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  1. 25 Jul 2014
    Botulinum toxin injectable drug for myofascial pain syndrome (a painful condition that could affect any muscle in the body) in adults
    Myofascial pain syndrome (MPS) is a regional muscular pain syndrome characterised by the presence of trigger points (painful points) in one or more muscles. The pain can be at the trigger point site or it can be felt away from that point when the muscle is pressed, which is called referred pain. Botulinum toxin is a potent chemical that blocks the communication ...
  2. 24 Jul 2014
    Topical lidocaine for neuropathic pain in adults New
    Neuropathic pain is pain coming from damaged nerves. It differs from pain messages carried along healthy nerves from damaged tissue (a fall, or cut, or arthritic knee). Neuropathic pain is treated by different medicines than pain from damaged tissue. Medicines like paracetamol or ibuprofen are usually not effective in neuropathic pain, while medicines ...
  3. 17 Jul 2014
    Air versus saline in the loss of resistance technique for identification of the epidural space New
    Review question Which technique, air or saline, is more efficacious and safe in reducing complications during the loss of resistance technique (sudden loss of pressure on the plunger of the syringe, making the plunger slide smoothly) for identification of the epidural space, and what guidance can be provided to clinicians in their clinical practice? ...
  4. 16 Jul 2014
    Mannitol versus hypertonic saline for intraoperative brain relaxation in patients undergoing surgery for brain tumour New
    Review question: We reviewed evidence on the effectiveness of mannitol and hypertonic saline for brain relaxation in people having surgery (craniotomy) for brain tumour. Background: People with brain tumour undergo a craniotomy, or opening of the skull bone, for its removal. A relaxed brain allows the surgeon to remove the skull bone easily and to ...
  5. 16 Jul 2014
    Physician anaesthetists versus nurse anaesthetists for surgical patients New
    Background There is an increasing demand for surgery, pressure on healthcare providers to reduce costs, and a predicted shortfall in the number of medically qualified anaesthetists. This review aimed to consider whether anaesthesia can be provided equally effectively and safely by nurse anaesthetists (without medical qualifications) as by medically ...
  6. 9 Jul 2014
    Does daily sedation interruption reduce the time critically ill adults spend on breathing machines compared to other sedation strategies? New
    Background: critically ill patients require life-support technologies such as mechanical ventilation (breathing machines) and can experience pain, anxiety, and sleep deprivation related to their illness. Good pain control and adequate sedation are important but too much sedative drug can increase the time on breathing machines and the chance of harmful ...
  7. 7 Jul 2014
    Levetiracetam for neuropathic pain in adults New
    Neuropathic pain can arise from damage to nerves and injury to the central nervous system. It is different from pain messages carried along healthy nerves from damaged tissue (a fall, or cut, or arthritic knee). Neuropathic pain is treated by different medicines than pain from damaged tissue. Medicines like paracetamol or ibuprofen are not usually effective ...
  8. 3 Jul 2014
    Inhaled nitric oxide to treat high blood pressure of the pulmonary vessels after surgery in infants and children with congenital heart disease Updated
    Review question We reviewed the evidence on the effectiveness of inhaled nitric oxide for treatment of high blood pressure in the pulmonary vessels in infants and children born with heart disease. Background Pulmonary hypertension (PH) is an increase in blood pressure in the pulmonary vessels that affects various patient populations and can cause ...
  9. 30 Jun 2014
    Laryngeal mask airway versus endotracheal tube for percutaneous dilatational tracheostomy in critically ill adult patients New
    Critically ill adult patients in intensive care units (ICUs) often require mechanical respiration. Initially, patients are ventilated using an endotracheal tube (ETT). However, patients receiving long-term ventilation often also require a tracheostomy. This procedure involves creating an opening in the neck and trachea, making it possible to circumvent ...
  10. 23 Jun 2014
    Oxycodone for neuropathic pain and fibromyalgia in adults
    Neuropathic pain is pain coming from damaged nerves. It differs from pain messages carried along healthy nerves from damaged tissue (as in a fall, a cut, or an arthritic knee). Neuropathic pain is treated by different medicines than pain from damaged tissue. Medicines such as paracetamol and ibuprofen are not effective in neuropathic pain, while medicines ...

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