Cochrane Summaries

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Dihydrocodeine in a single dose in the treatment of acute postoperative pain

Moore RA, Edwards J, Derry S, McQuay HJ
Published Online: 
16 March 2011

This review assessed the efficacy of single-dose dihydrocodeine in adults with moderate/severe postoperative pain using information from randomised placebo controlled trials. There was a lack of data that could be included in the analyses; all assessed the oral form of the drug and none assessed dihydrocodeine 60 mg. The results were not robust. The implication was that single-dose oral dihydrocodeine 30 mg was more effective than placebo, but was inferior to ibuprofen 400 mg. Dizziness, drowsiness and confusion were commonly reported.