Antioxidant vitamins and mineral supplements to slow down the progression of age-related macular degeneration

Age-related macular degeneration (AMD) is a condition affecting the central area of the retina (back of the eye). The retina can deteriorate with age and some people get lesions that can lead to loss of central vision. It has been suggested that progression of the disease may be slowed down in people who eat a diet rich in antioxidant vitamins (carotenoids, vitamins C and E) or minerals (selenium and zinc). The author identified nine randomised controlled trials; four trials based in the USA, four in Australia, Austria, Switzerland and the UK and one in China. The review of trials found that supplementation with antioxidants and zinc may be of modest benefit in people with AMD. Long-term harm from these supplements cannot be ruled out. Large well-conducted trials in a range of populations and with different nutritional status are required.