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  1. 1 Oct 2014
    Antibiotic treatment for the prevention of Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients Updated
    Pneumocystis jiroveci is a fungus causing pneumonia mainly among patients with an impaired immune system, such as those infected with the human immunodeficiency virus (HIV), cancer patients, following organ transplantation, and patients receiving immune suppressive medications. Previous evidence shows that preventive antibiotic treatment (before the ...
  2. 1 Oct 2014
    Bias due to selective inclusion and reporting of outcomes and analyses in systematic reviews of randomised trials of healthcare interventions New
    A systematic review summarises evidence from multiple studies to answer a specific research question (e.g. what are the benefits and harms of a particular intervention for a particular health condition?). Often, there are many outcomes that systematic review authors could report to address their research question (e.g. pain, disability and quality of ...
  3. 1 Oct 2014
    Electrotherapy modalities for adhesive capsulitis (frozen shoulder) New
    Background Frozen shoulder is a common cause of shoulder pain and stiffness. The pain and stiffness can last up to two to three years before going away, and in the early stages it can be very painful. Electrotherapy modalities (also known as electrophysical agents) are types of physical therapy that aim to reduce pain and improve function via an increase ...
  4. 30 Sep 2014
    Azapirones versus placebo for panic disorder in adults New
    Why is this review important? Panic disorder is common in the general population and is often associated with various psychiatric disorders. Azapirones are a class of drugs occasionally used in the treatment of panic disorder, although none has been approved by a regulatory agency for this purpose. They are associated with less drowsiness, psychomotor ...
  5. 29 Sep 2014
    Lowering the dose of or stopping anti-TNF drugs in people with rheumatoid arthritis who are doing well New
    We conducted a review of studies in which the dose of anti-TNF drugs (adalimumab, certolizumab pegol, etanercept, golimumab and infliximab) was lowered or treatment was stopped in people with rheumatoid arthritis (RA) who use anti-TNFs and are doing well. Upon systematically searching for all relevant studies up to September 2013, we found seven studies ...
  6. 27 Sep 2014
    Surgery for urinary incontinence due to presumed sphincter deficiency after prostate surgery Updated
    Background Urinary leakage (incontinence) after surgery to remove the prostate (prostatectomy) for benign or malignant disease is a well-known and often feared outcome. Although a small amount of incontinence may not cause a problem, larger degrees of incontinence can have a major impact on a man's quality of life. Improvement in urinary leakage may ...
  7. 26 Sep 2014
    Repeated use of hormonal drugs right before or after sex to prevent pregnancy Updated
    Currently, no oral birth control method is approved for using only when needed, that is, at the time of sex. However, many women may want to use such a method. Our review looked at studies of different drugs taken around the sex act to find out how well the drugs worked to prevent pregnancy. We also assessed the safety of the drugs and whether women ...
  8. 25 Sep 2014
    Centre-based day care for children younger than five years of age in low- and middle-income countries New
    Review question This review evaluated the effects of centre-based day care for children younger than five years of age in low- and middle-income countries (as defined by the World Bank 2011). We considered the following outcomes: children's cognitive and psychosocial development, prevalence and incidence of infectious diseases among them and the economic ...
  9. 25 Sep 2014
    Interventions for the management of oral ulcers in Behçet's disease New
    Review question This review has been conducted to assess the effects of different interventions, administered systemically or topically, for the prevention or treatment of oral ulcers in people with Behçet's disease. The interventions could be compared with an alternative intervention, no intervention or the administration of a placebo. Background ...
  10. 23 Sep 2014
    Desipramine for neuropathic pain in adults New
    Neuropathic pain is pain coming from damaged nerves. It is different from pain messages carried along healthy nerves from damaged tissue (a fall, cut, or arthritic knee). Neuropathic pain is treated by different medicines than pain from damaged tissue. Medicines like paracetamol or ibuprofen are not usually effective in neuropathic pain, while medicines ...

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