Leukotriene receptor antagonists for non-cystic fibrosis bronchiectasis

Corless JA, Warburton CJ

Published Online:

July 6, 2011

Leukotriene receptor antagonists are a new class of drug which may have an anti-inflammatory action in some patients with asthma. In theory they may also be of benefit in bronchiectasis, but no randomised controlled trials have yet been reported so it is not possible to make a recommendation about their use in this condition.

Abstract (click to read)

Background:

Leukotriene receptor antagonists are a new class of drug that were initially identified for use in asthma. As they have an effect on neutrophil mediated inflammation, they may be of benefit in bronchiectasis.

Objectives:

To determine whether leukotriene receptor antagonists have any additive benefit over and above conventional treatment for bronchiectasis (usually consisting of antibiotics and postural drainage).

Search strategy:

The Cochrane Airways Group Specialised Regsiter of trials and CENTRAL were searched up to May 2011.

Selection criteria:

Only randomised, controlled trials were considered

Data collection and analysis:

The results of searches were analysed by both authors

Main results:

No randomised, controlled trials were identified. The latest search was in May 2011.

Authors' conclusions:

Further research is required to establish any benefit from the use of leukotriene antagonists in bronchiectasis.

This record should be cited as:

Corless JA, Warburton CJ. Leukotriene receptor antagonists for non-cystic fibrosis bronchiectasis. Cochrane Database of Systematic Reviews 2000, Issue 4. Art. No.: CD002174. DOI: 10.1002/14651858.CD002174

Assessed as up to date:

May 5, 2011

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Primary Review Group:

Airways Group

Health topics:

Lungs & airways > Bronchiectasis

Cochrane Summaries^beta

Independent high-quality evidence for health care decision making

Leukotriene receptor antagonists for non-cystic fibrosis bronchiectasis

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