Cystic fibrosis is an inherited condition causing disease most noticeably in the lungs, digestive tract and pancreas. People with cystic fibrosis often have pancreatic insufficiency which may be linked to deficiencies of fat-soluble vitamins like vitamin K. Vitamin K is needed for adequate blood clotting, bone formation and some metabolic functions.
This review looked at giving vitamin K supplements to address the effects of deficiency on blood clotting, bone strength and quality of life in people with cystic fibrosis. We tried to determine the optimal dosage required to prevent this deficiency.
Data from two small trials did not clearly indicate whether giving vitamin K supplements will improve blood clotting, bone strength or quality of life in people with cystic fibrosis. We were not able to draw firm conclusions from this review and advise that the current recommendations from the Cystic Fibrosis Foundation and the European Cystic Fibrosis Society should be followed until further evidence becomes available.