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No evidence supporting or refuting milk thistle for alcoholic and/or hepatitis B or C virus liver diseases

Rambaldi A, Jacobs BP, Gluud C
Published Online: 
21 January 2009

Milk thistle (Silybum marianum (L) Gaertneri) extracts have been used as medical remedies since the time of ancient Greece. Alcohol and hepatotoxic viruses are the major causes of liver diseases. Several trials have studied the effects of milk thistle for patients with liver diseases. This systematic review could not demonstrate significant effects of milk thistle on mortality or complications of liver diseases in patients with alcoholic and/or hepatitis B or C liver diseases combining all trials or high-quality trials. Low-quality trials suggested beneficial effects. High-quality randomised clinical trials on milk thistle versus placebo are needed.

This record should be cited as: 
Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD003620. DOI: 10.1002/14651858.CD003620.pub3
Assessed as up to date: 
14 January 2005