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  1. 20 Nov 2014
    Treating unintentional hypothermia after surgery New
    Review question We wanted to find out the effects of different methods of rewarming adult patients with unintentional hypothermia (a core body temperature below 36°C) after surgery. Background Patients can get cold during surgery, particularly because of the drugs used as anaesthetics. This can cause potentially dangerous heart problems. Cold can ...
  2. 7 Nov 2014
    Anaesthetic techniques for risk of malignant tumour recurrence New
    Background Surgery remains a mainstay of treatment for patients with many types of cancer. However, surgical stress and certain anaesthesia and pain medications commonly given during anaesthesia for cancer surgery are known to suppress body defences. Therefore, surgery and anaesthesia might contribute to long-term cancer recurrence. Different types ...
  3. 6 Nov 2014
    The usefulness of weaning protocols for reducing the time critically ill adult patients spend on mechanical ventilation Updated
    Review question: We reviewed the evidence about the effect of weaning protocols (guidelines) used by clinicians on reducing the time that critically ill patients spent on a breathing machine. Background: Helping patients to breathe with the use of a mechanical ventilator can be life saving. Yet the longer someone stays on a ventilator, the greater the ...
  4. 28 Oct 2014
    Aquatic exercise training for fibromyalgia Podcast New
    Research question We reviewed studies on the effects of aquatic exercise training for people with fibromyalgia on wellness, symptoms, fitness, and adverse effects. Background: what is fibromyalgia and what is aquatic training? People with fibromyalgia have persistent, widespread body pain and often experience symptoms such as fatigue, stiffness, ...
  5. 16 Oct 2014
    Lidocaine for pain relief in people with burns
    Background Burns are very common and sometimes fatal, and the pain associated with such injury is one of the most difficult types to relieve. The use of high-dose opioid medications like morphine is common, but side effects are encountered. Alternative agents such as lidocaine, an anaesthetic, have been proposed. This is an update of the review of the ...
  6. 10 Oct 2014
    Intranasal fentanyl for the treatment of children in acute pain New
    Background Pain is the most common reason why patients are seen in emergency departments (EDs). The challenging nature of treating children in acute severe pain is reflected in the medical literature by poor pain management in this population. We reviewed evidence on the effect of intranasal fentanyl (INF) (a strong pain relief drug, similar to morphine) ...
  7. 23 Sep 2014
    Desipramine for neuropathic pain in adults
    Neuropathic pain is pain coming from damaged nerves. It is different from pain messages carried along healthy nerves from damaged tissue (a fall, cut, or arthritic knee). Neuropathic pain is treated by different medicines than pain from damaged tissue. Medicines like paracetamol or ibuprofen are not usually effective in neuropathic pain, while medicines ...
  8. 18 Sep 2014
    Influence of beta-blockers on perioperative adverse events
    Any type of surgery is associated with an increased stress response, which can make the body vulnerable to untoward outcomes. These outcomes may range from death to a heart attack and rhythm disturbances to heart failure, stroke and the like. Beta-blockers are drugs that attenuate this stress response, which results in slowing down of heart rate and ...
  9. 12 Sep 2014
    Agitation in children after sevoflurane anaesthesia
    Review question We reviewed the evidence looking at how often children wake up agitated after a sevoflurane general anaesthetic compared with other general anaesthetics. We also reviewed evidence looking at the effects of other treatments (e.g. a medication given during the anaesthetic, the presence of a parent when a child wakes up) on how often ...
  10. 9 Sep 2014
    SmartCare™ versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults
    The process of discontinuing mechanical ventilation is known as weaning. During weaning, the work of breathing is transferred from the ventilator to the patient. Weaning is typically achieved by clinicians reducing ventilator support and/or conducting tests to determine whether a patient can breathe on his/her own. SmartCare™ is a unique system that ...

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