Cochrane Summaries

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Autologous platelet-rich plasma (PRP) for chronic wounds

Martinez-Zapata MJ, Martí-Carvajal AJ, Solà I, Expósito JA, Bolíbar I, Rodríguez L, Garcia J
Published Online: 
17 October 2012

Chronic wounds include pressure ulcers, venous leg ulcers, arterial ulcers, neurotrophic ulcers and foot ulcers in people with diabetes. Autologous platelet-rich plasma (PRP) is a potential wound-healing treatment because it contains fibrin and high concentrations of growth factors that are thought to help healing. This review evaluated the effectiveness and safety of PRP and included nine randomised clinical trials, with a total of 325 participants. There were no differences between the autologous PRP and the control groups in terms of healing. However, these results require confirmation in adequately powered, well conducted RCTs.