Chronic wounds include pressure ulcers, venous leg ulcers, arterial ulcers, neurotrophic ulcers and foot ulcers in people with diabetes. Autologous platelet-rich plasma (PRP) is a potential wound-healing treatment because it contains fibrin and high concentrations of growth factors that are thought to help healing. This review evaluated the effectiveness and safety of PRP and included nine randomised clinical trials, with a total of 325 participants. There were no differences between the autologous PRP and the control groups in terms of healing. However, these results require confirmation in adequately powered, well conducted RCTs.
Autologous platelet-rich plasma (PRP) for chronic wounds
17 October 2012
This record should be cited as:
Martinez-Zapata MJ, Martí-Carvajal AJ, Solà I, Expósito JA, Bolíbar I, Rodríguez L, Garcia J. Autologous platelet-rich plasma for treating chronic wounds. Cochrane Database of Systematic Reviews 2012, Issue 10. Art. No.: CD006899. DOI: 10.1002/14651858.CD006899.pub2
Assessed as up to date:
15 August 2012
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