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  1. 14 Aug 2014
    Urate oxidase for the prevention and treatment of complications from massive lysis (breakdown) of tumour cells in children with cancer Updated
    Tumour lysis syndrome occurs when uric acid and other cellular substances are rapidly released into the circulation when tumour cells are broken down spontaneously or during treatment. Uric acid has low solubility (does not dissolve easily); therefore, it can build up in the kidney resulting in kidney failure and possibly death eventually. Urate oxidase ...
  2. 25 Jul 2014
    Mycophenolate mofetil versus methotrexate for prevention of graft-versus-host disease following allogeneic hematopoietic stem cell transplantation New
    Background Allogeneic hematopoietic stem cell transplantation is a procedure in which a portion of a healthy donor's stem cells (cells that can develop into various types of blood cells) or bone marrow is obtained and prepared for intravenous infusion. Hematopoietic stem cells are taken from a healthy donor and transplanted into the patient (recipient). ...
  3. 8 Jul 2014
    Blood thinners for the long-term treatment of blood clots in patients with cancer Updated
    Background Patients with cancer are at an increased risk of developing blood clots and might respond differently to blood thinners (anticoagulants) compared with patients without cancer. Study characteristics We searched scientific databases for clinical trials looking at the effects of long-term treatment with different blood thinners on blood ...
  4. 1 Jul 2014
    Oral blood thinners in patients with cancer Updated
    Background This review assessed the effects of oral anticoagulation (blood-thinning drugs) in people with cancer on survival, thromboembolic events, and bleeding outcomes. Study characteristics We searched the scientific literature for studies of anticoagulants in people with cancer. The evidence is current to February 2013. Key results We found ...
  5. 1 Jul 2014
    Drugs to prevent hearing loss in children receiving platinum chemotherapy for cancer Updated
    Platinum-based chemotherapy, including cisplatin, carboplatin and/or oxaliplatin, is used in the treatment of different types of childhood cancer. Unfortunately, one of the most important adverse effects of platinum chemotherapy is hearing loss. This can occur not only during treatment but also years after the end of treatment. Although hearing loss ...
  6. 30 Jun 2014
    Androgen suppression monotherapy for treatment of advanced prostate cancer
    Review question We reviewed the evidence on the effects of androgen suppression monotherapies (non-steroidal antiandrogens compared with medical or surgical castration monotherapy) in men with advanced prostate cancer. Background Prostate cancer is among the top six most lethal cancers, and treatment implies a high disease burden for patients. An ...
  7. 27 Jun 2014
    Can tests used to identify the main groin lymph node/s in women with vulval cancer accurately predict whether the cancer has spread to the groin/s?
    The issue Women with vulval cancer that has spread to the groin lymph nodes need additional treatment. The standard treatment usually involves surgical removal of as many groin nodes as possible (known as complete inguinofemoral lymphadenectomy (IFL)). However, only about 30% of women with vulval cancer in whom lymph nodes are not obviously ...
  8. 26 Jun 2014
    Blood thinners for the prevention of clots in patients with cancer undergoing surgery
    Background Patients with cancer undergoing surgical procedures are at an increased risk of blood clots. The blood thinner administered to prevent these clots can be either an unfractionated heparin (UFH) or low molecular weight heparin (LMWH). These two blood thinners may have different effectiveness and safety profiles. Study characteristics We ...
  9. 26 Jun 2014
    Different infusion durations for preventing platinum-induced hearing loss in children with cancer
    Platinum-based chemotherapy, including cisplatin, carboplatin or oxaliplatin, or a combination of these, is used to treat different types of childhood cancer. Unfortunately, one of the most important adverse effects of platinum chemotherapy is hearing loss. This can occur not only during treatment but also years after the end of treatment. Although ...
  10. 23 Jun 2014
    Vitamin D supplementation for prevention of cancer in adults 
    Review question Does vitamin D supplementation prevent cancer? Background The available evidence on vitamin D and cancer occurrence is intriguing but inconclusive. Many observational studies as well as randomised trials suggest that high vitamin D levels in the blood are related to reduced cancer occurrence. However, results of randomised trials ...

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