Combined inhaled anticholinergics and beta2-agonists for initial treatment of acute asthma in children

Plotnick L, Ducharme F

Published Online:

October 8, 2008

In an asthma attack, the airways (passages to the lungs) narrow from muscle spasms. Bronchodilators (reliever inhalers) relax the muscles in the airways, opening the airways so breathing is easier. Anti-cholinergic drugs can also affect these muscles, and so are sometimes used as well as bronchodilators when children have severe asthma attacks. The review of trials found using both drugs together improves outcomes for children with severe asthma attacks, although there is not enough evidence about effects for children with mild or moderate attacks. More research on possible adverse effects of the extra drug is needed, although it seems safe.

Abstract (click to read)

Background:

Several randomized controlled trials have examined, with conflicting results, the efficacy of the addition of anticholinergics to beta2 agonists in acute pediatric asthma. The pooling for a larger number of randomized controlled trials may provide not only greater power for detecting group differences and also provide better insight into the influence of patients' characteristics and treatment modalities on efficacy.

Objectives:

The aims of this study were to estimate the therapeutic and adverse effects attributable to the addition of inhaled anticholinergics to beta2 agonists in acute pediatric asthma.

Search strategy:

We searched MEDLINE (1966 to April 2000), EMBASE (1980 to April 2000), CINAHL (1982 to April 2000) and reference lists of studies. We also contacted drug manufacturers and trialists.

Selection criteria:

Randomised trials comparing the combination of inhaled anticholinergics and beta2 agonists with beta2 agonists alone in children aged 18 months to 17 years with acute asthma.

Data collection and analysis:

Assessments of trial quality and data extraction were done by two reviewers independently.

Main results:

Of the 40 identified trials, 13 were relevant and eight of these were of high quality. The addition of a single dose of anticholinergic to beta2 agonists did not reduce hospital admission [RR=0.93 (95% CI: 0.65, 1.32)]. However, significant group differences in lung function supporting the combination of anticholinergics and beta2-agonists were observed 60 minutes [SMD=0.57 (95% CI:0.21, 0.93)] and 120 minutes [SMD=0.53 (95% CI: 0.17, 0.90)] after the dose of anticholinergic. In contrast, the addition of multiple doses of anticholinergics to beta2 agonists reduced the risk of hospital admission by 25% [RR=0.75 (95% CI: 0.62,0.89)] in children with predominantly moderate and severe exacerbations. Twelve (95% CI: 8, 32) children would need to be treated to avoid one admission. When restricting this strategy to children with severe exacerbations, seven (95% CI: 5, 20) children need to be treated to avoid an admission. At 60 minutes after the last anticholinergic inhalation, a weighted mean group difference of 9.68 in change in % predicted FEV1 [95% CI:5.70, 13.68] favoured anticholinergic use. In the two studies where anticholinergics were systematically added to every beta2 agonist inhalation, irrespective of asthma severity, no group differences were observed for the few available outcomes. There was no increase in the amount of nausea, vomiting or tremor in patients treated with anticholinergics.

Authors' conclusions:

A single dose of an anticholinergic agent is not effective for the treatment of mild and moderate exacerbations and is insufficient for the treatment of severe exacerbations. Adding multiple doses of anticholinergics to beta2 agonists appears safe, improves lung function and would avoid hospital admission in 1 of 12 such treated patients. Although multiple doses should be preferred to single doses of anticholinergics, the available evidence only supports their use in school-aged children with severe asthma exacerbation. There is no conclusive evidence for using multiple doses of anticholinergics in children with mild or moderate exacerbations.

This record should be cited as:

Plotnick L, Ducharme F. Combined inhaled anticholinergics and beta2-agonists for initial treatment of acute asthma in children. Cochrane Database of Systematic Reviews 1997, Issue 3. Art. No.: CD000060. DOI: 10.1002/14651858.CD000060

Assessed as up to date:

April 25, 2000

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Primary Review Group:

Airways Group

Asthma topics:

Treating with Medications > Asthma Attacks > Anticholinergics

Treating with Medications > Asthma Attacks > Beta agonists

Health topics:

Lungs & airways > Asthma (acute) > Bronchodilators

Cochrane Summaries^beta

Independent high-quality evidence for health care decision making

Combined inhaled anticholinergics and beta2-agonists for initial treatment of acute asthma in children

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