Not enough evidence on routine antibiotics to prevent infection for women seeking care after incomplete abortion, but a single dose may be more suitable

May W, Gülmezoglu AM, Ba-Thike K

Published Online:

July 16, 2008

Incomplete abortions cause many complications and the deaths of tens of thousands of women each year. Women who seek health care after an incomplete abortion usually come for problems from bleeding too much or infection. Antibiotics are generally given when there are signs of infection. The review of trials showed difficulties for women in continuing to take antibiotics and returning for care, so single dose antibiotics may be more suitable in these circumstances. The trials did not provide enough evidence to show the effects of routine antibiotics for women after incomplete abortion.

Abstract (click to read)

Background:

Unsafe abortions result not only in costs for acute care but may also be responsible for longer-term complications such as pelvic inflammatory disease, damage to reproductive organs, and secondary infertility. If effective, antibiotic prophylaxis at the time of the procedure can potentially prevent these adverse consequences.

Objectives:

The value of routine antibiotics before surgical evacuation of the uterus in women with incomplete abortion is controversial. In some health centres antibiotic prophylaxis is advised; in others antibiotics are only prescribed when there are signs of infection. The objective of this review is to evaluate the effectiveness of routine antibiotic prophylaxis to women with incomplete abortion.

Search strategy:

We searched the Cochrane Controlled Trials Register, Pubmed/MEDLINE, EMBASE and Popline. Date of last search: January 2007.

Selection criteria:

Randomised trials comparing a policy of routine antibiotic prophylaxis with no routine prophylaxis were eligible for inclusion.

Data collection and analysis:

Data extraction was conducted by two reviewers independently. Trial quality was assessed.

Main results:

One study involving 140 women was included. A second well-conducted trial was excluded because of high losses to follow-up. No differences were detected in postabortal infection rates with routine prophylaxis or control. However, compliance with antibiotic treatment was also low.

Authors' conclusions:

There is not enough evidence to evaluate a policy of routine antibiotic prophylaxis to women with incomplete abortion.

This record should be cited as:

May W, Gülmezoglu AM, Ba-Thike K. Antibiotics for incomplete abortion. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD001779. DOI: 10.1002/14651858.CD001779.pub2

Assessed as up to date:

July 2, 2007

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Primary Review Group:

Fertility Regulation Group

Health topics:

Gynaecology > Therapeutic abortion > General

Cochrane Summaries^beta

Independent high-quality evidence for health care decision making

Not enough evidence on routine antibiotics to prevent infection for women seeking care after incomplete abortion, but a single dose may be more suitable

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