Interventions for trichomoniasis in pregnancy

Gülmezoglu AM, Azhar M

Published Online:

May 11, 2011

Metronidazole is effective against a trichomoniasis infection during pregnancy, but may increase the risk of preterm and low birthweight babies.

Trichomoniasis is a very common sexually transmitted infection. Symptoms include vaginal itching and discharge. It is not clear if pregnant women with trichomoniasis are more likely to give birth preterm, or have other pregnancy complications. The review of two trials, involving 842 women, found that the drug metronidazole is effective against trichomoniasis when taken by women and their partners during pregnancy, but it may harm the baby due to early birth. One of the trials was stopped early because women taking metronidazole were more likely to give birth preterm and have low birthweight babies. Further research into trichomoniasis treatments for pregnant women is needed.

Abstract (click to read)

Background:

Vaginitis due to Trichomonas vaginalis is one of the most common of sexually transmitted diseases. Trichomoniasis affects women during pregnancy as well but it is not clearly established whether it causes preterm birth and other pregnancy complications.

Objectives:

The objective of this review was to assess the effects of various treatments for trichomoniasis during pregnancy.

Search strategy:

We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (14 January 2011).

Selection criteria:

Randomized trials comparing anti-trichomonas agents during pregnancy. Trials including symptomatic or asymptomatic women with trichomoniasis were eligible.

Data collection and analysis:

Two review authors assessed eligibility and trial quality.

Main results:

We included two trials with 842 pregnant women. In both trials around 90% of women were cleared of trichomonas in the vagina after treatment. In the US trial, women with asymptomatic trichomoniasis between 16 and 23 weeks were treated with metronidazole on two occasions at least two weeks apart. The trial was stopped before reaching its target recruitment because metronidazole was not effective in reducing preterm birth and there was a likelihood of harm (risk ratio 1.78; 95% confidence interval 1.19 to 2.66). The South African trial recruited women later in pregnancy and did not have the design and power to address adverse clinical outcomes. We excluded two recent studies, identified for the current update, because they did not address the primary question.

Authors' conclusions:

Metronidazole, given as a single dose, is likely to provide parasitological cure for trichomoniasis, but it is not known whether this treatment will have any effect on pregnancy outcomes. The cure rate could probably be higher if more partners used the treatment.

This record should be cited as:

Gülmezoglu AM, Azhar M. Interventions for trichomoniasis in pregnancy. Cochrane Database of Systematic Reviews 2011, Issue 5. Art. No.: CD000220. DOI: 10.1002/14651858.CD000220.pub2

Assessed as up to date:

March 8, 2011

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Primary Review Group:

Pregnancy and Childbirth Group

Health topics:

Gynaecology > Sexually transmitted disease > Trichomoniasis

Infectious disease > Sexually transmitted disease > Trichomoniasis

Pregnancy & childbirth > Infection during pregnancy > Sexually transmitted diseases

Cochrane Summaries^beta

Independent high-quality evidence for health care decision making

Interventions for trichomoniasis in pregnancy

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