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Efavirenz or nevirapine in three-drug combination therapy with two nucleoside-reverse transcriptase inhibitors for initial treatment of HIV infection in adults

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  1. EFV and NVP are both equally effective in the suppression of HIV infection when compared as part of a three-drug combination.
    The introduction of highly active antiretroviral therapy as treatment for HIV infection has greatly reduced mortality and morbidity for adults and adolescents living with HIV around the world. The recommended initial treatments for HIV infection include two drugs from a class of drugs known as nucleoside reverse transcriptase inhibitors (NRTI) and one ...
  2. Comparing initial antiretroviral regimens tenofovir or zidovudine as part of three-drug combinations for treatment of HIV infection
    The introduction of highly active antiretroviral therapy (ART) as treatment for HIV infection has greatly improved mortality and morbidity for adults and adolescents living with HIV around the world. Deciding which treatment regimen to begin for first-line treatment in ART-naïve patients, however, remains a significant challenge. Two commonly used medications ...
  3. Comparing initial antiretroviral regimens stavudine or zidovudine as part of three-drug combinations for treatment of HIV infection
    The introduction of highly active antiretroviral therapy (ART) as treatment for HIV infection has greatly improved mortality and morbidity for adults and adolescents living with HIV around the world. Deciding which treatment regimen to begin for first-line treatment in ART-naïve patients, however, remains a significant challenge. Two of the most commonly ...
  4. Stavudine, lamivudine and nevirapine combination therapy for treatment of HIV infection and AIDS in adults
    People infected with HIV/AIDS require an antiretroviral regimen that works well, has good activity against the virus, has few adverse effects (unintended negative effects of the drug) and that does not interact with other drugs. The regimen of nevirapine, stavudine and lamivudine is widely used as first-line therapy, and is recommended as such by the ...
  5. Trizivir® for treating HIV infection and AIDS
    The primary objective of this review was to evaluate the antiviral efficacy of co-formulated zidovudine-lamivudine-abacavir (Trizivir®) for initial treatment of HIV infection. The secondary objectives were to evaluate the safety and tolerability of the triple drug combination. We identified nine potentially eligible studies, three of which met our inclusion ...
  6. Antiretroviral regimens for patients with HIV who fail first-line antiretroviral therapy
    Highly active antiretroviral therapy (HAART) has greatly reduced the illness and deaths of HIV-infected people worldwide. There are many options for first-line antiretroviral therapy (ART), but second-line therapy is necessary for people who fail the first-line treatment. This review attempted to assess the best ART regimen for HIV-infected people in ...
  7. Therapeutic drug monitoring of antiretroviral medications for people with HIV
    Monitoring the levels of HIV medications (antiretrovirals) in the blood of patients can reveal if levels are too high or too low. High levels may lead to side effects and low levels may not prevent the virus from multiplying. Prevention of virus replication is important for the immune system to recover and to fight diseases. The results from our review ...
  8. Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection
    At the end of 2009, 2.5 million children under the age of 15 years were estimated to be living with HIV/AIDS (WHO 2011). The majority of these children acquired their infections as a result of mother-to-child transmission during pregnancy, labor, or breastfeeding. Antiretroviral drugs administered to the HIV-infected mother and/or to her child during ...
  9. When is the best time to start antiretroviral therapy in people with HIV infection, who have not received antiretroviral treatment before and who do not have any symptoms of HIV illness?
    Antiretroviral therapy (ART) has been shown to be effective in slowing down the progression of AIDS and in reducing HIV-related illnesses and death. Traditionally, therapy is administered based on a patient’s CD4 cell count, where the number of CD4 cells reflects the body’s immune (defense) system.  An HIV-infected individual with a CD4 cell count of ...
  10. Therapy for treating HIV infection in pregnant women who require treatment for their own health Podcast
    Pregnant human immunodeficiency virus-infected (HIV)-infected women often need treatment with antiretroviral therapy (ART) for their own health. Mother-to-child transmission (MTCT) is the most common way that children worldwide become HIV infected. Treatment of HIV-infected pregnant women with ART decreases the risk of HIV MTCT. It is possible to decrease ...
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