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  1. 20 Apr 2014
    Which is the most suitable source of donor blood-forming (stem) cells for transplanting into adults with blood cancers? New
    Stem cell transplantation Stem cell transplantation is an important treatment option for individuals with blood cancers (haematological malignancies). During the procedure, blood-forming (stem) cells, derived from the bone marrow, peripheral blood or umbilical cord blood of a healthy donor, are transplanted into a person with a blood cancer. The aim ...
  2. 17 Apr 2014
    Rapid diagnostic tests versus clinical diagnosis for managing fever in settings where malaria is common New
    Cochrane Collaboration researchers conducted a review of the effects of introducing rapid diagnostic tests (RDTs) for diagnosing malaria in areas where diagnosis has traditionally been based on clinical symptoms alone. After searching for relevant trials, they included seven randomized controlled trials, which enrolled 17,505 people with fever. What ...
  3. 16 Apr 2014
    The WHO Health Promoting School framework for improving the health and well-being of students and their academic achievement New
    Background Health and education are strongly connected: healthy children achieve better results at school, which in turn are associated with improved health later in life. This relationship between health and education forms the basis of the World Health Organization's (WHO’s) Health Promoting Schools (HPS) framework, an approach to promoting health ...
  4. 16 Apr 2014
    Treatments for accidental damage during surgery to the nerves supplying sensation to the tongue, lower lip and chin New
    Review question The main question addressed by this review is how effective are different treatments and what are the best timings for these treatments following accidental damage during surgery to the nerves that supply sensation to the tongue, lower lip and chin. Background The nerves (alveolar and lingual) supplying sensation to the tongue, lower ...
  5. 15 Apr 2014
    Keyhole laparoscopic or open surgery for rectal cancer Updated
    Colorectal (large bowel) cancer including rectal cancer is the third most common cause of cancer deaths in the western world. The risk of developing rectal cancer increases with age and is most common in people around 70 years of age. The treatment consists of complete surgical resection of the tumour and surrounding tissue by a technique called total ...
  6. 15 Apr 2014
    Fixed-dose combination therapy for the prevention of cardiovascular disease New
    Cardiovascular diseases (CVD), including heart attacks and strokes, are the leading cause of death and disability worldwide. Drug therapy with blood pressure and cholesterol lowering medications, particularly statins, have been proven to reduce the likelihood that individuals will experience a fatal or non-fatal cardiovascular event. Aspirin has also ...
  7. 14 Apr 2014
    Vitamin D and related vitamin D compounds for preventing fractures resulting from osteoporosis in older people Updated
    Why do older people suffer bone fractures? Hip fractures and several other types of fractures are very common in post-menopausal women and older men due to age-related weakening of their bones (osteoporosis). What is the impact of bone fractures in older people? Fractures due to osteoporosis often occur in the hip, wrist or spine and can lead to ...
  8. 14 Apr 2014
    Planned home versus hospital care for rupture of the membranes before 37 weeks' gestation Updated
    Premature rupture of membranes before 37 weeks’ gestation (and where there is at least an hour between membrane rupture and the onset of contractions and labour) can have consequences for both the mother and the baby. It is estimated that after premature rupture of the membranes one-half of women go into labour within a week, and three-quarters within ...
  9. 14 Apr 2014
    Shengmai (a traditional Chinese herbal medicine) for heart failure Updated
    Heart failure is a major public health issue worldwide. Despite advances in treatment, many people are affected and hundreds of thousand of people die each year. Shengmai is a traditional Chinese herbal medicine and is a mixture extracted from three herbs: Panax ginseng, Ophiopogon japonicus and Schisandra chinensis. In China it has been used to treat ...
  10. 11 Apr 2014
    Different regimens of intravenous sedatives or hypnotics for electroconvulsive therapy (ECT) in adult patients with depression New
    Depression is a common mental disorder. It can present as loss of interest or pleasure, sadness, disturbed sleep or appetite, feelings of guilt or low self worth. In 2008, the World Health Organization (WHO) estimated that depression was the second leading cause of disability-adjusted life-years among all men and women between 15 and 44 years of age. ...

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