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Sildenafil for pulmonary hypertension in neonates

Shah PS, Ohlsson A
Published Online: 
10 August 2011

Some babies develop persistent pulmonary hypertension of the neonate (PPHN), a condition where the pressure in the blood vessels that allows blood to flow to the lungs remains abnormally high. Persistent high pressure in these vessels leads to less blood flow to the lungs and therefore less oxygen reaching the blood and all organs of the body. Sildenafil may cause these vessels to relax and allow for improved blood flow and improved oxygen delivery to all organs. This treatment is especially useful in the settings where other treatment approaches are not available. However, in resourceful environment, further studies are needed to compare sildenafil with existing treatment for effect and safety.

This record should be cited as: 
Shah PS, Ohlsson A. Sildenafil for pulmonary hypertension in neonates. Cochrane Database of Systematic Reviews 2011, Issue 8. Art. No.: CD005494. DOI: 10.1002/14651858.CD005494.pub3
Assessed as up to date: 
30 April 2010