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  1. 15 Apr 2014
    Keyhole laparoscopic or open surgery for rectal cancer Updated
    Colorectal (large bowel) cancer including rectal cancer is the third most common cause of cancer deaths in the western world. The risk of developing rectal cancer increases with age and is most common in people around 70 years of age. The treatment consists of complete surgical resection of the tumour and surrounding tissue by a technique called total ...
  2. 9 Apr 2014
    The treatment of cervical pre-cancer (CIN) with anti-inflammatory agents to induce regression and prevent the progression to cervical cancer New
    Review Questions We reviewed the evidence about the effect of non-steroidal anti-inflammatory agents (NSAIDs) to cause regression and prevent the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer. We found only two small studies. Background Cervical pre-cancer (cervical intraepithelial neoplasia: CIN) can progress to invasive ...
  3. 30 Mar 2014
    Selenium for preventing cancer Podcast Updated
    Review question We reviewed the evidence suggesting that selenium can help to prevent cancer. This review updates the first Cochrane review on this topic (Dennert 2011). Background Selenium is a naturally occurring element found in crops, animal products and water. Small amounts of selenium are needed for proper human nutrition. Starting in the ...
  4. 9 Mar 2014
    Antibiotics to prevent surgical site infection after breast cancer surgery Updated
    Breast cancer accounts for one in 10 of all new cancer cases diagnosed and surgical removal of the breast is a common treatment approach. An infection of the surgical wound is often a complication of surgery and taking antibiotics just before the operation significantly reduces the chances of developing an infection. The review is not able to establish ...
  5. 4 Mar 2014
    Comparison of surgical procedures for women diagnosed with precancerous changes of the vulva (high-grade vulval intraepithelial neoplasia)
    Background Vulval intraepithelial neoplasia (VIN) is regarded as a precancerous condition of the skin of the vulva that may further develop into vulval cancer. The condition is usually treated by surgery. The various surgical techniques currently available are either ablative (where the lesion is removed by destruction of tissue using an energy source) ...
  6. 1 Mar 2014
    The benefits and side effects of adding upfront whole brain radiotherapy to surgery or radiosurgery for treatment of brain metastases
    Background For certain patients with a single brain metastasis, surgery to remove the single brain metastasis may be undertaken.  For certain patients with small brain metastatic disease, a highly focused single radiation treatment called radiosurgery, may be used.  It is unclear the benefits and side effects of adding upfront (i.e. a therapy given ...
  7. 27 Feb 2014
    Surgical removal of part of the pancreas and other tissues versus other treatments for patients with pancreatic cancer which invades the surrounding structures
    Background The pancreas is an organ in the abdomen which secretes digestive juices for the digestion of food. It also harbours the insulin secreting cells which maintain the blood sugar levels. Pancreatic cancer is an aggressive cancer. Surgery to remove the cancer improves survival. However, a third of patients with pancreatic cancer have locally ...
  8. 25 Feb 2014
    Extracorporeal photopheresis for acute graft-versus-host disease after haematopoietic stem cell transplantation in paediatric patients
    Background Acute graft-versus-host disease is a common complication after haematopoietic stem cell transplantation (HSCT; transplant of blood-forming stem cells). Immune cells (white blood cells) from the donor recognise the patient's cells as foreign ('non-self'). Therefore, the transplanted immune cells attack the cells of the patient. The main ...
  9. 25 Feb 2014
    Extracorporeal photopheresis treatment for chronic graft-versus-host disease after haematopoietic stem cell transplantation in paediatric patients
    Background Chronic graft-versus-host disease is a common complication after haematopoietic stem cell transplantation (HSCT; transplant of blood-forming stem cells). Immune cells (white blood cells) from the donor recognise the patient's cells as foreign ("non-self"). Therefore, the transplanted immune cells attack the cells of the patient. The main ...
  10. 24 Feb 2014
    Is voriconazole better than amphotericin B or fluconazole to prevent and treat fungal infections in cancer patients with poor immune defence systems
    Background Patients with cancer who are treated with chemotherapy or receive a bone marrow transplant have an increased risk of fungal infections. Such infections can be life-threatening. Antifungal drugs are therefore often given to prevent fungal infections in such patients, either when these patients are known to have a fungal infection or when ...

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