Cromolyn sodium for the prevention of chronic lung disease in preterm infants

Cromolyn sodium administered in the first few days of life has not been shown to prevent chronic lung disease in preterm infants. Preterm babies (babies born before 37 weeks gestation) often need to be given oxygen for lung problems for many weeks because of chronic lung disease. This is due, in part, to inflammation (swelling) within the lungs. Theoretically, cromolyn sodium is a drug that might help prevent this inflammation. It is relatively safe and adverse effects are rare. It can be given by nebuliser or aerosol inhaler in the first few days in an attempt to prevent chronic lung disease. However, this review of trials found no strong evidence that cromolyn sodium can prevent or reduce chronic lung disease and further research does not seem to be justified.