Cochrane Summaries

Trusted evidence. Informed decisions. Better health.

Vitamin E should not be used for the treatment of mild cognitive impairment (MCI) and Alzheimer's dementia (AD)

Farina N, Isaac MGEKN, Clark AR, Rusted J, Tabet N
Published Online: 
14 November 2012

Vitamin E is a dietary compound that has strong antioxidant properties. Vitamin E has been shown to act on some toxic chemicals that may contribute to the damage seen in AD. Many laboratory, animal and epidemiological studies have pointed towards a possible beneficial role for vitamin E in the prevention and treatment of AD. However, to date very limited evidence exists in humans to support the routine use of vitamin E. Further, in recent years evidence has come to light implicating vitamin E with potentially serious side effects and even increased mortality. In this review three studies were identified and these demonstrated no or limited benefit for vitamin E in MCI and AD. Therefore, vitamin E should not be used in the treatment of MCI or AD. More trials are still needed but these should include different forms of vitamin E.

This record should be cited as: 
Farina N, Isaac MGEKN, Clark AR, Rusted J, Tabet N. Vitamin E for Alzheimer's dementia and mild cognitive impairment. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD002854. DOI: 10.1002/14651858.CD002854.pub3
Assessed as up to date: 
25 June 2012