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  1. 26 Nov 2014
    Is exercise effective for patients with cancer cachexia? New
    Many cancer patients lose weight (body muscle and fat) as part of a cachexia syndrome, which can be caused by the cancer and its treatment. This can result in muscle weakness, fatigue, lack of energy and a reduced quality of life. Exercise is one possible treatment for cancer cachexia and may help reduce the effect it has on patients. In this systematic ...
  2. 17 Nov 2014
    Cetuximab: a new treatment for advanced non-small cell lung cancer New
    Lung cancer is the most common cancer in the world. Advanced non-small cell lung cancer (NSCLC) accounts for about 60% of all lung cancer cases. Since the effectiveness of current standard treatment for advanced NSCLC (i.e. chemotherapy) has reached a ceiling, there is a continuous need for new, more effective treatments to further improve the outcome ...
  3. 13 Nov 2014
    PET-CT scanning to assess the spread of non-small cell lung cancer within the chest New
    In the absence of distant metastasis, treatment options for non-small cell lung cancer depend on how much the disease has spread to the different lymph nodes within the chest, that is, the stage of the disease. If the cancer has not spread beyond the nearest (N1) lymph nodes, surgery is often the treatment of choice. Other treatment options for these ...
  4. 11 Nov 2014
    The role of aerobic physical exercise for adults with haematological malignancies New
    Review question We reviewed the existing evidence regarding the effect of aerobic physical exercise plus standard care compared to standard care alone in adults with haematological malignancies. We found nine randomised controlled trials. Background A haematological malignancy is a tumour of the myeloid or lymphatic cells. Lymphomas, leukaemias, ...
  5. 11 Nov 2014
    Comparison of the stomach-preserving 'Whipple' operation with the classic 'Whipple' operation for patients with cancer of the pancreas or the periampullary region (the point at which the ducts from the liver and pancreas enter the small intestine)
    Pancreatic cancer is a leading cause of cancer death. Two surgical procedures can lead to a cure: the classic Whipple operation, in which part of the pancreas, the gallbladder, the duodenum, the pylorus (outlet of the stomach) and the distal (lower) part of the stomach are removed, and the so-called pylorus-preserving pancreaticoduodenectomy, or pylorus-preserving ...
  6. 7 Nov 2014
    Anaesthetic techniques for risk of malignant tumour recurrence New
    Background Surgery remains a mainstay of treatment for patients with many types of cancer. However, surgical stress and certain anaesthesia and pain medications commonly given during anaesthesia for cancer surgery are known to suppress body defences. Therefore, surgery and anaesthesia might contribute to long-term cancer recurrence. Different types ...
  7. 30 Oct 2014
    Does administering colony-stimulating factors plus antibiotics in people with fever and low white cell count reduce hospitalization? Updated
    Background: People undergoing chemotherapy often experience febrile neutropenia, characterized by a high temperature combined with a low white blood cell count. Febrile neutropenia is a potentially life-threatening condition and requires prompt medical intervention. The standard treatment for febrile neutropenia includes supportive care of fluids, ...
  8. 28 Oct 2014
    Deferasirox for managing iron overload in people with myelodysplastic syndrome Updated
    Review question We aimed to review the evidence about the effects of deferasirox (an oral therapeutic option) on reducing iron overload in people with myelodysplastic syndrome (MDS), which is a diverse group of haematopoietic stem cell disorders. Background Repeated red blood cell transfusions can lead to clinically relevant secondary (i.e. due ...
  9. 15 Oct 2014
    Blood thinners to prevent blood clots in people with cancer and central venous catheters Updated
    Background A central venous catheter (CVC) is a tube that is inserted into a large vein to give fluids or drugs. CVC placement increases the risk of blood clots in people with cancer. This systematic review evaluated the efficacy and safety of blood thinning agents (anticoagulants) in people with cancer. Study characteristics We searched the scientific ...
  10. 9 Oct 2014
    High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer Updated
    Background Radiotherapy has been successfully used to treat cervical cancer for nearly a century as cervical tissue is very sensitive to radiation. Improved survival and local control rates of the disease have made the combination of external beam radiotherapy (EBRT) and intracavity brachytherapy (ICBT) the standard treatment for locally advanced ...

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