Intravenous antibiotics given at home for people with cystic fibrosis

Cystic fibrosis (CF) is a serious genetic disease linked with recurrent lung infections. As a result of these, the person's lung disease becomes progressively worse. Lung infections are often treated with intravenous (IV) antibiotics in hospital for a number of weeks. This is costly and disrupts the life of people with CF. Treatment can be received at home if individuals and their carers are given enough training and support. We looked for randomised controlled trials which compared IV antibiotic treatment in hospital with treatment at home. We found one study of 17 people. There were no differences for clinical outcomes, adverse events, or complications linked to IV treatment. People at home were more tired and found the treatment more difficult to master. This may be due to them being more active and needing more support. Home therapy was cheaper for families and the hospital. There were no details about indirect costs. We conclude that treatment at home does not harm people in the short term and does reduce social disruption. However, the decision in favour of this option must be made on an individual basis. The evidence is very limited and more research is strongly needed to recommend its use.