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  1. 18 Sep 2014
    Influence of beta-blockers on perioperative adverse events New
    Any type of surgery is associated with an increased stress response, which can make the body vulnerable to untoward outcomes. These outcomes may range from death to a heart attack and rhythm disturbances to heart failure, stroke and the like. Beta-blockers are drugs that attenuate this stress response, which results in slowing down of heart rate and ...
  2. 12 Sep 2014
    Agitation in children after sevoflurane anaesthesia New
    Review question We reviewed the evidence looking at how often children wake up agitated after a sevoflurane general anaesthetic compared with other general anaesthetics. We also reviewed evidence looking at the effects of other treatments (e.g. a medication given during the anaesthetic, the presence of a parent when a child wakes up) on how often ...
  3. 9 Sep 2014
    Giving glutamine supplements to critically ill adults New
    Glutamine is a non-essential amino acid which is abundant in the healthy human body. There are studies reporting that muscle and plasma glutamine levels are reduced in patients with critical illness, or following major surgery, suggesting that the body's demand for glutamine is increased in these situations. In the past decade, several clinical trials ...
  4. 9 Sep 2014
    SmartCare™ versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults New
    The process of discontinuing mechanical ventilation is known as weaning. During weaning, the work of breathing is transferred from the ventilator to the patient. Weaning is typically achieved by clinicians reducing ventilator support and/or conducting tests to determine whether a patient can breathe on his/her own. SmartCare™ is a unique system that ...
  5. 21 Aug 2014
    Antioxidants to reduce pain in chronic pancreatitis New
    Chronic pancreatitis is a persistent inflammation of the pancreas that in the long run can cause irreparable damage. The major causes of chronic pancreatitis are genetics, alcohol toxicity and other conditions that might damage or obstruct the pancreas. This inflammation can cause pain that often is severe and leaves patients socially isolated and unable ...
  6. 14 Aug 2014
    Does giving patients carbohydrate supplements before planned surgery lead to improved recovery?
    Review question We reviewed the evidence on effects of carbohydrate supplements on the recovery of people undergoing planned surgical procedures. We found 27 studies investigating this question. Background Carbohydrate (sugar-containing) nutritional supplements have become a routine part of the package of care for people undergoing planned surgical ...
  7. 1 Aug 2014
    Is continuous positive airway pressure (CPAP) during the postoperative period useful? New
    Review question Does continuous positive airway pressure during the postoperative period help reduce death and major lung complications after major abdominal surgery? Background General anaesthesia can lead to reduced lung volumes and collapse of the alveoli as well as to reversible, patchy collapse of areas of lung (atelectasis) and subsequent ...
  8. 31 Jul 2014
    Does the administration of nalbuphine provide effective and safe postoperative pain treatment in children?
    Postoperative pain is still a major problem following surgery in children. There is currently clear evidence that multimodal postoperative pain treatment is the best choice. This approach may involve using nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids. However, due to the fear of side effects such as respiratory depression (where the lungs ...
  9. 25 Jul 2014
    Botulinum toxin injectable drug for myofascial pain syndrome (a painful condition that could affect any muscle in the body) in adults
    Myofascial pain syndrome (MPS) is a regional muscular pain syndrome characterised by the presence of trigger points (painful points) in one or more muscles. The pain can be at the trigger point site or it can be felt away from that point when the muscle is pressed, which is called referred pain. Botulinum toxin is a potent chemical that blocks the communication ...
  10. 24 Jul 2014
    Topical lidocaine for neuropathic pain in adults
    Neuropathic pain is pain coming from damaged nerves. It differs from pain messages carried along healthy nerves from damaged tissue (a fall, or cut, or arthritic knee). Neuropathic pain is treated by different medicines than pain from damaged tissue. Medicines like paracetamol or ibuprofen are usually not effective in neuropathic pain, while medicines ...

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