Glaucoma is a chronic progressive disease of the optic nerve which, if not treated, leads to visual field decay and blindness at end stages. Intraocular pressure (IOP) decreasing is shown to diminish the progression of the disease, and could be achieved by the chronic use of hypotensive eyedrops, incisional surgery or laser trabeculoplasty. There is still great controversy about where in the treatment scale laser trabeculoplasty is positioned, although this technique has already been described three decades ago. This treatment consists of application of laser spots in the trabecular meshwork, the structure responsible for the aqueous humor drainage, leading to an increase in the outflow facility through it and in consequence, decreasing IOP. It is an interesting form of treatment since it does not depend on chronic instillation of eyedrops, as does medical treatment, and also does not have too many complications, as does incisional surgery. This review included 19 trials (2137 participants). One trial compared laser trabeculoplasty associated with a hypotensive eyedrop with no intervention, and at six years of follow up the risk of visual field decay was greater in non treated participants. Three trials compared hypotensive eyedrops with trabeculoplasty, and the risk of uncontrolled IOP was greater at two years in the laser group. It is necessary to mention that the eyedrops used in these trials differ significantly from the ones used currently, since these trials were developed a decade ago. Three other trials compared trabeculoplasty with trabeculectomy and the risk of uncontrolled IOP was higher in the laser group at six months of follow up. There is some evidence showing that diode laser and selective trabeculoplasty have similar effect in controlling IOP when compared to argon laser trabeculoplasty. Comparisons of different lasers and different techniques of application were done in the remaining trials, but there is still not enough evidence to determine which is the best treatment protocol. Further research is necessary to compare trabeculoplasty with new hypotensive eyedrops and also the results of laser therapy in people of different ethnicities, since some studies suggest that they have a different response to this kind of laser therapy. More research is required to analyse cost-effectiveness of these interventions.