Tinnitus is described as the perception of sound or noise in the absence of real acoustic stimulation, and is frequently associated with depression or depressive symptoms. Six studies matched the inclusion criteria for this review. Four evaluated three tricyclic antidepressant agents (amitriptyline, nortriptyline and trimipramine) for the treatment of tinnitus. These studies did not find enough evidence to prove the efficacy of these agents in the management of tinnitus. One study evaluated paroxetine, a selective serotonin reuptake inhibitor antidepressant, and one evaluated trazodone, an atypical antidepressant. Neither of these studies showed benefit of paroxetine in the treatment of tinnitus. Side effects, though relatively minor, were common in all groups of antidepressants. Further research is required.