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Does clonidine help smokers to quit

Gourlay SG, Stead LF, Benowitz N
Published Online: 
8 October 2008

Clonidine is a drug used to lower blood pressure, but it may also reduce drug and alcohol withdrawal symptoms. The review of trials found that clonidine can lead to a small increase in the number of people likely to quit smoking. However, the quality of the trials was poor, which makes the evidence less reliable. Adverse effects of clonidine included a dry mouth and sedation. Clonidine may not be the best option for people trying to quit smoking, but it might be useful for people who are not helped by nicotine replacement therapy or antidepressants.

This record should be cited as: 
Gourlay SG, Stead LF, Benowitz N. Clonidine for smoking cessation. Cochrane Database of Systematic Reviews 2004, Issue 3. Art. No.: CD000058. DOI: 10.1002/14651858.CD000058.pub2
Assessed as up to date: 
16 June 2008