Published Online:
May 11, 2011
This is the protocol for a review and there is no abstract. The objectives are as follows:
Our aim is to determine the benefits and harms of bisphosphonate therapy for men with prostate cancer without clinically evident metastases.
Specific primary objective
To determine the effects of bisphosphonates in men with prostate cancer but without clinically evident metastases on:
i) the incidence of skeletal metastases and their associated clinical complications;
ii) bone mineral density and secondary osteoporotic skeletal complications.
Secondary objectives include the effect of bisphosphonates on:
- time to first skeletal complication;
- skeletal metastasis event rate;
- overall survival;
- quality of life;
- toxicity.