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The nasal antibiotic prophylactic mupirocin reduces exit-site/tunnel infection and preoperative intravenous antibiotic prophylaxis reduces early peritonitis in peritoneal dialysis

Strippoli GFM, Tong A, Johnson DW, Schena FP, Craig JC
Published Online: 
14 April 2010

People with advanced kidney disease may be treated with peritoneal dialysis where a catheter is permanently inserted into the peritoneum (lining around abdominal contents) through the abdominal wall and sterile fluid is drained in and out a few times each day. The most common serious complication is infection of the peritoneum - peritonitis. This may be caused by bacteria accidentally being transferred from the catheter. This review found that nasal mupirocin reduces exit-site/tunnel infection but not peritonitis while preoperative intravenous antibiotic prophylaxis reduces early peritonitis but not exit-site/tunnel infection. More large scale trials are needed.