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Soy oil based versus alternative lipid emulsions for parenterally fed preterm infants

Kapoor V, Glover R, Malviya MN
Published Online: 
15 June 2011
This Cochrane Review is at the protocol stage and there is no abstract or plain language summary. The objectives for the review are as follows:
Primary objectives

To compare the effects of soybean oil based lipid emulsions (SO-LE) versus alternative LE (olive oil based LE (OO-LE), medium chain triglyceride (MCT) oil based LE, structured LE, fish oil based LE or multi-combination LE) on: a) death, b) physical growth, c) chronic lung disease, and d) long term neuro-developmental outcomes in parenterally fed preterm infants. We would like to do separate comparisons for SO-LE and each of the different alternatives wherever the studies are available.

Each available lipid emulsion type will be compared separately with SO-LE giving us five comparison groups:

  1. SO-LE versus OO-LE;
  2. SO-LE versus MCT-LE (pure MCT-LE and mixed MCT/LCT-LE);
  3. SO-LE versus structured lipids (structured MCT/LCT-LE);
  4. SO-LE versus FO-LE;
  5. SO-LE versus multi-combination LE.

We would also consider studies which compare one non-soy alternative to another as a separate analysis, if feasible.

Secondary objectives

To compare the effects of SO-LE versus alternative LE (OO-LE, MCT-LE, structured LE, FO-LE or multi-LE) on morbidities associated with prematurity and PNALD in parenterally fed preterm infants.

Subgroup analysis will be performed based on: a) population type {gestational age (< 30 weeks, ≥ 30 weeks); gender; birth weight (≤ 1000 g, > 1000g); congenital malformations} and b) intervention type, early (≤ 3 days) versus late (4 to 7 days) introduction of LE; low dose (≤ 2 g/kg/day) versus high dose LE (> 2 g/kg/day); maximum dose from day 1 versus gradual increment of LE.

This record should be cited as: 
Kapoor V, Glover R, Malviya MN. Soy oil based versus alternative lipid emulsions for parenterally fed preterm infants. Cochrane Database of Systematic Reviews 2011, Issue 6. Art. No.: CD009172. DOI: 10.1002/14651858.CD009172
Assessed as up to date: 
4 May 2011