There is no evidence to establish the beneficial or harmful effects of vitamin K for upper gastrointestinal bleeding in patients with liver diseases

Martí-Carvajal AJ, Cortés-Jofré M, Martí-Peña AJ

Published Online:

January 21, 2009

Upper gastrointestinal bleeding is one of the most frequent causes of morbidity and mortality in the course of liver cirrhosis. Vitamin K administration is used as a supplementary intervention, but it is unknown whether it benefits or harms patients with liver disease and upper gastrointestinal bleeding. This updated review found no randomised clinical trials on the safety and efficacy of vitamin K for upper gastrointestinal bleeding in patients with liver diseases.

Abstract (click to read)

Background:

Upper gastrointestinal bleeding is one of the most frequent causes of morbidity and mortality in the course of liver cirrhosis. Several treatments are used for upper gastrointestinal bleeding in patients with liver diseases. One of them is vitamin K administration, but it is unknown whether it benefits or harms patients with liver disease and upper gastrointestinal bleeding.

Objectives:

To assess the beneficial and harmful effects of vitamin K for patients with liver disease and upper gastrointestinal bleeding.

Search strategy:

We searched The Cochrane Hepato-Biliary Group Controlled Trials Register (September 2007), which comprises references identified from comprehensive electronic database searches and handsearching of relevant journals and abstract books of conference proceedings, The Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (Issue 3, 2007), MEDLINE (1950 to September 2007), EMBASE (1980 to September 2007), Science Citation Index Expanded (1945 to September 2007), and LILACS (1982 to November 2007). Additional randomised trials were sought from two registries of clinical trials, ClinicalTrials.gov and Sistema de Información Esencial en Terapéutica y Salud, the reference lists of the trials found, and reviews identified by the electronic searches.

Selection criteria:

Randomised clinical trials.

Data collection and analysis:

Data from randomised clinical trials were to be summarised by standard Cochrane Collaboration methodologies.

Main results:

We could not find any randomised trials on vitamin K for upper gastrointestinal bleeding in patients with liver diseases.

Authors' conclusions:

This updated review found no randomised clinical trials on the safety and efficacy of vitamin K for upper gastrointestinal bleeding in patients with liver diseases. The effects of vitamin K need to be tested in randomised clinical trials. Unless randomised clinical trials provide evidence of a treatment effect and the trade off between potential benefits and harms are established, policy-makers, clinicians, and academics should not use vitamin K for upper gastrointestinal bleeding in patients with liver diseases.

This record should be cited as:

Martí-Carvajal AJ, Cortés-Jofré M, Martí-Peña AJ. Vitamin K for upper gastrointestinal bleeding in patients with liver diseases. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD004792. DOI: 10.1002/14651858.CD004792.pub3

Assessed as up to date:

November 12, 2007

Find the research

Get full text at The Cochrane Library

Primary Review Group:

Hepato-Biliary Group

Health topics:

Gastroenterology > Oesophageal & gastric varices > Acute (& first time) bleeding gastric varices

Gastroenterology > Oesophageal & gastric varices > Acute (& first time) bleeding oesophageal varices

Complementary & alternative medicine > Gastroenterology > Oesophageal & gastric varices

Cochrane Summaries^beta

Independent high-quality evidence for health care decision making

There is no evidence to establish the beneficial or harmful effects of vitamin K for upper gastrointestinal bleeding in patients with liver diseases

More like this

Copyright © 2012 - The Cochrane Collaboration