There have been suggestions, based on observational studies and on laboratory markers, that dietary calcium may protect against colorectal cancer. This systematic review of the literature identified two well conducted randomised placebo-controlled intervention studies involving 1346 subjects followed for 3-4 years. The results suggest that there may be a moderate protective effect (OR 0.74; CI 0.58,0.95) for dietary supplementation of at least 1200mg elemental calcium per day on the development of colorectal adenomatous polyps. However, no trial has directly demonstrated an effect of calcium supplementation on the development of colorectal cancer itself.
Daily intake of 1 gr dietary calcium may have moderate protective effect on development of colorectal adenomatous polyps
8 September 2010
This record should be cited as:
Weingarten MAMA, Zalmanovici Trestioreanu A, Yaphe J. Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD003548. DOI: 10.1002/14651858.CD003548.pub4
Assessed as up to date:
21 January 2010
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