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No evidence of benefit from vitamin B6 supplementation on mood or cognition of older people with normal vitamin B6 status or with vitamin B6 deficiency

Malouf R, Grimley Evans J
Published Online: 
16 July 2008

Micronutrient status can affect cognitive function at all ages. Vitamin deficiencies could influence memory function and might contribute to age-associated cognitive impairment and dementia. Vitamin B6 is involved in the regulation of mental function and mood and in the metabolism of homocysteine, a risk factor for vascular disease. Two trials of vitamin B6 supplements for healthy elderly people qualified for this review, with no beneficial effects on mood or mental function detectable. Homocysteine levels were not assessed. No ill effects of vitamin B6 were observed. No trials studying effects of vitamin B6 treatment for people with dementia or cognitive impairment were identified.

This record should be cited as: 
Malouf R, Grimley Evans J. Vitamin B6 for cognition. Cochrane Database of Systematic Reviews 2003, Issue 4. Art. No.: CD004393. DOI: 10.1002/14651858.CD004393
Assessed as up to date: 
3 April 2008