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  1. 31 Oct 2014
    Cilostazol for peripheral arterial disease Updated
    Blockages in the arteries to the legs - peripheral arterial disease - affect 20% of people over 70 years of age and 4% to 12% of the population aged 55 to 70 years. Approximately 40% of those affected with peripheral arterial disease complain of pain in the legs on walking, this is known as intermittent claudication. Intermittent claudication is characterised ...
  2. 31 Oct 2014
    Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist-assisted reproductive technology cycles Updated
    Review question We reviewed the evidence on the effects of GnRH agonists on final oocyte maturation triggering in GnRH antagonist IVF/ICSI treatment cycles. Background Oocyte maturation triggering is the final differentiation process of an immature oocyte before fertilisation in unstimulated or stimulated cycles with assisted reproductive techniques. ...
  3. 30 Oct 2014
    Interventions for reducing difficulty in swallowing in people with oesophageal cancer Updated
    Review question For most patients with unresectable or inoperable oesophageal cancer, providing clinical benefit with palliative treatment is highly desirable. However, the optimal palliative technique for dysphagia improvement and better quality of life is not established. Background Dysphagia (difficulty or discomfort in swallowing) is common ...
  4. 30 Oct 2014
    Surgical approaches for dislocations of the neck bones New
    The part of the back bone found in the neck is called the cervical spine. It consists of seven bones (or vertebrae). The relative movement of these vertebrae is mainly via small joints (called facet joints) located between each vertebrae. The facet joints in the cervical spine facilitate good movement of the neck, but they are vulnerable to dislocation. ...
  5. 30 Oct 2014
    Treatment for epilepsy in pregnant women and the development of the child New
    Background For most women who have epilepsy it is important for their health that they continue their medication during pregnancy. Over the last 25 years research has shown that children exposed to these medications in the womb can be at a higher risk of having a birth defect or poorer level of development. Research question This review ...
  6. 30 Oct 2014
    Does administering colony-stimulating factors plus antibiotics in people with fever and low white cell count reduce hospitalization? Updated
    Background: People undergoing chemotherapy often experience febrile neutropenia, characterized by a high temperature combined with a low white blood cell count. Febrile neutropenia is a potentially life-threatening condition and requires prompt medical intervention. The standard treatment for febrile neutropenia includes supportive care of fluids, ...
  7. 30 Oct 2014
    Eculizumab for treating patients with paroxysmal nocturnal hemoglobinuria New
    Review question We reviewed the evidence about the effects of eculizumab for treating patients with paroxsymal nocturnal hemoglobinuria. Background Paroxysmal nocturnal hemoglobinuria is a disorder of the hematopoietic stem cells (a cell that can self renew and differentiate into one or more cell types). It is characterized by episodes of intravascular ...
  8. 29 Oct 2014
    Surgical treatments for pectus excavatum New
    Pectus excavatum is characterized by a depression (sunken appearance) of the anterior (front) chest wall (sternum and lower costal cartilages); it is the most common chest wall defect. The frequency ranges from 6.28 to 12 cases per 1000 around the world. It is generally regarded as a genetic condition, based on the fact that it is usually present in ...
  9. 29 Oct 2014
    Antenatal screening tests for the prevention and treatment of syphilis New
    Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. A major public health issue in developing countries, the condition develops over four stages and is potentially fatal if untreated. A pregnant woman with syphilis can transmit the infection to her baby, which may result in a severe condition in liveborn infants, ...
  10. 29 Oct 2014
    Antibiotics for rupture of membranes when a pregnant women is at or near term but not in labour Updated
    Background Sometimes the protective bag of fluid around an unborn baby (the membranes) break when the baby is due without the onset of labour (regular uterine contractions). This is called PROM or prelabour rupture of the membranes. When this happens there is a risk of infection entering the womb (uterus) and affecting the mother and her baby. Newborn ...

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