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Daily intake of 1 gr dietary calcium may have moderate protective effect on development of colorectal adenomatous polyps

Weingarten MAMA, Zalmanovici Trestioreanu A, Yaphe J
Published Online: 
8 September 2010

There have been suggestions, based on observational studies and on laboratory markers, that dietary calcium may protect against colorectal cancer. This systematic review of the literature identified two well conducted randomised placebo-controlled intervention studies involving 1346 subjects followed for 3-4 years. The results suggest that there may be a moderate protective effect (OR 0.74; CI 0.58,0.95) for dietary supplementation of at least 1200mg elemental calcium per day on the development of colorectal adenomatous polyps. However, no trial has directly demonstrated an effect of calcium supplementation on the development of colorectal cancer itself.