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Single dose oral naproxen and naproxen sodium for acute postoperative pain in adults

Derry CJ, Derry S, Moore RA, McQuay HJ
Published Online: 
9 November 2011

This review assessed evidence from 1509 participants in 15 randomised, double blind, placebo-controlled clinical trials of naproxen or naproxen sodium (a non-steroidal anti-inflammatory drug) in adults with moderate to severe acute postoperative pain. At doses equivalent to 500 mg and 400 mg, orally administered naproxen provides effective analgesia. About half of those treated experienced at least half pain relief over four to six hours, and the effects lasted, on average, up to nine hours. Associated adverse events did not differ from placebo, but these studies are of limited use for studying adverse effects.

This record should be cited as: 
Derry CJ, Derry S, Moore RA, McQuay HJ. Single dose oral naproxen and naproxen sodium for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2009, Issue 1. Art. No.: CD004234. DOI: 10.1002/14651858.CD004234.pub3
Assessed as up to date: 
15 September 2011