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Immunotherapy for diabetic amyotrophy

Chan YC, Lo YL, Chan ESY
Published Online: 
July 8, 2009

Results from trials are awaited to show whether corticosteroids, immunoglobulin or other treatments that act on the immune system are beneficial in diabetic amyotrophy.

Diabetic amyotrophy or diabetic lumbosacral radiculoplexus neuropathy is an uncommon disorder of the peripheral nerves associated with diabetes mellitus. It causes pain and weakness in the lower limbs. Some researchers have found inflammatory cells near blood vessels and suggested that these interrupt blood supply to the nerves. They suggest that medications that reduce the inflammatory cells may be helpful. We found only one completed trial but the results have not been fully published and were not available for analysis. There is presently no evidence from any trial to show whether immunotherapies may benefit people with this condition.

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