnosing an illness and in making decisions with the patient about what treatment is needed or which specialists should be seen or tests ordered ...
  5. 22 Sep 2014
    Treatment of the cough in whooping cough Updated
    Review question We reviewed the evidence from 12 studies about the effect of treatments for cough in patients with whooping cough. Background We wanted to discover whether any medicines are effective at treating cough in patients with whooping cough (also known as pertussis). These medicines included pertussis immunoglobulin (antibodies to increase ...
  6. 19 Sep 2014
    Intracystic bleomycin for children with cystic craniopharyngiomas Updated
    Craniopharyngiomas are rare, slow-growing, benign tumours in the hypothalamic-pituitary region of the brain. Although they are benign, i.e. the tumour lacks the ability to invade neighboring tissue or metastasise, there is considerable morbidity and disability even when the tumour can be resected completely. Cystic craniopharyngiomas are the commonest ...
  7. 19 Sep 2014
    Intravenous immunoglobulin for Guillain-Barré syndrome Updated
    Review question Intravenous immunoglobulin (IVIg) is a treatment in which antibodies from donated blood are injected into a person's vein. We wanted to find out whether IVIg can speed up recovery from Guillain-Barré syndrome (GBS). Background GBS is an uncommon disease of the nerves outside the brain and spinal cord. It causes weakness, numbness ...
  8. 19 Sep 2014
    Codeine, alone and with paracetamol (acetaminophen), for cancer pain New
    Codeine is an opioid medication commonly used worldwide to treat pain including cancer pain. Oral codeine, either alone or in combination with paracetamol, provided good pain relief for some people with cancer pain, based on limited amounts of information. In this review we set out to estimate how well codeine worked, how many people had side effects, ...
  9. 19 Sep 2014
    Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents New
    Background ADHD affects a large number of children and adolescents, giving rise to problems with inattention, hyperactivity, and impulsivity. A variety of medications, including tricyclic antidepressants (TCAs), may be used to treat the core symptoms of ADHD. Review question We reviewed the evidence about the effectiveness of TCAs in improving the ...
  10. 17 Sep 2014
    Acellular vaccines for preventing whooping cough (pertussis) in children
    Review question We aimed to answer the question of whether acellular pertussis vaccines are as effective as the whole-cell vaccines at protecting children against whooping cough (pertussis), but with fewer side effects. Background Whooping cough can be a serious respiratory infection in children and is caused by the bacterium Bordetella pertussis ...

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