Cochrane Summaries

Trusted evidence. Informed decisions. Better health.

There is no strong evidence that adults with nephrotic syndrome have a long-term benefit from treatment with immunosuppressive drugs

Schieppati A, Perna A, Zamora J, Giuliano GA, Braun N, Remuzzi G
Published Online: 
8 July 2009

Nephrotic syndrome is a condition where the kidneys leak protein from the blood into the urine. Idiopathic membranous nephropathy (IMN) in adults is the most common form of this syndrome. Most adults with IMN will have a complete or partial remission, but at least a third will eventually develop kidney failure. The review of trials found that there is no strong evidence that immunosuppressive drugs have a long-term effect on survival or kidney health. The drugs may increase the rate of remission, but the evidence was not conclusive. Adverse effects include stomach disorders and a reduction in white blood cells.