Autologous chondrocyte implantation for full thickness articular cartilage defects of the knee

Vasiliadis HS, Wasiak J

Published Online:

July 6, 2011

A layer of cartilage covering the knee joint surfaces acts to protect the joint and reduce friction. Damage to the cartilage (articular surface) can decrease mobility of the joint and cause pain on movement. Continuing deterioration of the surface may lead to osteoarthritis. Treatments for damaged cartilage include relieving symptoms, surgically cleaning up the joint, or surgically re-establishing the cartilage layer. The latter is done using marrow stimulation techniques (such as microfracture), mosaicplasty (also known as osteochondral cylinder transplantation), and more recently with implantation of healthy cartilage cells (chondrocytes). In the technique of autologous chondrocyte implantation (ACI), a small piece of cartilage is retrieved from the knee joint. This piece is brought to a laboratory where it is digested to free the chondrocyte cells; these cells are subsequently cultured in a culture media in order to expand the numbers of cells. Then, with a second surgery, the cells are placed into the joint defect in an effort to produce a tissue that substitutes the normal cartilage.

This review includes six small randomised controlled trials that compared ACI with either mosaicplasty or microfracture. Although there are some promising results for ACI compared with microfracture from one trial, the evidence from two other trials testing the same comparison did not confirm these. None of the other three trials testing different comparisons provided conclusive evidence in favour of ACI, although the longer-term results suggest that the results for some types of ACI may improve over time. The review identified several ongoing trials that should help to provide evidence to inform on the use of ACI in the future. Meanwhile, there is insufficient evidence to draw conclusions on the use of ACI.

Abstract (click to read)

Background:

Treatments for managing articular cartilage defects of the knee, including drilling and abrasion arthroplasty, are not always effective. When they are, long-term benefits may not be maintained and osteoarthritis may develop. An alternative is autologous chondrocyte implantation (ACI), the surgical implantation of healthy cartilage cells into the damaged areas.

Objectives:

To determine the efficacy and safety of ACI in people with full thickness articular cartilage defects of the knee.

Search strategy:

We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register (14 January 2011), the Cochrane Central Register of Controlled Trials (The Cochrane Library 2010, Issue 4), MEDLINE (1948 to January Week 1 2011), EMBASE (1980 to Week 1 2011), SPORTDiscus (1985 to 14 January 2011), the WHO International Clinical Trials Registry Platform (26 January 2011), and Current Controlled Trials (26 January 2011).

Selection criteria:

Randomised and quasi-randomised trials comparing ACI with any other type of treatment (including no treatment or placebo) for symptomatic cartilage defects of the medial or lateral femoral condyle, femoral trochlea or patella.

Data collection and analysis:

Review authors selected studies for inclusion independently. We assessed risk of bias based on adequacy of the randomisation and allocation concealment process, potential for selection bias after allocation and level of masking. We did not pool data due to clinical and methodological heterogeneity.

Main results:

Six heterogeneous trials were identified with 442 participants. Methodological flaws of the included trials included incomplete follow-up and inadequate reporting of outcomes. Three trials compared ACI versus mosaicplasty. One reported statistically significant results in favour of ACI at one year in the numbers of people with 'good' or 'excellent' functional results. Conversely, another trial found significant improvement for the mosaicplasty group when assessed using one functional scoring system at two years, but no statistically significant differences based on two other scoring systems. A third trial found no difference between ACI and mosaicplasty, 10 months on average after the surgery.

There was no statistically significant difference in functional outcomes at two years in a single trial comparing ACI with microfracture nor in the functional results at 18 months of a single trial comparing characterised chondrocyte implantation versus microfracture. However, the results at 36 months for this trial seemed to indicate better functional results for characterised chondrocyte implantation compared with those for microfracture. The sixth trial comparing matrix-guided ACI versus microfracture found significantly better results for functional outcomes at two year follow-up in the MACI group.

Authors' conclusions:

There is insufficient evidence to draw conclusions on the use of ACI for treating full thickness articular cartilage defects in the knee. Further good quality randomised controlled trials with long-term functional outcomes are required.

This record should be cited as:

Vasiliadis HS, Wasiak J. Autologous chondrocyte implantation for full thickness articular cartilage defects of the knee. Cochrane Database of Systematic Reviews 2010, Issue 10. Art. No.: CD003323. DOI: 10.1002/14651858.CD003323.pub3

Assessed as up to date:

April 14, 2011

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Primary Review Group:

Bone, Joint and Muscle Trauma Group

Health topics:

Orthopaedics & trauma > Soft tissue injuries > Appendicular skeleton

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Independent high-quality evidence for health care decision making

Autologous chondrocyte implantation for full thickness articular cartilage defects of the knee

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