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Single dose oral diclofenac for pain relief in adults experiencing moderate or severe pain following a surgical procedure

Derry P, Derry S, Moore RA, McQuay HJ
Published Online: 
9 November 2011

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) with pain relieving properties. It is used to treat many painful conditions, including acute postoperative pain. This review shows that single dose oral diclofenac provides effective pain relief for adults experiencing moderate or severe pain following a surgical procedure. For every five participants with moderate to severe postoperative pain treated with a single dose of diclofenac, two would experience at least 50% pain relief who would not have done so with placebo. One form of diclofenac, the potassium salt, is more effective at the same dose than the other form of diclofenac, the sodium salt. The incidence of adverse effects did not differ significantly from placebo in these single dose studies.

This record should be cited as: 
Derry P, Derry S, Moore RA, McQuay HJ. Single dose oral diclofenac for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2009, Issue 2. Art. No.: CD004768. DOI: 10.1002/14651858.CD004768.pub2
Assessed as up to date: 
15 September 2011