Cochrane Summaries

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Statins can help reduce risk of death in people with chronic kidney disease who do not need dialysis

Palmer SC, Navaneethan SD, Craig JC, Johnson DW, Perkovic V, Hegbrant J, Strippoli GFM
Published Online: 
31 May 2014

Adults with chronic kidney disease (CKD) have high risks of developing complications from heart disease. It is thought that statin treatment lowers cholesterol and reduces risk of death and complications from heart disease.

We looked at 50 studies published before June 2012 concerning statin treatment in over 45,000 people with CKD who did not need dialysis treatment. We found that statins reduced the risk of death and major heart-related events by 20%. Statin treatment was also found to be effective in reducing cardiac disease and death in people who have CKD but not heart disease. In these people, statin treatment reduced risks of heart attack by half.

Statins have some potential harmful effects on liver and muscle function, and some cancers. We found that these issues were not analysed well in the studies we evaluated, and these effects are not well understood.

Although use of statins did not clearly reduce risks of kidney disease progression, they can be recommended to reduce risks of death and heart-related events in people with early stages of kidney disease. However, the potential side-effects are uncertain, and need further study.

This record should be cited as: 
Palmer SC, Navaneethan SD, Craig JC, Johnson DW, Perkovic V, Hegbrant J, Strippoli GFM. HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis. Cochrane Database of Systematic Reviews 2014, Issue 5. Art. No.: CD007784. DOI: 10.1002/14651858.CD007784.pub2
Assessed as up to date: 
5 June 2012