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  1. 28 Jan 2015
    No evidence that cooling patients undergoing brain surgery helps to either reduce death and severe disability or increase harm Updated
    Brain surgery is often required in patients who have abnormal brain blood vessels, had a stroke, sustained a traumatic injury or have suffered spontaneous bleeding into the brain. While surgery can be lifesaving it can also cause further damage due to an associated interruption and reduction of blood flow to the brain cells. Without an adequate supply ...
  2. 22 Jan 2015
    Extracorporeal (external to the body) membrane oxygenation (ECMO) for critically ill adults New
    Review question: Effect of ECMO on survival in critically ill adults. Background: Extracorporeal membrane oxygenation is a form of life support that targets the heart and lungs. For patients with severe lung failure, ECMO provides extracorporeal gas exchange. For those with severe heart failure or cardiac arrest, ECMO (extracorporeal cardiopulmonary ...
  3. 22 Jan 2015
    Zonisamide for neuropathic pain in adults New
    Neuropathic pain can arise from damage to nerves and injury to the central nervous system. It is different from pain messages carried along healthy nerves from damaged tissue (a fall, or cut, or arthritic knee). Neuropathic pain is treated by different medicines than those used for pain from damaged tissue. Medicines like paracetamol or ibuprofen are ...
  4. 15 Jan 2015
    Using oxygen at high pressure (in a compression chamber) for the treatment of individuals with severe soft tissue infection (necrotizing fasciitis) New
    Severe soft tissue infection (necrotizing fasciitis) is life threatening, is associated with prolonged hospital stay and carries high risk of long-term loss of function. Routine treatment consists of immediate surgical removal of infected tissue and administration of antibiotics. Use of hyperbaric oxygen therapy, or HBOT, in addition to surgery and ...
  5. 14 Jan 2015
    Different methods of ventilation (controlling pressure vs volume) for people with acute respiratory failure due to lung injury New
    Review question We reviewed available evidence for the safety and efficacy of controlling pressure versus controlling volume of air delivered during mechanical ventilation in critically ill adults with acute respiratory failure due to lung injury. We found three relevant studies. Background Acute respiratory failure due to acute lung injury (ALI) ...
  6. 12 Jan 2015
    Timing of tracheostomy for critically ill patients who are predicted to be on long-term artificial respiration Updated
    Review question: We reviewed available evidence on the effects of early tracheostomy (≤ 10 days after tracheal intubation) as compared with late tracheostomy (> 10 days after tracheal intubation) in terms of mortality in critically ill patients who predicted to be on long-term artificial respiration. Background: Tracheostomy is a surgical procedure ...
  7. 9 Jan 2015
    Ultrasound guidance versus anatomical landmarks for internal jugular vein catheterization New
    People who are critically ill sometimes need a catheter in a central vein to help with diagnosis and treatment. The catheter may be placed in a large vein in the neck (internal jugular vein), upper chest (subclavian vein) or groin (femoral vein). However, this procedure carries risks such as arterial puncture (puncturing an artery instead of the vein ...
  8. 9 Jan 2015
    Ultrasound guidance versus anatomical landmarks for subclavian or femoral vein catheterization New
    People who are critically ill sometimes need a central venous catheter to help with diagnosis and treatment. The catheter may be placed in a large vein in the neck (internal jugular vein), upper chest (subclavian/axillary vein) or groin (femoral vein). However, this procedure carries risks such as arterial puncture and other complications and should ...
  9. 8 Jan 2015
    Etomidate for sedating critically ill people during emergency endotracheal intubation New
    Review question Does a single dose of etomidate increase mortality or complications in people who are critically ill and undergoing emergency endotracheal intubation? Background People who are critically ill often need help breathing. One way to do this is called endotracheal intubation. This involves placing a tube into the windpipe (trachea) and ...
  10. 8 Jan 2015
    Nortriptyline for neuropathic pain in adults
    Neuropathic pain is pain coming from damaged nerves. It is different from pain messages that are carried along healthy nerves from damaged tissue (for example, a fall, or cut, or arthritic knee). Neuropathic pain is treated by different medicines to those used for pain from damaged tissue. Medicines such as paracetamol or ibuprofen are not usually effective ...

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