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  1. 21 Aug 2014
    Antioxidants to reduce pain in chronic pancreatitis New
    Chronic pancreatitis is a persistent inflammation of the pancreas that in the long run can cause irreparable damage. The major causes of chronic pancreatitis are genetics, alcohol toxicity and other conditions that might damage or obstruct the pancreas. This inflammation can cause pain that often is severe and leaves patients socially isolated and unable ...
  2. 14 Aug 2014
    Does giving patients carbohydrate supplements before planned surgery lead to improved recovery?
    Review question We reviewed the evidence on effects of carbohydrate supplements on the recovery of people undergoing planned surgical procedures. We found 27 studies investigating this question. Background Carbohydrate (sugar-containing) nutritional supplements have become a routine part of the package of care for people undergoing planned surgical ...
  3. 1 Aug 2014
    Is continuous positive airway pressure (CPAP) during the postoperative period useful? New
    Review question Does continuous positive airway pressure during the postoperative period help reduce death and major lung complications after major abdominal surgery? Background General anaesthesia can lead to reduced lung volumes and collapse of the alveoli as well as to reversible, patchy collapse of areas of lung (atelectasis) and subsequent ...
  4. 31 Jul 2014
    Does the administration of nalbuphine provide effective and safe postoperative pain treatment in children? New
    Postoperative pain is still a major problem following surgery in children. There is currently clear evidence that multimodal postoperative pain treatment is the best choice. This approach may involve using nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids. However, due to the fear of side effects such as respiratory depression (where the lungs ...
  5. 25 Jul 2014
    Botulinum toxin injectable drug for myofascial pain syndrome (a painful condition that could affect any muscle in the body) in adults
    Myofascial pain syndrome (MPS) is a regional muscular pain syndrome characterised by the presence of trigger points (painful points) in one or more muscles. The pain can be at the trigger point site or it can be felt away from that point when the muscle is pressed, which is called referred pain. Botulinum toxin is a potent chemical that blocks the communication ...
  6. 24 Jul 2014
    Topical lidocaine for neuropathic pain in adults New
    Neuropathic pain is pain coming from damaged nerves. It differs from pain messages carried along healthy nerves from damaged tissue (a fall, or cut, or arthritic knee). Neuropathic pain is treated by different medicines than pain from damaged tissue. Medicines like paracetamol or ibuprofen are usually not effective in neuropathic pain, while medicines ...
  7. 17 Jul 2014
    Air versus saline in the loss of resistance technique for identification of the epidural space New
    Review question Which technique, air or saline, is more efficacious and safe in reducing complications during the loss of resistance technique (sudden loss of pressure on the plunger of the syringe, making the plunger slide smoothly) for identification of the epidural space, and what guidance can be provided to clinicians in their clinical practice? ...
  8. 16 Jul 2014
    Mannitol versus hypertonic saline for intraoperative brain relaxation in patients undergoing surgery for brain tumour New
    Review question: We reviewed evidence on the effectiveness of mannitol and hypertonic saline for brain relaxation in people having surgery (craniotomy) for brain tumour. Background: People with brain tumour undergo a craniotomy, or opening of the skull bone, for its removal. A relaxed brain allows the surgeon to remove the skull bone easily and to ...
  9. 16 Jul 2014
    Physician anaesthetists versus nurse anaesthetists for surgical patients New
    Background There is an increasing demand for surgery, pressure on healthcare providers to reduce costs, and a predicted shortfall in the number of medically qualified anaesthetists. This review aimed to consider whether anaesthesia can be provided equally effectively and safely by nurse anaesthetists (without medical qualifications) as by medically ...
  10. 9 Jul 2014
    Does daily sedation interruption reduce the time critically ill adults spend on breathing machines compared to other sedation strategies? New
    Background: critically ill patients require life-support technologies such as mechanical ventilation (breathing machines) and can experience pain, anxiety, and sleep deprivation related to their illness. Good pain control and adequate sedation are important but too much sedative drug can increase the time on breathing machines and the chance of harmful ...

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