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  1. 10 Dec 2013
    Drugs for cancer-related fatigue
    Fatigue associated with cancer is a significant problem. It can occur because of side effects of treatment or because of the disease itself. It can have a significant impact on a person's ability to function. The causes of fatigue are not fully understood and so it is very difficult to treat appropriately. This review has examined drug treatment for ...
  2. 21 Oct 2013
    Opioids for the management of breakthrough pain in cancer patients
    Background Oral and nasal transmucosal fentanyl citrate are effective in the management of breakthrough pain. Breakthrough pain is an additional sudden brief pain that occurs despite taking regularly scheduled doses of pain medication. It is a common and debilitating component of pain in patients with cancer. Study characteristics We sought clinical ...
  3. 5 Oct 2013
    Transdermal fentanyl for cancer pain
    Fentanyl patches placed on the skin produced good pain relief for most people with moderate or severe cancer pain. One person in two or three who gets cancer will suffer from pain that becomes moderate or severe in intensity. The pain tends to get worse as the cancer progresses. Morphine taken by mouth has been used since the 1950s for controlling cancer ...
  4. 11 Sep 2013
    Prevention of thrombosis in children with cancer and tunnelled CVCs
    Children with cancer are at higher risk of thrombosis than children without cancer. This is a result of the disease itself but also of the cancer treatment and the presence of a central venous catheter. In this review, we investigated whether systemic treatments can prevent thrombosis. We identified six studies; two studies investigated low molecular ...
  5. 2 Sep 2013
    Cervico-thoracic or lumbar sympathectomy for neuropathic pain
    Chronic pain due to damaged nerves is called neuropathic pain and is common. Some people consider that certain types of neuropathic pain (reflex sympathetic dystrophy and causalgia, now known collectively as Complex Regional Pain Syndrome (CRPS)) are caused by the sympathetic nervous system. Sympathectomy is a destructive procedure that interrupts the ...
  6. 29 Aug 2013
    Celiac plexus block (CPB) in patients with unresectable pancreatic cancer-related pain
    Abdominal pain is a major symptom in patients with inoperable pancreatic cancer and is often difficult to treat. Celiac plexus block (CPB) is a safe and effective method for reducing this pain. It involves the chemical destruction of the nerve fibres that convey pain from the abdomen to the brain. We searched for studies comparing CPB with standard ...
  7. 23 Jul 2013
    Oral morphine for cancer pain
    Morphine taken by mouth produced good pain relief for most people with moderate or severe cancer pain. One person in two or three who gets cancer will suffer from pain that becomes moderate or severe in intensity. The pain tends to get worse as the cancer progresses. Morphine taken by mouth has been used since the 1950s for controlling cancer pain. ...
  8. 17 Jun 2013
    Using Methadone (an opioid drug) in relieving cancer pain.
    Pain is a common and debilitating symptom of cancer. Methadone is an opioid drug used to treat cancer pain, and can be given by mouth as liquid, tablet or capsule, via the rectum as a suppository, or injected into the vein, muscle or under the skin. This updated review examines clinical trial evidence published up to September 2006 to determine how ...
  9. 9 Jun 2013
    Pharmacological interventions for pruritus in adult palliative care patients
    Pruritus is the medical name for itching, which can be a problem in palliative care settings where treatments for cancer or severe kidney disease are being given. In this review we looked for high quality clinical trials of drug therapies to prevent or treat itching in palliative care. We found that 30 different drugs had been tested in 40 studies, ...
  10. 31 May 2013
    Levomepromazine for the treatment of nausea and vomiting in people with advanced disease
    Nausea and vomiting are common and very unpleasant symptoms that are often experienced by people receiving palliative care. There are several different drug therapies which are available to treat these symptoms. Levomepromazine was originally used to treat schizophrenia but is also used to control nausea and vomiting. It can be given orally or as an ...

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